Detalhe da pesquisa
1.
When Good Intentions Go Awry: Modification of a Recombinant Monoclonal Antibody in Chemically Defined Cell Culture by Xylosone, an Oxidative Product of Ascorbic Acid.
Anal Chem
; 87(15): 7529-34, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26151084
2.
Discovery of a chemical modification by citric acid in a recombinant monoclonal antibody.
Anal Chem
; 86(18): 8932-6, 2014 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25136741
3.
Arginine modifications by methylglyoxal: discovery in a recombinant monoclonal antibody and contribution to acidic species.
Anal Chem
; 85(23): 11401-9, 2013 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24168114
4.
Effect of the light chain C-terminal serine residue on disulfide bond susceptibility of human immunoglobulin G1λ.
Anal Biochem
; 408(2): 277-83, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869344
5.
Cytokine traps: multi-component, high-affinity blockers of cytokine action.
Nat Med
; 9(1): 47-52, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12483208
6.
Insights into the Conformation and Self-Association of a Concentrated Monoclonal Antibody using Isothermal Chemical Denaturation and Nuclear Magnetic Resonance.
J Pharm Sci
; 110(12): 3819-3828, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34506864
7.
Ranking the susceptibility of disulfide bonds in human IgG1 antibodies by reduction, differential alkylation, and LC-MS analysis.
Anal Chem
; 82(12): 5219-26, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20491447
8.
Elevated cleavage of human immunoglobulin gamma molecules containing a lambda light chain mediated by iron and histidine.
Anal Biochem
; 389(2): 107-17, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19318085
9.
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment.
J Clin Invest
; 113(7): 1040-50, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15057311
10.
Higher order structures of Adalimumab, Infliximab and their complexes with TNFα revealed by electron microscopy.
Protein Sci
; 26(12): 2392-2398, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28940886
11.
Monoclonal antibody classification based on epitope-binding using differential antigen disruption.
J Immunol Methods
; 314(1-2): 9-20, 2006 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-16831443
12.
Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule.
MAbs
; 5(3): 432-44, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23608772
13.
The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen.
MAbs
; 5(3): 364-72, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23572180
14.
A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation.
MAbs
; 4(4): 521-31, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22647389
15.
Increased serum clearance of oligomannose species present on a human IgG1 molecule.
MAbs
; 4(4): 509-20, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22669558
16.
Comparability analysis of protein therapeutics by bottom-up LC-MS with stable isotope-tagged reference standards.
MAbs
; 3(4): 387-95, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21654206
17.
Mass spectrometry analysis of in vitro nitration of a recombinant human IgG1 monoclonal antibody.
Rapid Commun Mass Spectrom
; 22(1): 1-10, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18041795
18.
Binding of discoidin domain receptor 2 to collagen I: an atomic force microscopy investigation.
Biochemistry
; 41(37): 11091-8, 2002 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12220173
19.
VEGF-Trap: a VEGF blocker with potent antitumor effects.
Proc Natl Acad Sci U S A
; 99(17): 11393-8, 2002 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12177445
20.
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.
Nat Struct Biol
; 10(1): 38-44, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12469114