Two Consecutive Invasive Surgeries Utilizing Zymogen Protein C (ZPC) That Enhanced Patient Safety and Reduced Costs.

This case report describes a major surgical procedure for a protein C-deficient, hypercoagulable patient who underwent two back-to-back invasive surgeries, hip replacement, and spinal stenosis correction. The patient, an 84-year-old male with a history of deep vein thromboses (DVT) and pulmonary emboli (PE), was treated pre-, peri-, and postoperatively with zymogen protein C (ZPC-Baxter, International) and recovered without clotting or increased bleeding. During the procedure, the patient was not administered any other anticoagulants. There have now been several case reports on different patients with unrelated teams in various locations worldwide using zymogen protein C during surgical procedures. Thus, this procedure is becoming a viable choice for patients with a high probability of clotting during and after invasive surgery. This case focuses on accomplishing safer surgery and reducing costs, by using less ZPC while accomplishing two surgeries in one procedure. As a result, this procedure might be useful for many medical situations where acquired protein C deficiency could be a problem (e.g., sepsis, pregnancy, etc.). This approach may have greater application to medical conditions other than protein C deficiency, where clotting and inflammation can become issues.

A review of comorbidities and spinal surgery.

As the population ages, greater numbers of elderly patients will be considered for spinal surgery for spinal stenosis and complex primary and revision reconstructions. The age-related medical comorbidities impact not only on the decision to undertake a procedure but also impact the magnitude of the procedure. The surgeon must understand aging and medical comorbidities to facilitate preoperative decision-making and postoperative care. A review of the more common age-related pathophysiologic changes to the cardiovascular, pulmonary, and central nervous systems is undertaken. General recommendations for perioperative treatment are made relative to published series regarding the impact of age and medical comorbidities on short- and long-term outcomes.