Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas.

BACKGROUND: We aimed to determine whether living in a household with children is associated with SARS-CoV-2 seropositivity in adults and investigated interacting factors that may influence this association. METHODS: SARS-CoV-2 serology testing was performed in randomly selected individuals from the general population between end of October 2020 and February 2021 in 11 cantons in Switzerland. Data on sociodemographic and household characteristics, employment status, and health-related history was collected using questionnaires. Multivariable logistic regression was used to examine the association of living with children <18 years of age (number, age group) and SARS-CoV-2 seropositivity. Further, we assessed the influence of reported non-household contacts, employment status, and gender. RESULTS: Of 2393 working age participants (18-64 years), 413 (17.2%) were seropositive. Our results suggest that living with children and SARS-CoV-2 seropositivity are likely to be associated (unadjusted odds ratio (OR) 1.22, 95% confidence interval [0.98-1.52], adjusted OR 1.25 [0.99-1.58]). A pattern of a positive association was also found for subgroups of children aged 0-11 years (OR 1.21 [0.90-1.60]) and 12-17 years (OR 1.14 [0.78-1.64]). Odds of seropositivity were higher with more children (OR 1.14 per additional child [1.02-1.27]). Men had higher risk of SARS-CoV-2 infection when living with children than women (interaction: OR 1.74 [1.10-2.76]). CONCLUSIONS: In adults from the general population living with children seems associated with SARS-CoV-2 seropositivity. However, child-related infection risk is not the same for every subgroup and depends on factors like gender. Further factors determining child-related infection risk need to be identified and causal links investigated. TRIAL REGISTRATION: https://www.isrctn.com/ISRCTN18181860 .

Are mind-body therapies effective for relieving cancer-related pain in adults? A systematic review and meta-analysis.

OBJECTIVE: To assess whether mind-body therapies are effective for relieving cancer-related pain in adults, since at least one-third of adults with cancer are affected by moderate or severe pain. METHODS: We searched for all randomized or quasi-randomized controlled trials that included adults (≥18 years) with cancer-related pain who were treated with mind-body therapies (mindfulness, hypnosis, yoga, guided imagery, and progressive muscle relaxation) in MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL), Science Citation Index, Web of Science, trials registers, and reference lists. The primary outcome was pain intensity. We calculated the standardized mean differences and 95% confidence intervals (CIs) and assessed the risk of bias. RESULTS: We identified 40 primary studies involving a total of 3569 participants. The meta-analysis included 24 studies (2404 participants) and showed a significant effect of -0.39 (95% CI -0.62 to -0.16) with considerable heterogeneity (I2  = 86.3%, p < 0.001). After we excluded four "outlier" studies in sensitivity analyses, the effect size remained significant but weaker. There was a high risk of bias in all studies, for example, performance bias due to lack of participant blinding. Patients in multiple settings were included but many studies were of low quality. CONCLUSIONS: Mind-body therapies may be effective in improving cancer pain, but the quality of the evidence is low. There is a need for further high-quality clinical trials.

[Integrative medicine: scientific literature in 2021]. / Médecine integrative - Littérature scientifique en 2021.

To illustrate the novelties in integrative and complementary medicine in 2021, the authors present a selection of six articles. One of them is specifically related to COVID-19. The other articles deal with themes that are always relevant and where complementary approaches represent a real added value. Two articles focus on low back pain, a common problem in primary care medicine. The others examine acupuncture in the oncological context, the use of therapeutic suggestions in an operative context, and Tai Chi. The authors thus provide an overview of the range of possible complementary therapeutic approaches that are increasingly supported by evidence, inviting them to be better integrated into clinical practice.

Pour illustrer les nouveautés en médecine intégrative et complémentaire en 2021, les auteur·e·s présentent une sélection de six articles. L'un s'intéresse plus spécifiquement au Covid-19. Les autres touchent des thématiques qui restent toujours d'actualité et où des approches complémentaires peuvent représenter une réelle plus-value. Deux articles ont pour thème les lombalgies, problématique courante en médecine de premier recours. Les autres examinent l'acupuncture dans le contexte oncologique, l'utilisation de suggestions thérapeutiques dans un contexte opératoire, et le Tai Chi. Les auteur·e·s donnent ainsi un aperçu de l'éventail d'approches thérapeutiques complémentaires possibles et de plus en plus soutenues par la science, invitant à les intégrer de mieux en mieux dans la pratique clinique.

[Scientific literature on integrative medicine in 2020]. / Littérature scientifique concernant la médecine intégrative en 202.

Scientific research in integrative medicine has undergone significant development in recent years. Several studies published in 2020 focus on the management of chronic pain. Hypnosis has been shown to be as effective in analgesia as cognitive-behavioral therapy and therapeutic education. A study on chronic low back pain showed lower health care costs for patients using complementary medicine. Furthermore, the hypothesis of super responders to acupuncture treatment does not seem to be confirmed. Yoga could be a useful approach in the prevention of migraines. With respect to the management of COVID-19, the addition of traditional Chinese medicine to conventional treatments could reduce a number of symptoms and the length of hospital stays, although the quality of data is limited.

La recherche en médecine intégrative connaît un développement important depuis quelques années. Plusieurs études publiées en 2020 concernent la prise en charge de la douleur chronique. L'hypnose s'est montrée aussi efficace contre la douleur que la thérapie cognitivo-comportementale et l'éducation thérapeutique. Une étude sur les lombalgies chroniques a indiqué des dépenses de santé plus basses pour les patients recourant aux médecines complémentaires. Par ailleurs, l'hypothèse de super-répondeurs à un traitement d'acupuncture ne semble pas se confirmer. Le yoga pourrait être une approche utile dans la prévention des migraines. En ce qui concerne la prise en charge du Covid-19, l'ajout de la médecine traditionnelle chinoise pourrait diminuer certains symptômes et la durée des hospitalisations, bien que la qualité des données reste limitée.

[Pediatric integrative medicine is an integral part of child health care in Switzerland]. / La pédiatrie intégrative fait partie intégrante des soins pédiatriques en Suisse.

Based on evidence and experience, pediatric integrative medicine uses conventional and complementary therapies in an interprofessional approach to optimally support health and development of children and adolescents. Switzerland has a high standard of child health care including complementary medicine. Many pediatricians and family physicians offer an integrative approach to their patients based on additional trainings in complementary medicine, which ensures a full and competent medical care. The Swiss Interest Group for Integrative Pediatrics of the Swiss Society of Pediatrics deals with all questions relating to complementary and integrative medicine in pediatrics including the organization of training events and the coordination of research projects.

Basée sur l'évidence et l'expérience, la pédiatrie intégrative utilise des thérapies conventionnelles et complémentaires dans une approche interprofessionnelle, pour promouvoir de manière optimale le développement et la santé des enfants et adolescents. La Suisse dispose d'un niveau élevé de soins pédiatriques incluant la médecine complémentaire. De nombreux pédiatres et médecins de famille offrent une approche intégrative aux patients, basée sur des formations supplémentaires en médecine complémentaire, ce qui garantit une prise en charge large et compétente. Le Groupe d'intérêt suisse pour la pédiatrie intégrative de la Société suisse de pédiatrie traite de toutes les questions relatives à la médecine complémentaire et l'approche intégrative en pédiatrie, y compris l'organisation des formations et la coordination de la recherche.

[Acute respiratory and urinary tract infections in medical practice†: a selection of complementary medicines]. / Infections aiguës des voies respiratoires et urinaires au cabinet médical†: quelques traitements en médecine complémentaire.

Respiratory tract infections such as bronchitis or sinusitis and urinary tract infections are common in the family doctor's office. Bronchitis and sinusitis are mostly of viral origin and antibiotics rarely hold a place in their management, while urinary tract infections most often require the prescription of antibiotics. In both situations, patients often seek complementary medicines to relieve symptoms or prevent recurrences. This article aims to synthesize available data on efficacy and safety of some treatments in complementary medicine used in these indications, such as South African geranium, the combination of thyme-primrose or thyme-ivy, Echinacea or cranberry.

Les infections respiratoires aiguës telles que la bronchite ou la sinusite et l'infection urinaire basse sont des motifs de consultation fréquents au cabinet du médecin de famille. Bronchites et sinusites sont pour la plupart d'origine virale et les antibiotiques n'ont que rarement leur place dans la prise en charge, alors que les infections urinaires requièrent le plus souvent la prescription d'antibiotiques. Dans les deux situations, les patients sont souvent demandeurs de médecine complémentaire pour soulager les symptômes ou prévenir les récidives. Cet article a pour but d'offrir une synthèse des données disponibles concernant l'efficacité et la sécurité de quelques traitements de médecine complémentaire utilisés dans ces indications, tels que le géranium rose, le mélange thym-primevère ou lierre, l'échinacée ou encore la canneberge.

[From theory to practice†: innovations in the family medicine curriculum in Swiss French-speaking universities]. / De la théorie à la pratique†:comment influencer le choix de carrière pour la médecine de famille†?

Family medicine is now an integral part of the curriculum of medical schools in Switzerland. The current challenge is to convey information about the attractive aspects of family medicine to medical students to address the growing shortage of primary care physicians. This article describes the implementation of a research program to promote career choice in family medicine, which leads to the development of a conceptual framework as a theoretical basis for teaching and research. Innovations from three medical schools in French-speaking Switzerland are presented. The authors describe the implication for family physicians in private practice, who are key partners of academic family medicine.

L'enseignement de la médecine de famille fait désormais partie intégrante du curriculum d'enseignement des facultés de médecine en Suisse. Le défi actuel est de mettre en valeur les aspects attractifs de cette discipline afin d'assurer la relève. Cet article décrit la mise en place d'un programme de recherche visant à promouvoir le choix de carrière en médecine de famille, aboutissant à des connaissances et à un cadre conceptuel comme base théorique pour le développement de l'enseignement en médecine de famille. Des innovations pédagogiques de trois facultés en Suisse romande sont présentées. Les auteurs décrivent les implications pour les médecins de famille pratiquant en cabinet, qui sont les partenaires incontournables de la médecine de famille académique.

[Opioid consumption from 1985 to 2015 : The situation in Switzerland, with an international comparison]. / Consommation d'opioïdes entre 1985 et 2015 : chiffres suisses et mise en perspective internationale.

In North America the massive increase in opioid prescriptions for chronic non-cancer pain has been a major health issue for several years. In Switzerland, the situation is less well known. This article aims to present the evolution of the Swiss consumption and replace it in a European and international context using the International Narcotics Control Board database. Between 1985 and 2015, the Swiss opioid consumption raised from 18 to 421 mg/person/year, making Switzerland the 7th largest opioid consumer per capita in the world. This increase could be due to more adequate pain management or liberalized opioid prescription for indications unsupported by the current evidence. Given these elements, further research is needed, yet increased caution is recommended when prescribing opioid drugs.

En Amérique du Nord, la large prescription d'opioïdes dans le cadre de douleurs chroniques non cancéreuses constitue une problématique majeure de santé publique depuis plusieurs années. La situation en Suisse est moins connue. Cet article vise à présenter l'évolution de la consommation suisse et de la replacer dans un contexte européen et international, en utilisant les données de l'International Narcotics Control Board. La Suisse est le 7e consommateur mondial d'opioïdes par habitant. Entre 1985 et 2015, la consommation suisse d'opioïdes forts est passée de 18 à 421 mg/habitant/année. Cette augmentation pourrait être due à une meilleure prise en charge de la douleur, mais aussi à une prescription plus libérale d'opioïdes pour des indications non démontrées. Ainsi, davantage de recherche est nécessaire, et en parallèle une prudence accrue est recommandée aux praticiens lors de la prescription d'opioïdes.

Complementary medicine use among general internal medicine inpatients in a Swiss university hospital.

BACKGROUND: Complementary Medicine (CM) is frequently used by the general population, but data about prevalence among hospitalised patients are scarce. We evaluated the prevalence and determinants of CM use by inpatients, lifetime, 2 months before and during their hospitalisation in a general internal medicine ward. METHODS: Cross-sectional survey conducted in September 2014 among adult (≥18 years) patients hospitalised for at least 1 day in the general internal medicine ward of the Lausanne University Hospital, Switzerland. The association between the socio-demographic data and CM used were assessed using logistic regression model. RESULTS: Among the 289 eligible patients, 130 (45%, mean age 68.9±16.4 years, 59.2% male) were included. The lifetime prevalence of CM use was 74.6%. One-third (31.5%) and one-tenth of patients reported CM use 2 months prior or during hospitalisation, respectively. The four most reported CM used during lifetime were homeopathy (54.6%), herbal medicine (49.5%), therapeutic massage (47.4%), and osteopathy (44.3%). Herbal medicine, homeopathy, meditation and therapeutic massage were the four main CM used during hospitalisation. On bivariate analysis, lifetime use of CM was significantly associated with higher level of education (apprenticeship: OR 3.2, 95% CI [1.20-8.51], high school/university: OR 7.67, 95% CI [2.59-22.70]; P=.004) and healthcare coverage for CM (OR 3.53, 95% CI [1.32-9.46]; P=.014), but not with age and gender. During hospitalisation only 3.8% of patients were asked about CM use by physicians. CONCLUSION: One-third of hospitalised patients used CM 2 months before hospitalisation and one-tenth during hospital stay. CM use is seldom queried by hospital staff; better assessment of CM use among hospitalised patients could prevent potential adverse events or interactions.

Agenda Setting During Follow-Up Encounters in a University Primary Care Outpatient Clinic.

At the beginning of the medical encounter, clinicians should elicit patients' agendas several times using open-ended questions. Little is known, however, about how many times physicians really solicit a patient's agenda during follow-up encounters. The objective was to analyze the number of agenda solicitations by physicians, of agendas initiated by physicians, and of patients' spontaneous agendas during the beginning and the entire encounter. We analyzed 68 videotaped follow-up encounters at a university primary care outpatient clinic. The number of different types of agenda setting was searched for and analyzed using negative binomial regression or logistic regression models. Physicians solicited agendas a mean ± SD of 0.8 ± 0.7 times/patient during the first 5 minutes and 1.7 ± 1.2 times/patient during the entire encounter. Physicians in 32.4% of encounters did not solicit the patient agenda, and there were never more than two physician's solicitations during the first 5 minutes. The mean number of physician's solicitations of the patients' agenda was 42% lower among female physicians during the first 5 minutes and 34% lower during the entire encounter. The number of agendas initiated by physicians was 1.2 ± 1.2/patient during the beginning and 3.2 ± 2.3/patient during the entire encounter. In 58.8% of the encounters, patients communicated their agendas spontaneously. There were twice as many patient spontaneous agendas (IRR = 2.12, p = .002) with female physicians than with males. This study showed that agenda solicitation with open-ended questions in follow-up encounters does not occur as often as recommended. There is thus a risk of missing new agendas or agendas that are important to the patient.

Chronic low back pain patients' use of, level of knowledge of and perceived benefits of complementary medicine: a cross-sectional study at an academic pain center.

BACKGROUND: Chronic pain patients often use complementary medicine (CM) to alleviate their pain; however, little is known about the use of CM by chronic low back pain (cLBP) patients. We investigated the frequency of use of CM by cLBP patients, the perceived effects of these therapies, patients' knowledge regarding CM, and patient-physician communication regarding CM. METHOD: A cross-sectional survey was conducted from November 2014 to February 2015. A questionnaire was distributed by physicians to 238 consecutive patients consulting for cLBP at the Pain Center of Lausanne University Hospital, Switzerland. Poisson regression model was used to analyze patients' level of knowledge regarding various CMs, and the logistic regression model was used to assess CM use for cLBP. RESULTS: The questionnaire was returned by 168 cLBP patients (response rate: 70.6%). Lifetime prevalence of CM use for cLBP was 77.3%. The most commonly used therapies were osteopathy (48.8%), massage (45.2%) and acupuncture (31.6%), rated for their usefulness on a 0-10 scale as a mean ± SD of 5.4 ± 2.7, 5.9 ± 2.5 and 3.8 ± 3.2, respectively. The CM treatment best known by patients was osteopathy, followed by massage and acupuncture. If their doctors proposed CM as a treatment for cLBP, 78% of participants reported being very or somewhat likely to try CM. Respondents with CM health insurance were more likely to use CM (OR = 2.26; 95%CI: 1.07-4.78; p = 0.031) for cLBP. Respondents having experienced cLBP for more than five years were more likely to use CM to treat their cLBP than respondents having experienced cLBP for one year or less (OR = 2.84; 95%CI: 1.02-7.88; p = 0.044). CONCLUSIONS: More than three-quarters of cLBP patients in our sample did use CM to treat their cLBP. The results showed that the most commonly used therapies were not necessarily the highest rated in terms of perceived usefulness. These results highlight the importance of developing integrative pain centers in which patients may obtain advice regarding CM treatments.

[Complementary medicine for low back pain : what is the scientific evidence ?] / Médecines complémentaires et lombalgies : que dit la littérature scientifique ?

Complementary medicines are frequently used by chronic pain patients. It is a challenge for the primary care physician to provide objective information based on the scientific literature. Meta-analyses have shown favourable effects of acupuncture, therapeutic massage and osteopathy for patients with acute low back pain. Concerning chronic low back pain, meta-analyses have shown positive results with acupuncture, osteopathy, yoga and tai-chi. Other therapies have shown positive effects, but further trials are necessary to fully validate them. This article reviews the literature supporting the most studied complementary medicines.

Les patients souffrant de douleurs chroniques sont souvent demandeurs de médecines complémentaires. C'est un défi pour le médecin de famille de les informer de façon objective, en se basant sur les données de la littérature scientifique. Actuellement, des méta-analyses montrent un effet favorable de l'acupuncture, du massage thérapeutique et de l'ostéopathie pour les lombalgies aiguës. Pour ce qui est des lombalgies chroniques, des méta-analyses ont montré un effet bénéfique de l'acupuncture, de l'ostéopathie, du yoga et du tai-chi. D'autres thérapies semblent bénéfiques, mais demandent encore à être validées. Cet article revoit l'évidence soutenant les médecines complémentaires les mieux étudiées.

[Is it possible to decrease cholesterol levels with dietary supplements?]. / Peut-on abaisser son taux de cholestérol avec des compléments alimentaires?

Patients often use dietary supplements for cardiovascular prevention. An US study showed that 75% of patients with cardiovascular disease used dietary supplements. Red yeast rice, phytosterols and fibers can significantly decrease LDL. The level of monacolin in red yeast rice can vary between products and toxins can sometimes be found. Prospective studies showed that fibers could decrease cardiovascular risk. Others substances, like guggul, soy and artichoke leaf extracts, did not show a clear benefit for cardiovascular prevention. Measurements of cholesterol levels can help the physician to discuss with his patient about the effects of some dietary supplements.

Centre de santé de soins primaires : à quoi ressemblera-t-il dans le futur ?

Poussé par les besoins croissants des patient·e·s et l'augmentation des différents professionnel·le·s de la santé, le lieu de travail du monde ambulatoire doit évoluer. La pandémie a montré que la digitalisation des pratiques, avec toutes les questions que cette transformation soulève, est l'un des aspects du futur qui s'ouvre. Mais elle n'est de loin pas le seul enjeu du centre de santé de demain. Prévention et promotion de la santé, santé intégrative, social, économie, architecture, durabilité : les défis sont multiples. Pour les matérialiser, la Revue Médicale Suisse, en partenariat avec Unisanté, organise un concours avec une vingtaine de jeunes médecins et professionnel·le·s de la santé entourés de douze tuteur·trice·s pour imaginer le centre de santé de demain. Le résultat sera présenté dans un show-room de 200 m2 aux Assises de la médecine romande le 4 novembre 2021.

A qualitative study of adolescents with medically unexplained symptoms and their parents. Part 1: Experiences and impact on daily life.

Medically unexplained symptoms (MUS) are common among adolescents and are frequently encountered in primary care. Our aim was to explore how these adolescents and their parents experience the condition and its impact on their daily lives and to provide recommendations for health professionals. Using a qualitative approach, six focus groups and two individual interviews were conducted. These involved a total of ten adolescents with different types of MUS and sixteen parents. The respondents were recruited in a university hospital in Switzerland. A thematic analysis was conducted according to the Grounded Theory. The analysis of the data highlighted four core themes: disbelief, being different, concealing symptoms, and priority to adolescent's health. Transcending these themes was a core issue regarding the discrepancy between the strategies that adolescents and their parents use to cope with the symptoms. Health professionals should be made aware of the emotional needs of these patients and their families.

The Significance of Traditional and Complementary Medicine to Self-Care and Addressing Global Health Challenges: Advancing the Commitments of the Declaration of Astana Through a Strong Research Program.

The Declaration of Astana (DoA) developed at the Global Conference on Primary Health Care (PHC) in 2018 outlined a number of core commitments and aspirations that fall in line with the broader vision for advancing global health, addressing a number of health-related sustainable development goals and ultimately ensuring health for all. Two specific goals of the DoA that are of particular interest and concern to the argument posited here are as follows: "to build sustainable primary health care" and "to empower individuals and communities." Moreover, these specific goals and the broader declaration all point to and "highlight the importance of empowering individuals as self-carers." However, it would appear that the conception of PHC, the related health workforce and the types of self-care activities, practices and initiatives envisioned within the DoA fail to explicitly accommodate or fully acknowledge the importance of both traditional and complementary medicine (T&CM) and more specifically "T&CM self-care" in strengthening the health of all communities. The aim of this editorial is to help articulate the significance of T&CM to self-care and as a consequence to the success of the DoA and wider desired advances in global health.