Detalhe da pesquisa
1.
Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 20(15): 4614-9, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20584604
2.
GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796.
Antimicrob Agents Chemother
; 53(5): 2129-32, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19273674
3.
Modulation of alpha interferon anti-hepatitis C virus activity by ISG15.
J Gen Virol
; 90(Pt 12): 2929-2939, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19656964
4.
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).
Bioorg Med Chem Lett
; 19(15): 4250-4, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19505826
5.
3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase.
Bioorg Med Chem Lett
; 19(2): 410-4, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19070486
6.
Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
Bioorg Med Chem Lett
; 19(13): 3637-41, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19447623
7.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
Bioorg Med Chem Lett
; 19(19): 5652-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19709881
8.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.
Bioorg Med Chem Lett
; 19(13): 3642-6, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19457662
9.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Bioorg Med Chem Lett
; 19(19): 5648-51, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700319
10.
The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors.
Antimicrob Agents Chemother
; 52(5): 1604-12, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18285474
11.
Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients.
J Antimicrob Chemother
; 61(6): 1205-16, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18343801
12.
First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
J Med Chem
; 50(22): 5463-70, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17914786
13.
Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
J Med Chem
; 50(8): 1840-9, 2007 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17367121
14.
In vitro selection of resistance to sofosbuvir in HCV replicons of genotype-1 to -6.
Antivir Ther
; 22(7): 587-597, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28248189
15.
Pseudomonas aeruginosa-specific IgG1 and IgG2 subclasses in enhancement of pulmonary clearance following passive immunisation in the rat.
FEMS Immunol Med Microbiol
; 39(1): 37-44, 2003 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-14556994
16.
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1914-31, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24195700
17.
Development and characterization of a replicon-based phenotypic assay for assessing HCV NS4B from clinical isolates.
Antiviral Res
; 100(2): 328-36, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24013002
18.
Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.
J Med Chem
; 56(20): 8163-82, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24069953
19.
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
J Med Chem
; 52(1): 219-23, 2009 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19055482
20.
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
J Med Chem
; 52(9): 2971-8, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19341305