Detalhe da pesquisa
1.
Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy.
Am J Hum Genet
; 98(4): 735-43, 2016 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27058446
2.
Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation.
Biochemistry
; 55(51): 7073-7085, 2016 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27958713
3.
Design and optimization of selective azaindole amide M1 positive allosteric modulators.
Bioorg Med Chem Lett
; 26(2): 650-655, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26631313
4.
Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder.
Neurobiol Dis
; 77: 220-7, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25796564
5.
Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling.
Transl Psychiatry
; 11(1): 136, 2021 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33608496
6.
Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder.
Transl Psychiatry
; 9(1): 151, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31123247
7.
Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.
J Med Chem
; 59(13): 6313-28, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27275946
8.
STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder.
PLoS One
; 10(3): e0121744, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25786133
9.
Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain.
Cell Signal
; 26(2): 383-97, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24184653