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1.
Lupus ; 29(1): 27-36, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31801040

RESUMO

BACKGROUND: Systemic lupus erythematosus (SLE) is regarded as a prototype autoimmune disease because it can serve as a means for studying differences between ethnic minorities and sex. Traditionally, all Hispanics have been bracketed within the same ethnic group, but there are differences between Hispanics from Spain and those from Latin America, not to mention other Spanish-speaking populations. OBJECTIVES: This study aimed to determine the demographic and clinical characteristics, severity, activity, damage, mortality and co-morbidity of SLE in Hispanics belonging to the two ethnic groups resident in Spain, and to identify any differences. METHODS: This was an observational, multi-centre, retrospective study. The demographic and clinical variables of patients with SLE from 45 rheumatology units were collected. The study was conducted in accordance with Good Clinical Practice guidelines. Hispanic patients from the registry were divided into two groups: Spaniards or European Caucasians (EC) and Latin American mestizos (LAM). Comparative univariate and multivariate statistical analyses were carried out. RESULTS: A total of 3490 SLE patients were included, 90% of whom were female; 3305 (92%) EC and 185 (5%) LAM. LAM patients experienced their first lupus symptoms four years earlier than EC patients and were diagnosed and included in the registry younger, and their SLE was of a shorter duration. The time in months from the first SLE symptoms to diagnosis was longer in EC patients, as were the follow-up periods. LAM patients exhibited higher prevalence rates of myositis, haemolytic anaemia and nephritis, but there were no differences in histological type or serositis. Anti-Sm, anti-Ro and anti-RNP antibodies were more frequently found in LAM patients. LAM patients also had higher levels of disease activity, severity and hospital admissions. However, there were no differences in damage index, mortality or co-morbidity index. In the multivariate analysis, after adjusting for confounders, in several models the odds ratio (95% confidence interval) for a Katz severity index >3 in LAM patients was 1.45 (1.038-2.026; p = 0.02). This difference did not extend to activity levels (i.e. SLEDAI >3; 0.98 (0.30-1.66)). CONCLUSION: SLE in Hispanic EC patients showed clinical differences compared to Hispanic LAM patients. The latter more frequently suffered nephritis and higher severity indices. This study shows that where lupus is concerned, not all Hispanics are equal.


Assuntos
Progressão da Doença , Lúpus Eritematoso Sistêmico/etnologia , Feminino , Humanos , América Latina/etnologia , Lúpus Eritematoso Sistêmico/fisiopatologia , Masculino , Sistema de Registros , Estudos Retrospectivos , Índice de Gravidade de Doença , Espanha/epidemiologia , População Branca/estatística & dados numéricos
2.
Am J Transplant ; 16(9): 2574-88, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-26932231

RESUMO

Fibrosis is a major component of chronic cardiac allograft rejection. Although several cell types are able to produce collagen, resident (donor-derived) fibroblasts are mainly responsible for excessive production of extracellular matrix proteins. It is currently unclear which cells regulate production of connective tissue elements in allograft fibrosis and how basophils, as potential producers of profibrotic cytokines, are involved this process. We studied this question in a fully MHC-mismatched model of heart transplantation with transient depletion of CD4(+) T cells to largely prevent acute rejection. The model is characterized by myocardial infiltration of leukocytes and development of interstitial fibrosis and allograft vasculopathy. Using depletion of basophils, IL-4-deficient recipients and IL-4 receptor-deficient grafts, we showed that basophils and IL-4 play crucial roles in activation of fibroblasts and development of fibrotic organ remodeling. In the absence of CD4(+) T cells, basophils are the predominant source of IL-4 in the graft and contribute to expansion of myofibroblasts, interstitial deposition of collagen and development of allograft vasculopathy. Our results indicated that basophils trigger the production of various connective tissue elements by myofibroblasts. Basophil-derived IL-4 may be an attractive target for treatment of chronic allograft rejection.


Assuntos
Basófilos/imunologia , Rejeição de Enxerto/etiologia , Cardiopatias/etiologia , Transplante de Coração/efeitos adversos , Interleucina-4/fisiologia , Aloenxertos , Animais , Feminino , Fibrose/etiologia , Fibrose/patologia , Rejeição de Enxerto/patologia , Sobrevivência de Enxerto , Cardiopatias/patologia , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Camundongos Knockout
3.
Rev Esp Quimioter ; 35 Suppl 1: 6-14, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35488817

RESUMO

Severe lower respiratory tract infection is a common issue in Intensive Care Units that causes significant morbidity and mortality. The traditional diagnostic-therapeutic approach has been grounded on taking respiratory samples and/or blood cultures as soon as possible and starting empirical antibiotic therapy addressed to cover most likely pathogens based on the presence of the patient's risk factors for certain microorganisms, while waiting for the culture results in the following 48-72 hours to adequate the antibiotic treatment to the sensitivity profile of the isolated pathogen. Unfortunately, this strategy leads to use broad-spectrum antibiotics more times than necessary and does not prevent possible therapeutic failures. The recent development of rapid molecular diagnostic techniques, based on real time polymerase chain reaction (RT-PCR), makes it possible to determine the causative agent and its main resistance pattern between 1 and 5 hours after sampling (depending on each tecnique), with high precision, some of them reaching a negative predictive value greater than 98%, facilitating the very early withdrawal of unnecessary broad-spectrum antibiotics. Its high sensitivity can also detect unsuspected pathogens based on risk factors, allowing adequate treatment in the first hours of stay. This short review discusses the potential usefulness of these techniques in critically ill patients with lower respiratory tract infection and advocates their immediate implementation in clinical practice.


Assuntos
Estado Terminal , Pneumonia , Antibacterianos/uso terapêutico , Humanos , Unidades de Terapia Intensiva , Pneumonia/tratamento farmacológico
4.
Clin Exp Rheumatol ; 27(6): 920-5, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20149306

RESUMO

OBJECTIVES: The morbidity and mortality of patients with rheumatic diseases has improved considerably following the use of biologic therapies. However, an increase in the frequency of bacterial infections has been observed in patients receiving these drugs. In the present study we aimed to establish the incidence and clinical manifestations of non-typhi Salmonella infection in a large cohort of patients with rheumatic diseases undergoing TNF-alpha antagonist therapy due to severe rheumatic diseases refractory to conventional therapies. METHODS: The rate of non-typhi Salmonella infection found in the Spanish Registry of Adverse Events of Biological Therapies in Rheumatic Diseases (BIOBADASER) was compared with that observed in a cohort of rheumatoid arthritis (RA) patients from the EMECAR (Morbidity and Clinical Expression of Rheumatoid Arthritis) Study, who were not treated with TNF-alpha antagonists. The rate found in the BIOBADASER registry was also compared with that available in a non-RA historic control cohort reported in a population from Huesca (Northern Spain). RESULTS: Seventeen cases of non-typhi Salmonella infection were observed in the series of patients exposed to anti-TNF-alpha therapies. The incidence rate of non-typhi Salmonella in BIOBADASER was 0.73 per 1000 patient-years (95% confidence interval [CI]: 0.45-1.17). The incidence rate in the EMECAR cohort was 0.44 per 1000 patient-years. The relative risk for non-typhi salmonellosis in RA patients exposed to TNF-alpha inhibitors compared to those not treated with biological therapies was 2.07 (95% CI: 0.27-15.73) (p=0.480) whereas the relative risk of non-typhi Salmonella infections in patients with rheumatic diseases undergoing TNF-alpha antagonist therapy compared with the non-RA Spanish control cohort was 0.63 (95% CI: 0.38-1.04) (p=0.07). Nine of the 17 patients with non-typhi salmonellosis presented a severe systemic infection. CONCLUSION: Incidence of non-typhi Salmonella infection is not increased significantly in rheumatic patients undergoing anti-TNF-alpha therapy when compared with RA patients undergoing conventional DMARD therapy or with the general population. Nevertheless, at least 50% of patients on TNF-alpha have severe complications once they develop non-typhi Salmonella infection. This fact suggests that anti-TNF-alpha therapies may predispose to salmonella dissemination rather than to infection.


Assuntos
Anticorpos Monoclonais/uso terapêutico , Doenças Reumáticas/epidemiologia , Infecções por Salmonella/epidemiologia , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Adulto , Idoso , Anticorpos Monoclonais/efeitos adversos , Antirreumáticos/efeitos adversos , Antirreumáticos/uso terapêutico , Feminino , Humanos , Imunoterapia , Incidência , Masculino , Pessoa de Meia-Idade , Sistema de Registros , Doenças Reumáticas/complicações , Doenças Reumáticas/terapia , Infecções por Salmonella/complicações , Espanha/epidemiologia , Fator de Necrose Tumoral alfa/uso terapêutico
6.
Br J Pharmacol ; 153(8): 1750-61, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18311191

RESUMO

BACKGROUND AND PURPOSE: Flavonoids are known to possess a broad set of pharmacological effects, some of which have been attributed to their antioxidant properties and, more recently, to cell signalling modulation. Nevertheless, flavonoids are extensively metabolized and their metabolites are the potential bioactive forms in vivo. Therefore, a first and crucial step to understand the mechanisms underlying potential health benefits of flavonoids is knowledge of their metabolites and their biological activities. EXPERIMENTAL APPROACH: To approximate a human dietary pattern of intake of flavonoids, regular rat chow was supplemented with 0.02% quercetin and fed to Sprague-Dawley rats over 3 weeks. Plasma samples were analysed by HPLC and electrospray tandem mass spectrometry, and plasma antioxidant capacity was measured by the 2,2'-azino-bis(3-ethylbenzothiazoline sulphonate) assay. KEY RESULTS: Major metabolites were 3'-methylquercetin (isorhamnetin) glucuronide sulphate conjugates, the most plausible conjugation positions being at the 3-, 5- and 7-hydroxyl positions. Isorhamnetin conjugates are methylated at the 3'-OH position, which decreases the high antioxidant activity of quercetin and its metabolites and their contribution to plasma antioxidant potential. CONCLUSIONS AND IMPLICATIONS: This metabolic pattern differs from that observed after a single high-dose administration, where the major metabolites were quercetin conjugates at 5- and 7-hydroxyl positions and a significantly increased plasma antioxidant activity was observed. These data show altogether that the different metabolic patterns obtained under a prolonged low-dosage regimen or after a single high dose, crucially affected the antioxidant potential of plasma in treated animals. Our data also allow for the establishment of structure-antioxidant activity relationships for quercetin metabolites.


Assuntos
Antioxidantes/farmacocinética , Quercetina/farmacocinética , Animais , Antioxidantes/administração & dosagem , Benzotiazóis , Cromatografia Líquida de Alta Pressão , Glucuronídeos , Masculino , Metilação , Quercetina/administração & dosagem , Ratos , Ratos Sprague-Dawley , Espectrometria de Massas por Ionização por Electrospray , Sulfatos , Ácidos Sulfônicos/metabolismo , Tiazóis/metabolismo
9.
Clin Exp Rheumatol ; 22(4): 465-8, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15301245

RESUMO

OBJECTIVE: To assess the prevalence of HLA-B27 and its subtypes in both the normal population and in patients with Ankylosing Spondylitis (AS) in Galicia, Northwest Spain. METHODS: The prevalence of HLA-B27 in the normal population was determined by checking the number of HLA-B27 positive samples in 308 subjects from different areas of Galicia who had donated organs over a period of 4 years. A total of 106 patients with the diagnosis of AS, according to the modified New York clinical criteria for definitive ankylosing spondylitis, were collected from three very representative areas of Galicia. HLA-B27 was determined by PCR using the primers E91s and E136as, while 11 subtypes of HLA-B27 were analyzed using a commercial kit. RESULTS: The prevalence of HLA-B27 in organ donors was 9.34%. HLA-B27 was present in 94.3% of patients with AS. Subtypes B*2701, B*2709 and B*2710 were not found. The subtypes found in the normal population were; B*2705 (79.5%), B*2702 (18%) and B*2708 (2.5%). The subtypes associated with AS were B*2705 (88%) and B*2702 (12%). CONCLUSION: The prevalence of HLA-B27 in Galicia was 9.34%, which is higher than previously published in Spain. The frequency of the subtypes associated with AS was similar to that reported for other Spanish regions.


Assuntos
Predisposição Genética para Doença , Antígeno HLA-B27/genética , Espondilite Anquilosante/genética , DNA/análise , Antígeno HLA-B27/sangue , Antígeno HLA-B27/classificação , Humanos , Reação em Cadeia da Polimerase , Prevalência , Estudos Retrospectivos , Espanha/epidemiologia , Espondilite Anquilosante/sangue , Espondilite Anquilosante/epidemiologia
10.
Clin Exp Rheumatol ; 20(3): 327-33, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12102468

RESUMO

OBJECTIVES: To study the epidemiology, clinical features, and outcome of non-human immunodeficiency virus (HIV) patients diagnosed with tuberculous spondylitis (TS) in a well-defined region of northwestern Spain. METHODS: Retrospective chart review of patients older than 14 years of age diagnosed with TS at two contiguous areas between 1986 and 1999. RESULTS: Thirty-seven patients (19 men; mean age 60.3 years) were diagnosed with TS. The average annual incidence rate of TS was 0.55/100,000 population 15 years of age and older. The thoracic and lumbar regions were affected in most cases. The mean duration of symptoms before diagnosis was 28 weeks (range 3-129). Active or healed pulmonary tuberculosis was observed in only 30%. The tuberculin skin test was negative in 24%. The most common findings at the time of diagnosis were back pain and elevated ESR (either 89%). Of note, only 19% had fever. On admission plain radiographs disclosed the presence of spondylitis in 84% of the patients. Computed tomography scan and magnetic resonance imaging yielded conclusive diagnostic data in the cases with normal radiographs, and were very useful in the visualization of abscesses and intraspinal compression. Cultures of material from percutaneous needle aspiration and open bone biopsy were positive for Mycobacterium tuberculosis in 79% and 77% of the cases, respectively. Antituberculous therapy was given to all patients (mean duration of treatment 44 weeks). Surgical procedures were performed in 12 cases, in 7 of them to remove paraspinal and/or epidural abscesses, and in 5 because of neurological complications. Local pain and neurological deficits were the mostfrequent sequelae (16 and 8 cases, respectively). One patient died during the course of treatment due to a co-morbid disease. None of the patients had relapses of tuberculosis. CONCLUSION: TS is a major cause of morbidity. There is a long delay to the diagnosis in most patients. Awareness of its clinical features and early therapy are required to reduce severe complications.


Assuntos
Espondilite/epidemiologia , Tuberculose Osteoarticular/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Infecções por HIV , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Estudos Retrospectivos , Espanha/epidemiologia , Espondilite/diagnóstico por imagem , Espondilite/microbiologia , Espondilite/terapia , Resultado do Tratamento , Tuberculose Osteoarticular/diagnóstico por imagem
11.
J Pharm Biomed Anal ; 27(1-2): 81-90, 2002 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-11682213

RESUMO

The resolution of binary mixtures of triamterene (TAT) and leucovorin (LV) by application of first-derivative spectrophotometry and by application of Partial Least Squares calibration (PLS-1) was performed. Triamterene is determined in presence of leucovorin directly in the absorption spectra at 358 nm, and leucovorin is determined in the first-derivative spectra at 305.6 nm, zero-crossing of the triamterene. The mean recovery values in urine samples were 102 and 97% for TAT and LV, respectively. Partial Least Squares calibration (PLS-1) multivariate calibration of spectrophotometric data, have been applied to the determination of these compounds in serum and in urine without pretreatment of the samples. The absorption spectra of samples of serum or urine, spiked with triamterene and/or leucovorin, were used to perform the optimization of the calibration matrices by PLS-1 method. Mean recovery values were of 107 and 108% for TAT and LV in serum samples, and 98 and 91% for TAT and LV in urine samples.


Assuntos
Diuréticos/análise , Leucovorina/análise , Triantereno/análise , Calibragem , Diuréticos/sangue , Diuréticos/urina , Humanos , Leucovorina/sangue , Leucovorina/urina , Espectrofotometria Ultravioleta/métodos , Medicina Esportiva , Triantereno/sangue , Triantereno/urina
13.
Urologe A ; 37(1): 86-9, 1998 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-9540192

RESUMO

A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture. No vaccination was given to either patient. From a state of good health, both patients developed fulminant, therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture. Autopsy findings were similar to Water-house-Friderichsen-syndrome. In conjunction with the history of splenectomy, the final pathological diagnosis was a so-called OPSI syndrome. This postsplenectomy sepsis is discussed further.


Assuntos
Infecções Pneumocócicas/patologia , Complicações Pós-Operatórias/patologia , Choque Séptico/patologia , Esplenectomia , Ruptura Esplênica/cirurgia , Glândulas Suprarrenais/patologia , Adulto , Feminino , Humanos , Linfonodos/patologia , Masculino , Pessoa de Meia-Idade , Tonsila Palatina/patologia , Baço/patologia , Ruptura Esplênica/patologia , Síndrome de Waterhouse-Friderichsen/patologia
14.
An Med Interna ; 12(10): 492-4, 1995 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-8519939

RESUMO

We report a case of Temporal Arteritis, carrier of IgG anticardiolipin antibodies, who presented seronegative polyarthritis with AR criteria after 7 months. Three months later he developed acute ischemia in the right leg, which induced to amputate it. The biopsy showed thrombosis of the femoral arteria, and a dense lymphoplasmocytic infiltrate in its wall. We underline this association (TA-RA) with anticardiolipin antibodies, the exceptional affectation of the femoral arteries in this disease and the probable participation of anticardiolipin antibodies in the genesis of the arterial thrombosis.


Assuntos
Artrite Reumatoide/complicações , Arterite de Células Gigantes/complicações , Isquemia/etiologia , Perna (Membro)/irrigação sanguínea , Idoso , Anti-Inflamatórios/uso terapêutico , Anticorpos Anticardiolipina/sangue , Artrite Reumatoide/tratamento farmacológico , Artrite Reumatoide/imunologia , Cegueira/etiologia , Artéria Femoral , Arterite de Células Gigantes/tratamento farmacológico , Arterite de Células Gigantes/imunologia , Humanos , Masculino , Artéria Oftálmica , Prednisona/uso terapêutico
15.
An Med Interna ; 10(8): 395-7, 1993 Aug.
Artigo em Espanhol | MEDLINE | ID: mdl-8218786

RESUMO

Two patients diagnosed of seropositive Rheumatoid Arthritis, developed severe renal failure associated in one case to alveolar hemorrhage. The renal histological study showed in both patients Focal and Segmentary Necrotizing Glomerulonephritis, with extracapillary proliferation. There were no evidences of concomitant diseases or nephrotoxic pharmacological therapy in the two patients. The first patient had a positive response to the corticosteroid and immunosuppressive therapy, whereas the second patient developed an irreversible renal failure. We think that this complication, although extremely rare, must be taken into account in all patients with Rheumatoid Arthritis presenting a quick and sudden impairment of his renal function.


Assuntos
Artrite Reumatoide/complicações , Glomerulosclerose Segmentar e Focal/etiologia , Adulto , Glomerulosclerose Segmentar e Focal/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Necrose
17.
Anal Biochem ; 346(2): 201-9, 2005 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-16213456

RESUMO

A novel HPLC method, using UV and fluorimetric serial detection, for the simultaneous determination of methotrexate (MTX), five disease marker pteridines, and the reference metabolic subproduct creatinine (CREA) in human urine was established. A previous oxidation process using 10(-3) M KMnO4 (pH 5.0) and 35min of oxidation time was necessary to transform the analytes in the highly fluorescent pteridinic rings. CREA was not affected by the oxidative medium. Using Tris-HCl/NaCl buffer solution (pH 6.6) as mobile phase, MTX and the assayed pteridines were monitored by fluorescence at lambda(em) = 444 nm and lambda(ex) = 280 nm and creatinine was monitored by absorption measurements at lambda(abs) = 230 nm. All components were well resolved in approximately 7 min. Detection limits, according the criteria of Clayton and co-workers, were 10 ng ml(-1) for MTX, less than 1 ng ml(-1) for all of the pteridines, and 4 microg ml(-1) for CREA.


Assuntos
Cromatografia Líquida de Alta Pressão/métodos , Creatinina/urina , Metotrexato/urina , Pteridinas/urina , Biomarcadores/urina , Fluorometria , Humanos , Metotrexato/química , Oxirredução , Fotometria , Permanganato de Potássio/química , Pteridinas/química , Raios Ultravioleta
18.
Sangre (Barc) ; 38(6): 449-53, 1993 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-8171380

RESUMO

PURPOSE: To evaluate our experience in the treatment of disseminated intravascular coagulation (DIC) associated to AML-M3 with substitution therapy with or without heparin. PATIENTS AND METHODS: The clinical records of 19 patients diagnosed of AML-M3 in the Hospital Juan Canalejo, in La Coruña, between 1986 and 1991 were revised. DIC was defined by abnormalities in one or more of the following: prothrombin time, activated partial thromboplastic time, thrombin time, fibrinogenaemia, fibrin/fibrinogen degradation products, D-dimers. The treatment given to 13 patients was only substitutive including platelets, fresh-frozen plasma, cryoprecipitates and antithrombin III. Low-dose sodium heparin (Kabi) in continuous intravenous infusion was associated to the treatment of the remaining 6 patients. With regard to the leukaemic therapy, most of the patients received daunorubicin, 2 mg/kg/day x 5 days, and AraC, 100 mg/Kg/day x 7 days. RESULTS: All patients showed haemorrhagic symptoms at diagnosis, and laboratory data of DIC were present in 11 cases (57%). The mean duration of DIC was 6.5 days for the patients receiving substitutive treatment and 9.5 days for those given heparin. Complete remission (CR) of the leukaemia was attained in 12 cases (63%); of the patients treated with heparin, 50% achieved CR whereas 75% of those receiving substitute therapy attained CR. The 24-months survival rate was 30% for the patients treated with substitutive therapy and 16% for those treated with heparin. The incidence of death associated to haemorrhage during induction therapy was 30% for the substitutive treatment group and 50% for the heparin group. CONCLUSION: Shorter duration of DIC, lesser rate of early death, higher CR rate and longer 2-year survival were found in those AML-M3 patients not receiving heparin.


Assuntos
Coagulação Intravascular Disseminada/terapia , Leucemia Promielocítica Aguda/complicações , Adolescente , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Antitrombina III/uso terapêutico , Testes de Coagulação Sanguínea , Pré-Escolar , Terapia Combinada , Citarabina/administração & dosagem , Daunorrubicina/administração & dosagem , Coagulação Intravascular Disseminada/sangue , Coagulação Intravascular Disseminada/etiologia , Coagulação Intravascular Disseminada/mortalidade , Hemorragia/etiologia , Heparina/efeitos adversos , Heparina/uso terapêutico , Humanos , Leucemia Promielocítica Aguda/tratamento farmacológico , Leucemia Promielocítica Aguda/mortalidade , Pessoa de Meia-Idade , Mitoxantrona/administração & dosagem , Plasma , Transfusão de Plaquetas , Indução de Remissão , Resultado do Tratamento
19.
Pathologe ; 18(3): 257-60, 1997 May.
Artigo em Alemão | MEDLINE | ID: mdl-9273546

RESUMO

A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture. No vaccination was given to either patient. From a state of good health, both patients developed fulminant, therapy-resistant sepsis with proof of Streptococcus pneumonlae in the blood culture. Autopsy findings were similar to Waterhouse-Friderichsen-syndrome. In conjunction with the history of splenectomy, the final pathological diagnosis was a so-called OPSI syndrome. This postsplenectomy sepsis is discussed further.


Assuntos
Infecções Pneumocócicas/patologia , Choque Séptico/patologia , Esplenectomia , Ruptura Esplênica/cirurgia , Glândulas Suprarrenais/patologia , Diagnóstico Diferencial , Feminino , Centro Germinativo/patologia , Humanos , Fígado/patologia , Linfonodos/patologia , Pessoa de Meia-Idade , Necrose , Tonsila Palatina/patologia , Pele/patologia , Ruptura Esplênica/patologia , Síndrome de Waterhouse-Friderichsen/patologia
20.
Hum Genet ; 75(1): 56-61, 1987 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-3804333

RESUMO

The possible influence of total Y chromosome length and the C-band size variability of chromosomes 1, 9, 16, and Y, on reproductive wastage was investigated. One hundred couples with recurrent reproductive wastage and 106 control couples with at least two healthy children and no miscarriages were cytogenetically studied. Total Y chromosome length was evaluated as the Y/F index and the C-band size was analyzed quantitatively according to the linear measurement method of Balicek et al. (1977). The different degrees of mitotic contraction were corrected on the basis of the linear correlation found between heterochromatin and euchromatin length. Statistical comparison between results of Y chromosome from both samples demonstrated, in the test group, an increase in the mean value of the Y/F index, but the increase of Y C-band length did not reach significance. In addition mean values of C-band length on chromosomes 1, 9, and 16 in couples from the test group and especially those who had had two or more abortions, were lower than those in the controls. Among the latter the frequency of chromosomes included in the category of very large heterochromatin size is higher. However these length differences have been demonstrated only in specific subgroups, and in each one for a different chromosome. Our results indicated that Y chromosome length as well as C-band size variabilities are not directly related to reproductive wastage.


Assuntos
Aborto Espontâneo/genética , Variação Genética , Heterocromatina/genética , Bandeamento Cromossômico , Cromossomos Humanos Par 1 , Cromossomos Humanos Par 16 , Cromossomos Humanos Par 9 , Feminino , Humanos , Masculino , Gravidez , Cromossomo Y
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