Detalhe da pesquisa
1.
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
Bioorg Med Chem Lett
; 29(16): 2090-2093, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311734
2.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett
; 29(12): 1522-1531, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30981576
3.
The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD.
Bioorg Med Chem Lett
; 23(23): 6248-53, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24144851
4.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.
Bioorg Med Chem Lett
; 22(24): 7376-80, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23131342
5.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem
; 64(16): 11841-11856, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34251202
6.
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity.
Bioorg Med Chem Lett
; 18(4): 1312-7, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18226897
7.
Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.
Sci Transl Med
; 10(468)2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463918
8.
A solid-phase route to N-cyanoamides.
Org Lett
; 4(4): 597-8, 2002 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-11843600
9.
Muscarinic antagonist-beta-adrenergic agonist dual pharmacology molecules as bronchodilators: a patent review.
Expert Opin Ther Pat
; 19(1): 1-12, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19441894
10.
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators.
Bioorg Med Chem Lett
; 17(17): 4901-5, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17587578
11.
2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists.
Bioorg Med Chem Lett
; 17(20): 5704-8, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17822897
12.
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.
Bioorg Med Chem Lett
; 15(23): 5335-9, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16202581
13.
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Bioorg Med Chem Lett
; 15(3): 751-4, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664851