RESUMO
OBJECTIVE: This systematic review aimed to investigate the role of the C-X3-C motif ligand 1/chemokine receptor 1 C-X3-C motif (CX3CL1/CX3CR1) axis in the pathogenesis of periodontitis. Furthermore, as a secondary objective, we determine whether the CX3CL1/CX3CR1 axis could be considered complementary to clinical parameters to distinguish between periodontitis and rheumatoid arthritis (RA) and/or systemically healthy subjects. METHODS: The protocol used for this review was registered in OSF (10.17605/OSF.IO/KU8FJ). This study was designed following Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Records were identified using different search engines (PubMed/MEDLINE, Scopus, Science Direct, and Web of Science) from August 10, 2006, to September 15, 2023. The observational studies on human subjects diagnosed with periodontitis and RA and/or systemically healthy were selected to analyze CX3CL1 and CX3CR1 biomarkers. The methodological validity of the selected articles was assessed using NIH. RESULTS: Six articles were included. Biological samples (gingival crevicular fluid [GCF], saliva, gingival tissue biopsies, serum) from 379 subjects (n = 275 exposure group and n = 104 control group) were analyzed. Higher CX3CL1 and CX3CR1 chemokine levels were found in subjects with periodontitis and RA compared with periodontal and systemically healthy subjects. CONCLUSION: Very few studies highlight the role of the CX3CL1/CX3CR1 axis in the pathogenesis of periodontitis; however, increased levels of these chemokines are observed in different biological samples (GCF, gingival tissue, saliva, and serum) from subjects with periodontitis and RA compared with their healthy controls. Future studies should focus on long-term follow-up of subjects and monitoring changes in cytokine levels before and after periodontal therapy to deduce an appropriate interval in health and disease conditions.
Assuntos
Artrite Reumatoide , Periodontite , Humanos , Artrite Reumatoide/diagnóstico , Citocinas , Biomarcadores , Biópsia , Quimiocinas CC , Receptor 1 de Quimiocina CX3C , Quimiocina CX3CL1RESUMO
La funduplicación de Nissen es una de las operaciones para reflujo gastroesofágico de mayor aceptación; sin embargo, es una operación con importante morbilidad para una patología benigna. Esta operación, se ha venido haciendo en los últimos años mediante cirugía laparoscópica con menores problemas que la cirugía clásica abierta. Presentamos una experiencia preliminar de 44 casos resueltos con este abordaje en el que tenemos un 94.8 por ciento de pacientes con alivio de los síntomas y mínimas complicaciones. Solo 2 pacientes requirieron una segunda cirugía. La presión final del esfinter fue de 25 mmH y la longitud de la funduplicatura fue de 3.06 cms