Detalhe da pesquisa
1.
Shifting landscapes of human MTHFR missense-variant effects.
Am J Hum Genet
; 108(7): 1283-1300, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34214447
2.
Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation.
Mol Hum Reprod
; 30(4)2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38366926
3.
Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.
Hum Mol Genet
; 27(7): 1123-1135, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29360980
4.
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.
Hum Mol Genet
; 26(5): 888-900, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28069796
5.
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
J Nutr
; 148(4): 501-509, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29659962
6.
Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.
Mol Carcinog
; 56(3): 1030-1040, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27597531
7.
Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5'-end methylation.
Mamm Genome
; 27(3-4): 122-34, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951114
8.
Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.
Exp Eye Res
; 145: 164-172, 2016 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26646559
9.
MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice.
Birth Defects Res A Clin Mol Teratol
; 103(12): 1031-8, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26408344
10.
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Biochem J
; 461(2): 205-12, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24800750
11.
Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.
Proteomics
; 14(21-22): 2558-65, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25081070
12.
Increased resistance to malaria in mice with methylenetetrahydrofolate reductase (Mthfr) deficiency suggests a mechanism for selection of the MTHFR 677C>T (c.665C>T) variant.
Hum Mutat
; 35(5): 594-600, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616178
13.
The MTHFD1 1958G>A variant is associated with elevated C-reactive protein and body mass index in Canadian women from a premature birth cohort.
Mol Genet Metab
; 111(3): 390-392, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24368157
14.
Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.
Mol Nutr Food Res
; 68(5): e2300355, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38327171
15.
Moderately high intake of folic acid has a negative impact on mouse embryonic development.
Birth Defects Res A Clin Mol Teratol
; 97(1): 47-52, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23125102
16.
Risk of congenital heart defects is influenced by genetic variation in folate metabolism.
Cardiol Young
; 23(1): 89-98, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22475273
17.
Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.
Mol Genet Metab
; 106(2): 149-59, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22521626
18.
Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARα, interferon-γ, and interleukin-10.
J Nutr
; 142(3): 411-8, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22259189
19.
DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.
Genome
; 55(9): 673-82, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22967183
20.
Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Sex-Specific Gene Expression in Brain of Young Mice and Embryos.
Nutrients
; 14(5)2022 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35268026