Detalhe da pesquisa
1.
The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.
Annu Rev Biochem
; 92: 273-298, 2023 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37001135
2.
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Cell
; 168(1-2): 264-279.e15, 2017 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28086093
3.
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Cell
; 178(1): 261, 2019 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31251914
4.
A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells.
Proc Natl Acad Sci U S A
; 121(7): e2318024121, 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38330014
5.
Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.
Development
; 148(19)2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34486668
6.
TDP-43 α-helical structure tunes liquid-liquid phase separation and function.
Proc Natl Acad Sci U S A
; 117(11): 5883-5894, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32132204
7.
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
EMBO J
; 37(5)2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29438978
8.
Biochemical mechanisms of vertebrate hedgehog signaling.
Development
; 146(10)2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092502
9.
Cholesterol access in cellular membranes controls Hedgehog signaling.
Nat Chem Biol
; 16(12): 1303-1313, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33199907
10.
Lipid droplets can promote drug accumulation and activation.
Nat Chem Biol
; 16(2): 206-213, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932720
11.
Structural basis of Smoothened regulation by its extracellular domains.
Nature
; 535(7613): 517-522, 2016 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437577
12.
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat Chem Biol
; 15(10): 975-982, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548691
13.
An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.
EMBO Rep
; 17(5): 739-52, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27113758
14.
An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.
EMBO Rep
; 22(5): e52895, 2021 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33949092
15.
Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.
PLoS Genet
; 11(8): e1005473, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26291458
16.
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.
Genes Dev
; 24(7): 670-82, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20360384
17.
G-protein-coupled receptors, Hedgehog signaling and primary cilia.
Semin Cell Dev Biol
; 33: 63-72, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24845016
18.
Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.
J Biol Chem
; 289(16): 11095-11110, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24596093
19.
Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier.
Nat Chem Biol
; 9(7): 437-43, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23666116
20.
Oxysterols are allosteric activators of the oncoprotein Smoothened.
Nat Chem Biol
; 8(2): 211-20, 2012 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22231273