Detalhe da pesquisa
1.
Perspective on high-throughput bioanalysis to support in vitro assays in early drug discovery.
Bioanalysis
; 15(3): 177-191, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36917553
2.
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs.
Bioorg Med Chem Lett
; 21(6): 1588-92, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21349711
3.
Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions.
J Med Chem
; 63(23): 14867-14884, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33201708
4.
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4).
ACS Med Chem Lett
; 10(8): 1228-1233, 2019 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31413810
5.
Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).
J Med Chem
; 62(20): 9270-9280, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31532662
6.
Development of potent and selective small-molecule human Urotensin-II antagonists.
Bioorg Med Chem Lett
; 18(12): 3500-3, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18502123
7.
Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles.
Bioorg Med Chem Lett
; 18(13): 3716-9, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18524591
8.
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.
J Med Chem
; 61(24): 11209-11220, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30500190
9.
Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4.
ACS Med Chem Lett
; 8(5): 549-554, 2017 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28523109
10.
Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors.
J Med Chem
; 49(5): 1597-612, 2006 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16509577
11.
Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema.
ACS Med Chem Lett
; 4(2): 293-6, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900661
12.
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.
Sci Transl Med
; 4(159): 159ra148, 2012 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23136043
13.
Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor.
Bioorg Med Chem Lett
; 17(6): 1713-7, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17236763