Detalhe da pesquisa
1.
Structural analysis and biological activities of C25-amino and C25-nitro vitamin D analogs.
Bioorg Chem
; 136: 106528, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37054528
2.
Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer.
Nucleic Acids Res
; 48(19): 11199-11213, 2020 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32990725
3.
Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR.
Nucleic Acids Res
; 48(17): 9969-9985, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32974652
4.
Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants.
Int J Mol Sci
; 23(15)2022 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35955580
5.
Design, Synthesis, Evaluation and Structure of Allenic 1α,25-Dihydroxyvitamin D3 Analogs with Locked Mobility at C-17.
Chemistry
; 27(53): 13384-13389, 2021 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34224173
6.
Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR).
Bioorg Chem
; 115: 105202, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34339974
7.
Lithocholic acid-based design of noncalcemic vitamin D receptor agonists.
Bioorg Chem
; 111: 104878, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33853023
8.
Biological evaluation and synthesis of calcitroic acid.
Bioorg Chem
; 116: 105310, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34482171
9.
Structural Basis for α-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers.
Angew Chem Int Ed Engl
; 60(5): 2296-2303, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32935897
10.
Corrigendum to "Lithocholic acid-based design of noncalcemic vitamin D receptor agonists" [Bioorg. Chem. 111 (2021) 104878].
Bioorg Chem
; 136: 106559, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148869
11.
9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice.
PLoS Genet
; 11(6): e1005213, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26030625
12.
Solution Behavior of the Intrinsically Disordered N-Terminal Domain of Retinoid X Receptor α in the Context of the Full-Length Protein.
Biochemistry
; 55(12): 1741-1748, 2016 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937780
13.
Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA.
EMBO J
; 31(2): 291-300, 2012 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22179700
14.
Architecture of DNA Bound RAR heterodimers.
Subcell Biochem
; 70: 21-36, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24962879
15.
Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
Proc Natl Acad Sci U S A
; 109(10): E588-94, 2012 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22355136
16.
Structure-function relationships in nuclear receptors: the facts.
Trends Biochem Sci
; 40(6): 287-90, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25899756
17.
Phosphorylation of the retinoic acid receptor alpha induces a mechanical allosteric regulation and changes in internal dynamics.
PLoS Comput Biol
; 9(4): e1003012, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23637584
18.
The use of fluorescent intrabodies to detect endogenous gankyrin in living cancer cells.
Exp Cell Res
; 319(6): 838-49, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23353833
19.
4-Hydroxy-1α,25-Dihydroxyvitamin D3: Synthesis and Structure-Function Study.
Biomolecules
; 14(5)2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38785958
20.
Design, synthesis, and biological activity of D-bishomo-1α,25-dihydroxyvitamin D3 analogs and their crystal structures with the vitamin D nuclear receptor.
Eur J Med Chem
; 271: 116403, 2024 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38615411