Detalhe da pesquisa
1.
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Cell
; 186(5): 1013-1025.e24, 2023 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36827973
2.
Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res
; 51(21): 11732-11747, 2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37870477
3.
Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule.
J Biol Chem
; 290(2): 762-74, 2015 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25391653
4.
Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2.
Sci Rep
; 14(1): 2038, 2024 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38263191
5.
The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1.
Bioorg Med Chem Lett
; 23(12): 3620-6, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23648182
6.
The PX-BAR membrane-remodeling unit of sorting nexin 9.
EMBO J
; 26(22): 4788-800, 2007 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17948057
7.
Fast Mek1 Hit Identification with TRIC Technology Correlates Well with Other Biophysical Methods.
SLAS Discov
; 26(8): 1014-1019, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34238039
8.
The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.
Structure
; 16(9): 1313-23, 2008 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18786395
9.
Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity.
Commun Biol
; 3(1): 427, 2020 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32759959
10.
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
J Med Chem
; 63(2): 512-528, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31721572
11.
Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor.
ChemMedChem
; 14(11): 1115-1127, 2019 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30925009
12.
[Developability assessment with case studies highlighting the decision taking]. / Exemples d'études de développabilité apportant un éclairage à la prise de décision.
Med Sci (Paris)
; 35(12): 1171-1174, 2019 Dec.
Artigo
em Francês
| MEDLINE | ID: mdl-31903933
13.
Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab.
Cells
; 8(12)2019 11 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31779273
14.
A combinatorial approach to crystallization of PX-BAR unit of the human Sorting Nexin 9.
J Struct Biol
; 162(2): 356-60, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18065239
15.
Sec2 is a highly efficient exchange factor for the Rab protein Sec4.
J Mol Biol
; 365(5): 1359-67, 2007 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17134721
16.
Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases.
Anal Biochem
; 381(2): 258-66, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18638444
17.
Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations.
J Chem Theory Comput
; 14(7): 3859-3869, 2018 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29768913
18.
Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 63(Pt 10): 878-81, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17909294
19.
Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 62(Pt 2): 113-6, 2006 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16511278
20.
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases.
Structure
; 10(4): 569-79, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11937061