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1.

Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial.

McIlroy, Graham; Lax, Siân; Gaskell, Charlotte; Jackson, Aimee; Rhodes, Malcolm; Seale, Tania; Fox, Sonia; Hopkins, Lousie; Okosun, Jessica; Barrington, Sally F; Ringshausen, Ingo; Ramsay, Alan G; Calaminici, Maria; Linton, Kim; Bishton, Mark.

BMC Cancer ; 24(1): 370, 2024 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-38528445

2.

ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia.

Chen, Jingyu; Sathiaseelan, Vijitha; Moore, Andrew; Tan, Shengjiang; Chilamakuri, Chandra Sekkar Reddy; Roamio Franklin, Valar Nila; Shahsavari, Arash; Jakwerth, Constanze A; Hake, Sandra B; Warren, Alan J; Mohorianu, Irina; D'Santos, Clive; Ringshausen, Ingo.

Blood ; 137(26): 3629-3640, 2021 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-33619528

3.

Bone Marrow Stromal Cells Drive Key Hallmarks of B Cell Malignancies.

Mangolini, Maurizio; Ringshausen, Ingo.

Int J Mol Sci ; 21(4)2020 Feb 21.

Artigo em Inglês | MEDLINE | ID: mdl-32098106

4.

IL-9 in CLL: sensing home and settling down!

Ringshausen, Ingo.

Blood ; 137(16): 2130-2131, 2021 04 22.

Artigo em Inglês | MEDLINE | ID: mdl-33885714

5.

Integration of innate into adaptive immune responses in ZAP-70-positive chronic lymphocytic leukemia.

Wagner, Michaela; Oelsner, Madlen; Moore, Andrew; Götte, Frederik; Kuhn, Peer-Hendrik; Haferlach, Torsten; Fiegl, Michael; Bogner, Christian; Baxter, E Joanna; Peschel, Christian; Follows, George A; Ringshausen, Ingo.

Blood ; 127(4): 436-48, 2016 Jan 28.

Artigo em Inglês | MEDLINE | ID: mdl-26508782

6.

Clinical challenge: fatal mucormycotic osteomyelitis caused by Rhizopus microsporus despite aggressive multimodal treatment.

Harrasser, Norbert; Banke, Ingo J; Hauschild, Matthias; Lenze, Ulrich; Prodinger, Peter M; Toepfer, Andreas; Peschel, Christian; von Eisenhart-Rothe, Rüdiger; Ringshausen, Ingo; Verbeek, Mareike.

BMC Infect Dis ; 14: 488, 2014 Sep 06.

Artigo em Inglês | MEDLINE | ID: mdl-25195155

7.

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

Ringshausen, Ingo; O'Shea, Clodagh C; Finch, Andrew J; Swigart, Lamorna Brown; Evan, Gerard I.

Cancer Cell ; 10(6): 501-14, 2006 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-17157790

8.

ZAP-70 augments tonic B-cell receptor and CCR7 signaling in IGHV-unmutated chronic lymphocytic leukemia.

Chen, Jingyu; Sathiaseelan, Vijitha; Reddy Chilamakuri, Chandra Sekkar; Roamio Franklin, Valar Nila; Jakwerth, Constanze A; D'Santos, Clive; Ringshausen, Ingo.

Blood Adv ; 8(5): 1167-1178, 2024 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-38113463

9.

Guideline for the treatment of chronic lymphocytic leukaemia: A British Society for Haematology Guideline.

Schuh, Anna H; Parry-Jones, Nilima; Appleby, Niamh; Bloor, Adrian; Dearden, Claire E; Fegan, Christopher; Follows, George; Fox, Christopher P; Iyengar, Sunil; Kennedy, Ben; McCarthy, Helen; Parry, Helen M; Patten, Piers; Pettitt, Andrew R; Ringshausen, Ingo; Walewska, Renata; Hillmen, Peter.

Br J Haematol ; 182(3): 344-359, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-30009455

10.

Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression.

Ecker, Veronika; Brandmeier, Lisa; Stumpf, Martina; Giansanti, Piero; Moreira, Aida Varela; Pfeuffer, Lisa; Fens, Marcel H A M; Lu, Junyan; Kuster, Bernhard; Engleitner, Thomas; Heidegger, Simon; Rad, Roland; Ringshausen, Ingo; Zenz, Thorsten; Wendtner, Clemens-Martin; Müschen, Markus; Jellusova, Julia; Ruland, Jürgen; Buchner, Maike.

Cell Rep ; 42(10): 113017, 2023 10 31.

Artigo em Inglês | MEDLINE | ID: mdl-37792532

11.

BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib.

Bonfiglio, Silvia; Sutton, Lesley-Ann; Ljungström, Viktor; Capasso, Antonella; Pandzic, Tatjana; Weström, Simone; Foroughi-Asl, Hassan; Skaftason, Aron; Gellerbring, Anna; Lyander, Anna; Gandini, Francesca; Gaidano, Gianluca; Trentin, Livio; Bonello, Lisa; Reda, Gianluigi; Bödör, Csaba; Stavroyianni, Niki; Tam, Constantine S; Marasca, Roberto; Forconi, Francesco; Panayiotidis, Panayiotis; Ringshausen, Ingo; Jaksic, Ozren; Frustaci, Anna Maria; Iyengar, Sunil; Coscia, Marta; Mulligan, Stephen P; Ysebaert, Loïc; Strugov, Vladimir; Pavlovsky, Carolina; Walewska, Renata; Österborg, Anders; Cortese, Diego; Ranghetti, Pamela; Baliakas, Panagiotis; Stamatopoulos, Kostas; Scarfò, Lydia; Rosenquist, Richard; Ghia, Paolo.

Blood Adv ; 7(12): 2794-2806, 2023 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-36696464

12.

The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-ßII depletion.

Biberacher, Viola; Decker, Thomas; Oelsner, Madlen; Wagner, Michaela; Bogner, Christian; Schmidt, Burkhard; Kreitman, Robert J; Peschel, Christian; Pastan, Ira; Meyer Zum Büschenfelde, Christian; Ringshausen, Ingo.

Haematologica ; 97(5): 771-9, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22180432

13.

Transforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma.

Timmins, Matthew A; Ringshausen, Ingo.

Cancers (Basel) ; 14(7)2022 Mar 31.

Artigo em Inglês | MEDLINE | ID: mdl-35406544

14.

Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.

Mangolini, Maurizio; Maiques-Diaz, Alba; Charalampopoulou, Stella; Gerhard-Hartmann, Elena; Bloehdorn, Johannes; Moore, Andrew; Giachetti, Giorgia; Lu, Junyan; Roamio Franklin, Valar Nila; Chilamakuri, Chandra Sekkar Reddy; Moutsopoulos, Ilias; Rosenwald, Andreas; Stilgenbauer, Stephan; Zenz, Thorsten; Mohorianu, Irina; D'Santos, Clive; Deaglio, Silvia; Hodson, Daniel J; Martin-Subero, Jose I; Ringshausen, Ingo.

Nat Commun ; 13(1): 6220, 2022 10 20.

Artigo em Inglês | MEDLINE | ID: mdl-36266281

15.

MYC sensitises cells to apoptosis by driving energetic demand.

Edwards-Hicks, Joy; Su, Huizhong; Mangolini, Maurizio; Yoneten, Kubra K; Wills, Jimi; Rodriguez-Blanco, Giovanny; Young, Christine; Cho, Kevin; Barker, Heather; Muir, Morwenna; Guerrieri, Ania Naila; Li, Xue-Feng; White, Rachel; Manasterski, Piotr; Mandrou, Elena; Wills, Karen; Chen, Jingyu; Abraham, Emily; Sateri, Kianoosh; Qian, Bin-Zhi; Bankhead, Peter; Arends, Mark; Gammoh, Noor; von Kriegsheim, Alex; Patti, Gary J; Sims, Andrew H; Acosta, Juan Carlos; Brunton, Valerie; Kranc, Kamil R; Christophorou, Maria; Pearce, Erika L; Ringshausen, Ingo; Finch, Andrew J.

Nat Commun ; 13(1): 4674, 2022 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-35945217

16.

Matching-adjusted indirect comparisons of safety and efficacy of acalabrutinib versus other targeted therapies in patients with treatment-naïve chronic lymphocytic leukemia.

Davids, Matthew S; Telford, Claire; Abhyankar, Sarang; Waweru, Catherine; Ringshausen, Ingo.

Leuk Lymphoma ; 62(10): 2342-2351, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-33955326

17.

Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.

Ecker, Veronika; Stumpf, Martina; Brandmeier, Lisa; Neumayer, Tanja; Pfeuffer, Lisa; Engleitner, Thomas; Ringshausen, Ingo; Nelson, Nina; Jücker, Manfred; Wanninger, Stefan; Zenz, Thorsten; Wendtner, Clemens; Manske, Katrin; Steiger, Katja; Rad, Roland; Müschen, Markus; Ruland, Jürgen; Buchner, Maike.

Nat Commun ; 12(1): 3526, 2021 06 10.

Artigo em Inglês | MEDLINE | ID: mdl-34112805

18.

Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia.

Lu, Junyan; Cannizzaro, Ester; Meier-Abt, Fabienne; Scheinost, Sebastian; Bruch, Peter-Martin; Giles, Holly Ar; Lütge, Almut; Hüllein, Jennifer; Wagner, Lena; Giacopelli, Brian; Nadeu, Ferran; Delgado, Julio; Campo, Elías; Mangolini, Maurizio; Ringshausen, Ingo; Böttcher, Martin; Mougiakakos, Dimitrios; Jacobs, Andrea; Bodenmiller, Bernd; Dietrich, Sascha; Oakes, Christopher C; Zenz, Thorsten; Huber, Wolfgang.

Nat Cancer ; 2(8): 853-864, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34423310

19.

Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression.

Bogner, Christian; Dechow, Tobias; Ringshausen, Ingo; Wagner, Michaela; Oelsner, Madlen; Lutzny, Gloria; Licht, Thomas; Peschel, Christian; Pastan, Ira; Kreitman, Robert J; Decker, Thomas.

Br J Haematol ; 148(1): 99-109, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19821820

20.

Antiapoptotic effect of interleukin-2 (IL-2) in B-CLL cells with low and high affinity IL-2 receptors.

Decker, Thomas; Bogner, Christian; Oelsner, Madlen; Peschel, Christian; Ringshausen, Ingo.

Ann Hematol ; 89(11): 1125-32, 2010 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20544350

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