RESUMO
Angelica polymorpha Maxim. is a plant of the Angelica genus (Umbelliferae). The root and stem of this plant is a folk medicine known to have the actions of relieving rheumatism and cold and subsiding swelling and pains. To investigate the chemical constituents in the root of A. polymorpha Maxim., seven compounds were isolated from an 80% ethanol extract by column chromatography. Their structures were elucidated according to the spectroscopic analysis. Compound 1 is a new sesquiterpene, named as bisabolactone. Its absolute configuration was determined by 1D NOESY and CD analysis. The others were identified as 5-hydroxymethylfurfural (2), hycandinic acid ester 1 (3), ferulic acid (4), isooxypeucedanin (5), noreugenin (6) and cimifugin (7). Compound 2 and 3 were isolated from this genus for the first time and compound 4 was isolated from this plant for the first time.
Assuntos
Angelica/química , Plantas Medicinais/química , Sesquiterpenos/isolamento & purificação , Cromonas/química , Cromonas/isolamento & purificação , Ácidos Cumáricos/química , Ácidos Cumáricos/isolamento & purificação , Cumarínicos/química , Cumarínicos/isolamento & purificação , Furaldeído/análogos & derivados , Furaldeído/química , Furaldeído/isolamento & purificação , Estrutura Molecular , Raízes de Plantas/química , Ácido Quínico/análogos & derivados , Ácido Quínico/química , Ácido Quínico/isolamento & purificação , Sesquiterpenos/químicaRESUMO
To investigate the chemical constituents of hemostatic extract of Pyrola calliantha H. Andres, the extract was subjected to chromatographic separation and purification. Along with some known compounds, a new naphthaquinone derivative was isolated and identified as 2-(1, 4-dihydro-2, 6-dimethyl-1, 4-dioxo-3-naphthalenyl)-3, 4, 5-trihydroxylbenzoic acid by physicochemical and spectroscopic analysis.
Assuntos
Naftoquinonas/isolamento & purificação , Plantas Medicinais/química , Pyrola/química , Estrutura Molecular , Naftoquinonas/químicaRESUMO
OBJECTIVE: To establish a RP-HPLC method for determination of glycosides in Traditional Chinese Medicine Liu-wei Di-huang. METHOD: The samples were analyzed on an ODS column at 30 degrees C, with mobile phase of methanol/water (33:67) at flow rate 1.0 mL.min and detection at wavelength of 236 nm. RESULT: Three major components reached base-line separation and were identified to be mononiside, loganin, paeoniflorin. Respectively for the three components, linear correlations were found between peak areas and concentrations in the ranges of 7.4-60, 7.7-62 mg.L-1 and 8.5-68 mg.L-1, and the recoveries were 98.8%, 98.3%, 99.6%. CONCLUSION: The established method is proved to be suitable for simultaneous quantification of three major glycosidic components in Liuwei Dihuang decoction and can be used for evaluation of the quality of Liuwei Dihuang preparations.
Assuntos
Benzoatos/análise , Hidrocarbonetos Aromáticos com Pontes/análise , Medicamentos de Ervas Chinesas/análise , Medicamentos de Ervas Chinesas/química , Glucosídeos/análise , Iridoides/análise , Plantas Medicinais/química , Cromatografia Líquida de Alta Pressão/métodos , Cornus/química , Dioscorea/química , Combinação de Medicamentos , Monoterpenos , Controle de Qualidade , Rehmannia/químicaRESUMO
A simple, four-step synthesis of D-lividosamine starting from N-acetyl-D-glucosamine via a furanosyl oxazoline intermediate is described.