Radial Thermoelectric Model for Stranded Transmission Line Conductors.

Bare-stranded conductors play a critical role in the efficiency and safe operation of transmission lines. The heat generated in the interior of the conductor is conducted radially to the outer surface, creating a radial thermal gradient. The radial temperature gradient between the core and the surface depends on multiple factors, such as stranding, number of layers, current level, electrical resistance and the effective radial thermal conductivity. Therefore, the radial temperature model must be considered when developing accurate conductor models. Such models are particularly important in the development of dynamic line rating (DLR) approaches to allow the full current carrying capacity of the conductor to be utilized while ensuring safe operation. This paper develops a radial one-dimensional thermoelectric model for bare-stranded conductors used in transmission lines. The accuracy of the proposed model is determined by experimental tests performed on three conductors.

Energy Balance of Wireless Sensor Nodes Based on Bluetooth Low Energy and Thermoelectric Energy Harvesting.

The internet of things (IoT) makes it possible to measure physical variables and acquire data in places that were impossible a few years ago, such as transmission lines and electrical substations. Monitoring and fault diagnosis strategies can then be applied. A battery or an energy harvesting system charging a rechargeable battery typically powers IoT devices. The energy harvesting unit and rechargeable battery supply the sensors and wireless communications modules. Therefore, the energy harvesting unit must be correctly sized to optimize the availability and reliability of IoT devices. This paper applies a power balance of the entire IoT device, including the energy harvesting module that includes two thermoelectric generators and a DC-DC converter, the battery, and the sensors and communication modules. Due to the small currents typical of the different communication phases and their fast-switching nature, it is not trivial to measure the energy in each phase, requiring very specific instrumentation. This work shows that using conventional instrumentation it is possible to measure the energy involved in the different modes of communication. A detailed energy balance of the battery is also carried out during charge and discharge cycles, as well as communication modes, from which the maximum allowable data transfer rate is determined. The approach presented here can be generalized to many other smart grid IoT devices.

The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A.

BACKGROUND: The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In this work, we characterize the neuropharmacological effects of salvinorin-A, a highly selective KOR agonist. METHODS: Changes in multimodal electroencephalography, single-photon emission computed tomography, and subjective effects following the acute administration of salvinorin-A are reported. The study included 2 sub-studies that employed a double-blind, crossover, randomized, placebo-controlled design. RESULTS: The electroencephalography measures showed a marked increase in delta and gamma waves and a decrease in alpha waves while subjects were under the effect of salvinorin-A. Regarding single-photon emission computed tomography measures, significant decreases in regional cerebral blood flow were detected in multiple regions of the frontal, temporal, parietal, and occipital cortices. Significant regional cerebral blood flow increases were observed in some regions of the medial temporal lobe, including the amygdala, the hippocampal gyrus, and the cerebellum. The pattern of subjective effects induced by salvinorin-A was similar to those observed in relation to other psychotomimetic drugs but with an evidently dissociative nature. No dysphoric effects were reported. CONCLUSION: The salvinorin-A-mediated KOR agonism induced dramatic psychotomimetic effects along with a generalized decrease in cerebral blood flow and electric activity within the cerebral cortex.

Dopamine modulates the reward experiences elicited by music.

Understanding how the brain translates a structured sequence of sounds, such as music, into a pleasant and rewarding experience is a fascinating question which may be crucial to better understand the processing of abstract rewards in humans. Previous neuroimaging findings point to a challenging role of the dopaminergic system in music-evoked pleasure. However, there is a lack of direct evidence showing that dopamine function is causally related to the pleasure we experience from music. We addressed this problem through a double blind within-subject pharmacological design in which we directly manipulated dopaminergic synaptic availability while healthy participants (n = 27) were engaged in music listening. We orally administrated to each participant a dopamine precursor (levodopa), a dopamine antagonist (risperidone), and a placebo (lactose) in three different sessions. We demonstrate that levodopa and risperidone led to opposite effects in measures of musical pleasure and motivation: while the dopamine precursor levodopa, compared with placebo, increased the hedonic experience and music-related motivational responses, risperidone led to a reduction of both. This study shows a causal role of dopamine in musical pleasure and indicates that dopaminergic transmission might play different or additive roles than the ones postulated in affective processing so far, particularly in abstract cognitive activities.

Application of Image Sensors to Detect and Locate Electrical Discharges: A Review.

Today, there are many attempts to introduce the Internet of Things (IoT) in high-voltage systems, where partial discharges are a focus of concern since they degrade the insulation. The idea is to detect such discharges at a very early stage so that corrective actions can be taken before major damage is produced. Electronic image sensors are traditionally based on charge-coupled devices (CCDs) and, next, on complementary metal oxide semiconductor (CMOS) devices. This paper performs a review and analysis of state-of-the-art image sensors for detecting, locating, and quantifying partial discharges in insulation systems and, in particular, corona discharges since it is an area with an important potential for expansion due to the important consequences of discharges and the complexity of their detection. The paper also discusses the recent progress, as well as the research needs and the challenges to be faced, in applying image sensors in this area. Although many of the cited research works focused on high-voltage applications, partial discharges can also occur in medium- and low-voltage applications. Thus, the potential applications that could potentially benefit from the introduction of image sensors to detect electrical discharges include power substations, buried power cables, overhead power lines, and automotive applications, among others.

Use of DSLR and Sonic Cameras to Detect and Locate High-Voltage Corona Discharges.

Corona discharges are a concern in high-voltage applications. It is of utmost importance to detect and locate the discharges at an early stage using simple methods for this purpose. This paper evaluates and compares the sensitivity of two methods for detecting and locating the source of discharges, which are based on a digital single-lens reflex (DSLR) camera and a portable wideband sonic camera incorporating a matrix of micro-electromechanical systems (MEMS) microphones. Both cameras can generate an image of the studied area where the discharge sites are identified. The study is carried out with different electrode geometries, 50 Hz alternating current (ac) and positive and negative direct current (dc) supplies, and the effect of the distance between the sensor and the discharge sites is also analyzed. The presented results show that the sonic camera enables fast, simple, and sensitive detection and localization of the source of corona discharges even at a very early stage in daylight conditions, regardless of the type of power supply, that is, ac or positive/negative dc, and at distance of several meters from the discharge source.

Measurement of Corona Discharges under Variable Geometry, Frequency and Pressure Environment.

Aeronautical industry is evolving towards more electric aircrafts (MEA), which will require much more electrical power compared to conventional models. To satisfy this increasing power demand and stringent weight requirements, distribution voltages must be raised, which jointly with the low-pressure environment and high operating frequencies increase the risk of electrical discharges occurrence. Therefore, it is important to generate data to design insulation systems for these demanding applications. To this end, in this work a sphere-to-plane electrode configuration is tested for several sphere geometries (diameters ranging from 2 mm to 10 mm), frequencies of 50 Hz, 400 Hz and 800 Hz and pressures in the 20-100 kPa range, to cover most aircraft applications. The corona extinction voltage is experimentally determined by using a gas-filled tube solar blind ultraviolet (UV) sensor. In addition, a CMOS imaging sensor is used to locate the discharge points. Next, to gain further insight to the discharge conditions, the electric field strength is calculated using finite element method (FEM) simulations and fitted to equations based on Peek's law. The results presented in this paper could be especially valuable to design aircraft electrical insulations as well as for high-voltage hardware manufacturers, since the results allow determining the electric field values at which the components can operate free of surface discharges for a wide altitude range.

Performance Evaluation of Solar-Blind Gas-Filled Sensors to Detect Electrical Discharges for Low-Pressure Aircraft Applications.

Unpressurized aircraft circuits facilitate the initiation of electrical discharges in wiring systems, with consequent damage to related insulation materials and safety hazards, that can and have already caused severe incidents and accidents. Specific sensors and solutions must be developed to detect these types of faults at a very incipient stage, before further damage occurs. Electrical discharges in air generate the corona effect, which is characterized by emissions of bluish light, which are found in the ultraviolet (UV) and visible spectra. However, due to sunlight interference, the corona effect is very difficult to detect at the very initial stage, so the use of solar-blind sensors can be a possible solution. This work analyzes the feasibility of using inexpensive non-invasive solar-blind sensors in a range of pressures compatible with aircraft environments to detect the electrical discharges at a very incipient stage. Their behavior and sensitivity compared with other alternatives, i.e., an antenna sensor and a CMOS imaging sensor, is also assessed. Experimental results presented in this paper show that the analyzed solar-blind sensors can be applied for the on-line detection of electrical discharges in unpressurized aircraft environments at the very initial stage, thus facilitating and enabling the application of predictive maintenance strategies. They also offer the possibility to be combined with existing electrical protections to expand their capabilities and improve their sensitivity to detect very early discharges, thus allowing the timely identification of their occurrence.

CNN-LSTM-Based Prognostics of Bidirectional Converters for Electric Vehicles' Machine.

This paper proposes an approach to estimate the state of health of DC-DC converters that feed the electrical system of an electric vehicle. They have an important role in providing a smooth and rectified DC voltage to the electric machine. Thus, it is important to diagnose the actual status and predict the future performance of the converter and specifically of the electrolytic capacitors, in order to avoid malfunctioning and failures, since it is known they have the highest failure rates among power converter components. To this end, accelerated aging tests of the electrolytic capacitors are performed by applying an electrical overstress. The gathered data are used to train a CNN-LSTM model that is capable of predicting the future values of the capacitance and the equivalent series resistance (ESR) of the electrolytic capacitor. This model can be used to estimate the remaining useful life of the device, thus, increasing the reliability of the system and ensuring an adequate operating condition of the electric motor.

Analysis of a Smart Sensor Based Solution for Smart Grids Real-Time Dynamic Thermal Line Rating.

Dynamic thermal line rating (DTLR) allows us to take advantage of the maximum transmission capacity of power lines, which is an imperious need for future smart grids. This paper proposes a real-time method to determine the DTLR rating of aluminum conductor steel-reinforced (ACSR) conductors. The proposed approach requires a thermal model of the line to determine the real-time values of the solar radiation and the ambient temperature, which can be obtained from weather stations placed near the analyzed conductors as well as the temperature and the current of the conductor, which can be measured directly with a Smartconductor and can be transmitted wirelessly to a nearby gateway. Real-time weather and overhead line data monitoring and the calculation of DTLR ratings based on models of the power line is a practical smart grid application. Since it is known that the wind speed exhibits important fluctuations, even in nearby areas, and since it plays a key role in determining the DTLR, it is essential to accurately estimate this parameter at the conductor's location. This paper presents a method to estimate the wind speed and the DTLR rating of the analyzed conductor. Experimental tests have been conducted to validate the accuracy of the proposed approach using ACSR conductors.

On-Line Remaining Useful Life Estimation of Power Connectors Focused on Predictive Maintenance.

Connections are critical elements in power systems, exhibiting higher failure probability. Power connectors are considered secondary simple devices in power systems despite their key role, since a failure in one such element can lead to major issues. Thus, it is of vital interest to develop predictive maintenance approaches to minimize these issues. This paper proposes an on-line method to determine the remaining useful life (RUL) of power connectors. It is based on a simple and accurate model of the degradation with time of the electrical resistance of the connector, which only has two parameters, whose values are identified from on-line acquired data (voltage drop across the connector, electric current and temperature). The accuracy of the model presented in this paper is compared with the widely applied autoregressive integrated moving average model (ARIMA), showing enhanced performance. Next, a criterion to determine the RUL is proposed, which is based on the inflection point of the expression describing the electrical resistance degradation. This strategy allows determination of when the connector must be replaced, thus easing predictive maintenance tasks. Experimental results from seven connectors show the potential and viability of the suggested method, which can be applied to many other devices.

Corona Discharge Characteristics under Variable Frequency and Pressure Environments.

More electric aircrafts (MEAs) are paving the path to all electric aircrafts (AEAs), which make a much more intensive use of electrical power than conventional aircrafts. Due to the strict weight requirements, both MEA and AEA systems require to increase the distribution voltage in order to limit the required electrical current. Under this paradigm new issues arise, in part due to the voltage rise and in part because of the harsh environments found in aircrafts systems, especially those related to low pressure and high-electric frequency operation. Increased voltage levels, high-operating frequencies, low-pressure environments and reduced distances between wires pose insulation systems at risk, so partial discharges (PDs) and electrical breakdown are more likely to occur. This paper performs an experimental analysis of the effect of low-pressure environments and high-operating frequencies on the visual corona voltage, since corona discharges occurrence is directly related to arc tracking and insulation degradation in wiring systems. To this end, a rod-to-plane electrode configuration is tested in the 20-100 kPa and 50-1000 Hz ranges, these ranges cover most aircraft applications, so that the corona extinction voltage is experimentally determined by using a low-cost high-resolution CMOS imaging sensor which is sensitive to the visible and near ultraviolet (UV) spectra. The imaging sensor locates the discharge points and the intensity of the discharge, offering simplicity and low-cost measurements with high sensitivity. Moreover, to assess the performance of such sensor, the discharges are also acquired by analyzing the leakage current using an inexpensive resistor and a fast oscilloscope. The experimental data presented in this paper can be useful in designing insulation systems for MEA and AEA applications.

Arc Tracking Control in Insulation Systems for Aeronautic Applications: Challenges, Opportunities, and Research Needs.

Next generation aircrafts will use more electrical power to reduce weight, fuel consumption, system complexity and greenhouse gas emissions. However, new failure modes and challenges arise related to the required voltage increase and consequent rise of electrical stress on wiring insulation materials, thus increasing the risk of electrical arc appearance. This work performs a critical and comprehensive review concerning arc tracking effects in wiring insulation systems, underlying mechanisms, role of materials and possible mitigation strategies, with a special focus on aircraft applications. To this end an evaluation of the scientific and technological state of the art is carried out from the analysis of theses, research articles, technical reports, international standards and white papers. This review paper also reports the limitations of existing insulation materials, standard test methods and mitigation approaches, while identifying the research needs to comply with the future demands of the aircraft industry.

Experimental Study of Visual Corona under Aeronautic Pressure Conditions Using Low-Cost Imaging Sensors.

Visual corona tests have been broadly applied for identifying the critical corona points of diverse high-voltage devices, although other approaches based on partial discharge or radio interference voltage measurements are also widely applied to detect corona activity. Nevertheless, these two techniques must be applied in screened laboratories, which are scarce and expensive, require sophisticated instrumentation, and typically do not allow location of the discharge points. This paper describes the detection of the visual corona and location of the critical corona points of a sphere-plane gap configurations under different pressure conditions ranging from 100 to 20 kPa, covering the pressures typically found in aeronautic environments. The corona detection is made with a low-cost CMOS imaging sensor from both the visible and ultraviolet (UV) spectrum, which allows detection of the discharge points and their locations, thus significantly reducing the complexity and costs of the instrumentation required while preserving the sensitivity and accuracy of the measurements. The approach proposed in this paper can be applied in aerospace applications to prevent the arc tracking phenomenon, which can lead to catastrophic consequences since there is not a clear protection solution, due to the low levels of leakage current involved in the pre-arc phenomenon.

Insulation Failure Quantification Based on the Energy of Digital Images Using Low-Cost Imaging Sensors.

Insulation faults in high-voltage applications often generate partial discharges (PDs) accompanied by corona activity, optical radiation mainly in the ultraviolet (UV) and visible bands. Recent developments in low-cost, small-size, and high-resolution visible imaging sensors, which are also partially sensitive to the UV spectral region, are gaining attention due to their many industrial applications. This paper proposes a method for early PD detection by using digital imaging sensors, which allows the severity of insulation faults to be assessed. The electrical power dissipated by the PDs is correlated to the energy of the acquired visible images, and thus, the severity of insulation faults is determined from the energy of the corona effect. A criterion to quantify the severity of insulation faults based on the energy of the corona images is proposed. To this end, the point-to-plane gap configuration is analyzed in a low-pressure chamber, where digital image photographs of the PDs are taken and evaluated under different pressure conditions ranging from 10 to 100 kPa, which cover the typical pressure range of aeronautic applications. The use of digital imaging sensors also allows an early detection, location and quantification of the PD activity, and thus assessing the severity of insulation faults to perform predictive maintenance tasks, while enabling the cost and complexity of the instrumentation to be reduced. Although the approach proposed in this paper has been applied to detect PDs in aeronautic applications, it can be applied to many other high-voltage applications susceptible of PD occurrence.

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial.

BACKGROUND: Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. METHODS: To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating scale at baseline, and at 1 (D1), 2 (D2), and 7 (D7) days after dosing. RESULTS: We observed significant antidepressant effects of ayahuasca when compared with placebo at all-time points. MADRS scores were significantly lower in the ayahuasca group compared with placebo at D1 and D2 (p = 0.04), and at D7 (p < 0.0001). Between-group effect sizes increased from D1 to D7 (D1: Cohen's d = 0.84; D2: Cohen's d = 0.84; D7: Cohen's d = 1.49). Response rates were high for both groups at D1 and D2, and significantly higher in the ayahuasca group at D7 (64% v. 27%; p = 0.04). Remission rate showed a trend toward significance at D7 (36% v. 7%, p = 0.054). CONCLUSIONS: To our knowledge, this is the first controlled trial to test a psychedelic substance in treatment-resistant depression. Overall, this study brings new evidence supporting the safety and therapeutic value of ayahuasca, dosed within an appropriate setting, to help treat depression. This study is registered at http://clinicaltrials.gov (NCT02914769).

Validation of a Spanish version of the Schizotypal Personality Questionnaire (SPQ): Psychometric characteristics and underlying factor structure derived from a healthy university student sample.

OBJECTIVE: The need for early detection, prevention and intervention in psychosis has prompted the study of prodromal and threshold syndromes. One strategy involves the assessment of schizotypy, a personality construct involving unusual perceptual experiences, magical thinking or bizarre behavior. Sensitive measurement instruments could potentially allow detection of signs heralding transition to psychosis in high-risk individuals, or risk of relapse in patients after a first psychotic episode. The Schizotypal Personality Questionnaire (SPQ) is a self-report scale, originally developed for English speakers, that covers the nine DSM-IV criteria for schizotypal personality disorder (SPD). Our aim was to validate a Spanish version of the SPQ and assess its psychometric properties. METHODS: The original SPQ was back-translated and administered to university students (n=250). We assessed the internal consistency, the convergent, discriminant and criterion validity of the instrument, and analyzed its factor structure. RESULTS: Our version of the SPQ showed good internal consistency, and convergent (O-LIFE), discriminant (P-scale of EPQ) and criterion validity (SCID-II). Factor analyses supported a four-factor structure in fitting SPQ data. CONCLUSIONS: Our Spanish version of the SPQ questionnaire preserved the psychometric properties of the original questionnaire. This adaptation will provide a useful tool for the early detection of prodromal schizophrenia symptoms and clinical relapse in Spanish-speaking populations.

Assessing the Psychedelic "After-Glow" in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities.

Background: Ayahuasca is a plant tea containing the psychedelic 5-HT2A agonist N,N-dimethyltryptamine and harmala monoamine-oxidase inhibitors. Acute administration leads to neurophysiological modifications in brain regions of the default mode network, purportedly through a glutamatergic mechanism. Post-acutely, ayahuasca potentiates mindfulness capacities in volunteers and induces rapid and sustained antidepressant effects in treatment-resistant patients. However, the mechanisms underlying these fast and maintained effects are poorly understood. Here, we investigated in an open-label uncontrolled study in 16 healthy volunteers ayahuasca-induced post-acute neurometabolic and connectivity modifications and their association with mindfulness measures. Methods: Using 1H-magnetic resonance spectroscopy and functional connectivity, we compared baseline and post-acute neurometabolites and seed-to-voxel connectivity in the posterior and anterior cingulate cortex after a single ayahuasca dose. Results: Magnetic resonance spectroscopy showed post-acute reductions in glutamate+glutamine, creatine, and N-acetylaspartate+N-acetylaspartylglutamate in the posterior cingulate cortex. Connectivity was increased between the posterior cingulate cortex and the anterior cingulate cortex, and between the anterior cingulate cortex and limbic structures in the right medial temporal lobe. Glutamate+glutamine reductions correlated with increases in the "nonjudging" subscale of the Five Facets Mindfulness Questionnaire. Increased anterior cingulate cortex-medial temporal lobe connectivity correlated with increased scores on the self-compassion questionnaire. Post-acute neural changes predicted sustained elevations in nonjudging 2 months later. Conclusions: These results support the involvement of glutamate neurotransmission in the effects of psychedelics in humans. They further suggest that neurometabolic changes in the posterior cingulate cortex, a key region within the default mode network, and increased connectivity between the anterior cingulate cortex and medial temporal lobe structures involved in emotion and memory potentially underlie the post-acute psychological effects of ayahuasca.

Cocaine addiction is associated with abnormal prefrontal function, increased striatal connectivity and sensitivity to monetary incentives, and decreased connectivity outside the human reward circuit.

Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the human reward circuit in abstinent cocaine-dependent (CD) patients and their matched controls. We assessed the BOLD response to monetary gains and losses in 30 CD patients and 30 healthy controls performing a lottery task in a magnetic resonance imaging scanner. We measured brain gray matter volume (GMV) using voxel-based morphometry and white matter microstructure using voxel-based fractional anisotropy (FA). Functional data showed that, after monetary incentives, CD patients exhibited higher activation in the ventral striatum than controls. Furthermore, we observed an inverted BOLD response pattern in the prefrontal cortex, with activity being highest after unexpected high gains and lowest after losses. Patients showed increased GMV in the caudate and the orbitofrontal cortex, increased white matter FA in the orbito-striatal pathway but decreased FA in antero-posterior association bundles. Abnormal activation in the prefrontal cortex correlated with GMV and FA increases in the orbitofrontal cortex. While functional abnormalities in the ventral striatum were inversely correlated with abstinence duration, structural alterations were not. In conclusion, results suggest abnormal incentive processing in CD patients with high salience for rewards and punishments in subcortical structures but diminished prefrontal control after adverse outcomes. They further suggest that hypertrophy and hyper-connectivity within the reward circuit, to the expense of connectivity outside this network, characterize cocaine addiction.

Naltrexone but Not Ketanserin Antagonizes the Subjective, Cardiovascular, and Neuroendocrine Effects of Salvinorin-A in Humans.

BACKGROUND: Salvinorin-A is a terpene found in the leaves of the plant Salvia divinorum. When administered to humans, salvinorin-A induces an intense but short-lasting modified state of awareness, sharing features with those induced by the classical serotonin-2A receptor agonist psychedelics. However, unlike substances such as psilocybin or mescaline, salvinorin-A shows agonist activity at the kappa-opioid receptor rather than at the serotonin-2A receptor. Here, we assessed the involvement of kappa-opioid receptor and serotonin-2A agonism in the subjective, cardiovascular, and neuroendocrine effects of salvinorin-A in humans. METHODS: We conducted a placebo-controlled, randomized, double-blind study with 2 groups of 12 healthy volunteers with experience with psychedelic drugs. There were 4 experimental sessions. In group 1, participants received the following treatment combinations: placebo+placebo, placebo+salvinorin-A, naltrexone+placebo, and naltrexone+salvinorin-A. Naltrexone, a nonspecific opioid receptor antagonist, was administered at a dose of 50mg orally. In group 2, participants received the treatment combinations: placebo+placebo, placebo+salvinorin-A, ketanserin+placebo, and ketanserin+salvinorin-A. Ketanserin, a selective serotonin-2A antagonist, was administered at a dose of 40mg orally. RESULTS: Inhalation of 1mg of vaporized salvinorin-A led to maximum plasma concentrations at 1 and 2 minutes after dosing. When administered alone, salvinorin-A severely reduced external sensory perception and induced intense visual and auditory modifications, increased systolic blood pressure, and cortisol and prolactin release. These effects were effectively blocked by naltrexone, but not by ketanserin. CONCLUSIONS: Results support kappa opioid receptor agonism as the mechanism of action underlying the subjective and physiological effects of salvinorin-A in humans and rule out the involvement of a serotonin-2A-mediated mechanism.