Detalhe da pesquisa
1.
Translation of nonclinical to clinical safety findings for 27 biotherapeutics.
Toxicol Appl Pharmacol
; 484: 116854, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346540
2.
Inflammatory Cell Findings in the Female Rabbit Heart and Stress-associated Exacerbation with Handling and Procedures Used in Nonclinical Studies.
Toxicol Pathol
; 45(3): 416-426, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28349785
3.
Mechanistic investigations of test article-induced pancreatic toxicity at the endocrine-exocrine interface in the rat.
Toxicol Pathol
; 42(1): 229-42, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24226507
4.
Discovery and development of COVID-19 vaccines and therapeutics: nonclinical perspectives.
J Toxicol Sci
; 49(3): 79-94, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38432955
5.
"Candidatus Mycoplasma haemomacaque" and Bartonella quintana bacteremia in cynomolgus monkeys.
J Clin Microbiol
; 51(5): 1408-11, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23408694
6.
Toxicological Assessments of a Pandemic COVID-19 Vaccine-Demonstrating the Suitability of a Platform Approach for mRNA Vaccines.
Vaccines (Basel)
; 11(2)2023 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36851293
7.
COVID-19 Therapeutics and Vaccines: A Race to Save Lives.
Toxicol Sci
; 185(2): 119-127, 2022 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34735018
8.
Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine.
Reprod Toxicol
; 103: 28-35, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34058573
9.
Maternal immunization with Group B Streptococcus six-valent polysaccharide conjugate vaccine supported by lack of toxicity in rat and rabbit fertility and developmental toxicity studies.
Birth Defects Res
; 113(19): 1343-1356, 2021 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516044
10.
Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies.
Anal Chem
; 82(12): 5282-9, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20469835
11.
PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers.
Mol Cancer Ther
; 19(10): 2068-2078, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32747418
12.
A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.
Clin Cancer Res
; 26(9): 2188-2202, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31996389
13.
The use of probiotics in the prevention and treatment of antibiotic-associated diarrhea with special interest in Clostridium difficile-associated diarrhea.
Nutr Clin Pract
; 24(1): 33-40, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19244146
14.
Agonistic TAM-163 antibody targeting tyrosine kinase receptor-B: applying mechanistic modeling to enable preclinical to clinical translation and guide clinical trial design.
MAbs
; 5(3): 373-83, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23529133
15.
Activation of TrkB with TAM-163 results in opposite effects on body weight in rodents and non-human primates.
PLoS One
; 8(5): e62616, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23700410
16.
Metabonomic evaluation of metabolic dysregulation in rats induced by PF 376304, a novel inhibitor of phosphoinositide 3-kinase.
Chem Res Toxicol
; 20(12): 1871-7, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18001061
17.
Metabonomic evaluation of Schaedler altered microflora rats.
Chem Res Toxicol
; 20(10): 1388-92, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17900170
18.
All-trans retinoic acid antagonizes the action of calciferol and its active metabolite, 1,25-dihydroxycholecalciferol, in rats.
J Nutr
; 135(7): 1647-52, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15987844
19.
Bone resorption activity of all-trans retinoic acid is independent of vitamin D in rats.
J Nutr
; 133(3): 777-83, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12612152
20.
A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation.
J Biol Chem
; 279(42): 43448-61, 2004 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15297464