Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.

Talapatra, Sandeep K; Rath, Oliver; Clayton, Eddie; Tomasi, Sophie; Kozielski, Frank.

J Nat Prod ; 79(6): 1576-85, 2016 06 24.

Artigo em Inglês | MEDLINE | ID: mdl-27300079

2.

Structural insights into a unique inhibitor binding pocket in kinesin spindle protein.

Ulaganathan, Venkatasubramanian; Talapatra, Sandeep K; Rath, Oliver; Pannifer, Andrew; Hackney, David D; Kozielski, Frank.

J Am Chem Soc ; 135(6): 2263-72, 2013 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-23305346

3.

Regulation of human myoblast differentiation by PEBP4.

Garcia, Reynaldo; Grindlay, Joan; Rath, Oliver; Fee, Frances; Kolch, Walter.

EMBO Rep ; 10(3): 278-84, 2009 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-19197339

4.

The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.

Rath, Oliver; Park, Sungdae; Tang, Hui-hui; Banfield, Mark J; Brady, R Leo; Lee, Yie Chia; Dignam, John D; Sedivy, John M; Kolch, Walter; Yeung, Kam C.

Cell Signal ; 20(5): 935-41, 2008 May.

Artigo em Inglês | MEDLINE | ID: mdl-18294816

5.

c-Myc is required for transformation of FDC-P1 cells by EGFRvIII.

Rath, Oliver; Himmler, Adi; Baum, Anke; Sommergruber, Wolfgang; Beug, Hartmut; Metz, Thomas.

FEBS Lett ; 581(13): 2549-56, 2007 May 29.

Artigo em Inglês | MEDLINE | ID: mdl-17499721

6.

Development of Novel Patient-Derived Preclinical Models from Malignant Effusions in Patients with Tyrosine Kinase Inhibitor-Resistant Clear Cell Renal Cell Carcinoma.

Jang, Jiryeon; Rath, Oliver; Schueler, Julia; Sung, Hyun Hwan; Jeon, Hwang Gyun; Jeong, Byong Chang; Seo, Seong Il; Jeon, Seong Soo; Lee, Hyun Moo; Choi, Han-Yong; Kwon, Ghee-Young; Park, Woong Yang; Lee, Jeeyun; Park, Se Hoon.

Transl Oncol ; 10(3): 304-310, 2017 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-28325666

7.

Regulation of RKIP binding to the N-region of the Raf-1 kinase.

Park, Sungdae; Rath, Oliver; Beach, Sandy; Xiang, Xiaoqin; Kelly, Sharon M; Luo, Zhijun; Kolch, Walter; Yeung, Kam C.

FEBS Lett ; 580(27): 6405-12, 2006 Nov 27.

Artigo em Inglês | MEDLINE | ID: mdl-17097642

8.

BEZ235 (PIK3/mTOR inhibitor) Overcomes Pazopanib Resistance in Patient-Derived Refractory Soft Tissue Sarcoma Cells.

Kim, Hee Kyung; Kim, Sun Young; Lee, Su Jin; Kang, Mihyeon; Kim, Seung Tae; Jang, Jiryeon; Rath, Oliver; Schueler, Julia; Lee, Dong Woo; Park, Woong Yang; Kim, Sung Joo; Park, Se Hoon; Lee, Jeeyun.

Transl Oncol ; 9(3): 197-202, 2016 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-27267837

9.

Relocation of AuroraâB and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.

Tcherniuk, Sergey; Skoufias, Dimitrios A; Labriere, Christophe; Rath, Oliver; Gueritte, Françoise; Guillou, Catherine; Kozielski, Frank.

Angew Chem Int Ed Engl ; 49(44): 8228-31, 2010 Oct 25.

Artigo em Inglês | MEDLINE | ID: mdl-20857469

10.

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.

Mardilovich, Katerina; Baugh, Mark; Crighton, Diane; Kowalczyk, Dominika; Gabrielsen, Mads; Munro, June; Croft, Daniel R; Lourenco, Filipe; James, Daniel; Kalna, Gabriella; McGarry, Lynn; Rath, Oliver; Shanks, Emma; Garnett, Mathew J; McDermott, Ultan; Brookfield, Joanna; Charles, Mark; Hammonds, Tim; Olson, Michael F.

Oncotarget ; 6(36): 38469-86, 2015 Nov 17.

Artigo em Inglês | MEDLINE | ID: mdl-26540348

11.

Patient-derived cell models as preclinical tools for genome-directed targeted therapy.

Lee, Ji Yun; Kim, Sun Young; Park, Charny; Kim, Nayoung K D; Jang, Jiryeon; Park, Kyunghee; Yi, Jun Ho; Hong, Mineui; Ahn, Taejin; Rath, Oliver; Schueler, Julia; Kim, Seung Tae; Do, In-Gu; Lee, Sujin; Park, Se Hoon; Ji, Yong Ick; Kim, Dukwhan; Park, Joon Oh; Park, Young Suk; Kang, Won Ki; Kim, Kyoung-Mee; Park, Woong-Yang; Lim, Ho Yeong; Lee, Jeeyun.

Oncotarget ; 6(28): 25619-30, 2015 Sep 22.

Artigo em Inglês | MEDLINE | ID: mdl-26296973

12.

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

Good, James A D; Wang, Fang; Rath, Oliver; Kaan, Hung Yi Kristal; Talapatra, Sandeep K; Podgórski, Dawid; MacKay, Simon P; Kozielski, Frank.

J Med Chem ; 56(5): 1878-93, 2013 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-23394180

13.

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity.

von Thun, Anne; Preisinger, Christian; Rath, Oliver; Schwarz, Juliane P; Ward, Chris; Monsefi, Naser; Rodríguez, Javier; Garcia-Munoz, Amaya; Birtwistle, Marc; Bienvenut, Willy; Anderson, Kurt I; Kolch, Walter; von Kriegsheim, Alex.

Mol Cell Biol ; 33(22): 4526-37, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-24043311

14.

Kinesins and cancer.

Rath, Oliver; Kozielski, Frank.

Nat Rev Cancer ; 12(8): 527-39, 2012 Jul 24.

Artigo em Inglês | MEDLINE | ID: mdl-22825217

15.

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Wang, Fang; Good, James A D; Rath, Oliver; Kaan, Hung Yi Kristal; Sutcliffe, Oliver B; Mackay, Simon P; Kozielski, Frank.

J Med Chem ; 55(4): 1511-25, 2012 Feb 23.

Artigo em Inglês | MEDLINE | ID: mdl-22248262

16.

Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.

Abualhasan, Murad N; Good, James A D; Wittayanarakul, Kitiyaporn; Anthony, Nahoum G; Berretta, Giacomo; Rath, Oliver; Kozielski, Frank; Sutcliffe, Oliver B; Mackay, Simon P.

Eur J Med Chem ; 54: 483-98, 2012 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-22749640

17.

RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility.

al-Mulla, Fahd; Bitar, Milad S; Taqi, Zainab; Rath, Oliver; Kolch, Walter.

Mol Biosyst ; 7(3): 928-41, 2011 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-21180766

18.

Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3ß.

Al-Mulla, Fahd; Bitar, Milad S; Al-Maghrebi, May; Behbehani, Abdulla I; Al-Ali, Waleed; Rath, Oliver; Doyle, Brendan; Tan, Kit Yee; Pitt, Andrew; Kolch, Walter.

Cancer Res ; 71(4): 1334-43, 2011 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-21303975

19.

Investigating dynamics of inhibitory and feedback loops in ERK signalling using power-law models.

Vera, Julio; Rath, Oliver; Balsa-Canto, Eva; Banga, Julio R; Kolch, Walter; Wolkenhauer, Olaf.

Mol Biosyst ; 6(11): 2174-91, 2010 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20717620

20.

Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition.

Shin, Sung-Young; Rath, Oliver; Zebisch, Armin; Choo, Sang-Mok; Kolch, Walter; Cho, Kwang-Hyun.

Cancer Res ; 70(17): 6715-24, 2010 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-20736375

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