Detalhe da pesquisa
1.
Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2.
J Am Chem Soc
; 144(46): 21035-21045, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36356199
2.
Protein-Ribofuranosyl Interactions Activate Orotidine 5'-Monophosphate Decarboxylase for Catalysis.
Biochemistry
; 60(45): 3362-3373, 2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726391
3.
The Organization of Active Site Side Chains of Glycerol-3-phosphate Dehydrogenase Promotes Efficient Enzyme Catalysis and Rescue of Variant Enzymes.
Biochemistry
; 59(16): 1582-1591, 2020 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32250105
4.
Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies.
Biochemistry
; 58(8): 1061-1073, 2019 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30640445
5.
Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis.
Acc Chem Res
; 51(4): 960-969, 2018 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29595949
6.
Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer.
Biochemistry
; 57(23): 3227-3236, 2018 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29337541
7.
Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase.
Biochemistry
; 57(29): 4338-4348, 2018 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29927590
8.
Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5'-Monophosphate Decarboxylase for Catalysis.
J Am Chem Soc
; 140(50): 17580-17590, 2018 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30475611
9.
Enzyme Architecture: Erection of Active Orotidine 5'-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes.
J Am Chem Soc
; 139(45): 16048-16051, 2017 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29058891
10.
A reevaluation of the origin of the rate acceleration for enzyme-catalyzed hydride transfer.
Org Biomol Chem
; 15(42): 8856-8866, 2017 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28956050
11.
Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer.
Biochemistry
; 55(10): 1429-32, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26926520
12.
Enzyme Architecture: Self-Assembly of Enzyme and Substrate Pieces of Glycerol-3-Phosphate Dehydrogenase into a Robust Catalyst of Hydride Transfer.
J Am Chem Soc
; 138(46): 15251-15259, 2016 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27792325
13.
Structure-Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase.
J Am Chem Soc
; 138(44): 14526-14529, 2016 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27769116
14.
Enzyme architecture: optimization of transition state stabilization from a cation-phosphodianion pair.
J Am Chem Soc
; 137(16): 5312-5, 2015 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25884759
15.
The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture.
J Am Chem Soc
; 137(3): 1372-82, 2015 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25555107
16.
Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.
Viruses
; 13(2)2021 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33503819
17.
The role of SERPIN citrullination in thrombosis.
Cell Chem Biol
; 28(12): 1728-1739.e5, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34352225