1.
Pediatr Blood Cancer
; 65(8): e27218, 2018 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29722478
RESUMO
Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare cause of bone marrow failure in children. We report two children who presented with pancytopenia, and were diagnosed with PNH with severe aplastic anemia. Both children underwent upfront, successful hematopoietic stem cell transplantation with reduced-intensity conditioning. One patient had a syngeneic donor, and one patient had a 10/10 matched unrelated donor. Neither patient developed graft versus host disease, infections, or recurrent PNH. Reduced-intensity conditioning hematopoietic stem cell transplantation is a reasonable therapy for PNH with marrow failure in children.
Assuntos
Anemia Aplástica/terapia , Transplante de Células-Tronco Hematopoéticas , Hemoglobinúria Paroxística/terapia , Condicionamento Pré-Transplante , Adolescente , Humanos , Masculino
2.
Acad Pediatr
; 23(2): 497-499, 2023 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35623549