Intrinsic capacity trajectories and socioeconomic inequalities in health: the contributions of wealth, education, gender, and ethnicity.

BACKGROUND: Life-long health inequalities exert enduring impacts and are governed by social determinants crucial for achieving healthy aging. A fundamental aspect of healthy aging, intrinsic capacity, is the primary focus of this study. Our objective is to evaluate the social inequalities connected with the trajectories of intrinsic capacity, shedding light on the impacts of socioeconomic position, gender, and ethnicity. METHODS: Our dynamic cohort study was rooted in three waves (2009, 2014, 2017) of the World Health Organization's Study on Global AGEing and Adult Health in Mexico. We incorporated a nationally representative sample comprising 2722 older Mexican adults aged 50 years and over. Baseline measurements of socioeconomic position, gender, and ethnicity acted as the exposure variables. We evaluated intrinsic capacity across five domains: cognition, psychological, sensory, vitality, and locomotion. The Relative Index of Inequality and Slope Index of Inequality were used to quantify socioeconomic disparities. RESULTS: We discerned three distinct intrinsic capacity trajectories: steep decline, moderate decline, and slight increase. Significant disparities based on wealth, educational level, gender, and ethnicity were observed. Older adults with higher wealth and education typically exhibited a trajectory of moderate decrease or slight increase in intrinsic capacity. In stark contrast, women and indigenous individuals were more likely to experience a steeply declining trajectory. CONCLUSIONS: These findings underscore the pressing need to address social determinants, minimize gender and ethnic discrimination to ensure equal access to resources and opportunities across the lifespan. It is imperative for policies and interventions to prioritize these social determinants in order to promote healthy aging and alleviate health disparities. This approach will ensure that specific demographic groups receive customized support to sustain their intrinsic capacity during their elder years.

Prospective changes in anemia are associated with the incidence and persistence of sarcopenia among older Mexican adults.

Background: Low hemoglobin levels are a significant biomarker in the prognosis of sarcopenia. Anemia and sarcopenia are frequent and disabling conditions in the older adult population, but little is known about the role of anemia in the onset and progression of sarcopenia. This study aimed to determine whether prospective changes in anemia are associated with the incidence and persistence of sarcopenia. Methods: Data come from the second and third waves (2014, 2017) of the World Health Organization (WHO) Study on global AGEing and adult health (SAGE) in Mexico. SAGE-Mexico is a dynamic cohort with national representativeness, including a follow-up sample and new enrollments. For this study, 1,500 older adults (aged 50 or above) with measurements in both waves were included. Sarcopenia was defined as having low muscle quantity and either/both slow gait speed and weak handgrip strength. Anemia was defined according to hemoglobin concentrations, adjusted for altitude, as recommended by the WHO, <120 g/L for women and <130 g/L for men. Multinomial logistic regression was used to estimate the association between anemia and prospective changes in sarcopenia. Results: The baseline prevalence of anemia was 17.4%, and that of sarcopenia was 12.1%. The incidence and persistence of anemia were 10.6% (95% CI: 7.3-15.0%) and 6.9% (95% CI: 4.7-9.8%), respectively, and for sarcopenia, they were 5.3% (95% CI: 3.7-7.7%) and 9.2% (95% CI: 6.4-13.0%), respectively. Incident anemia was associated with incident (RRR = 3.64, 95% CI: 1.18-11.19) but not with persistent (RRR = 0.75, 95% CI: 0.18-3.20) sarcopenia. Persistent anemia was significantly associated with persistent (RRR = 3.59, 95% CI: 1.14-11.27) but not incident (RRR = 1.17, 95% CI: 0.30-4.54) sarcopenia. Conclusion: Changes in anemia are significantly associated with incident and persistent sarcopenia. Primary actions to promote a healthy diet rich in antioxidants, high-quality proteins, and micronutrients, as well as moderate physical activity and maintaining a healthy weight, are crucial for the aging population to delay the deleterious effects of anemia and sarcopenia.

Trajectories of sleep duration and quality and their association with mild cognitive impairment, frailty, and all-cause mortality.

OBJECTIVES: To identify longitudinal trajectories of sleep duration and quality and estimate their association with mild cognitive impairment, frailty, and all-cause mortality. METHODS: We used data from three waves (2009, 2014, 2017) of the WHO Study on Global Aging and Adult Health in Mexico. The sample consisted of 2722 adults aged 50 and over. Sleep duration and quality were assessed by self-report. Sleep trajectories were determined by applying growth mixture models. Mixed-effects logistic (mild cognitive impairment) and ordinal logistic (frailty), and Cox proportional hazards (all-cause mortality) models were fitted. RESULTS: Three classes for sleep duration ("optimal-stable," "long-increasing," and "short-decreasing") and quality ("very good-increasing," "very good-decreasing," and "moderate/poor stable") were identified. Compared to the optimal-stable group, the long-increasing trajectory had greater odds for mild cognitive impairment (odds ratio=1.68, 95% CI: 1.01-2.78) and frailty (odds ratio=1.66, 95% CI: 1.13-2.46), and higher risk for all-cause mortality (hazard ratio=1.91, 95% CI: 1.14-3.19); and the short-decreasing class had a higher probability of frailty (odds ratio=1.83, 95% CI: 1.26-2.64). Regarding the sleep quality, the moderate/poor stable trajectory had higher odds of frailty (odds ratio=1.71, 95% CI: 1.18-2.47) than very good-increasing group. CONCLUSIONS: These results have important implications for clinical practice and public health policies, given that the evaluation and treatment of sleep disorders need more attention in primary care settings. Interventions to detect and treat sleep disorders should be integrated into clinical practice to prevent or delay the appearance of alterations in older adults' physical and cognitive function. Further research on sleep quality and duration is warranted to understand their contribution to healthy aging.

Predictors of Frailty Transitions in Mexican Older Adults.

BACKGROUND: Frailty is a dynamic state in older adults. Current evidence, mostly in high-income countries, found that improving frailty is more likely in mild states (prefrailty). We aimed to determine the probability of frailty transitions and their predictors. METHODS: Participants were adults aged 50 years or over from the Study on Global Ageing and Adult Health in Mexico during 4 waves (2009, 2014, 2017, and 2021). We defined frailty with the frailty phenotype and we used multinomial logistic models to estimate the probabilities of frailty transitions and determine their predictors. RESULTS: For the 3 analyzed periods (2009-2014, 2014-2017, and 2017-2021), transition probabilities from frail to robust were higher for the younger age group (50-59 years) at 0.20, 0.26, and 0.20, and lower for the older age group (≥80 years), 0.03, 0.08 and 0.04. Transitioning from prefrail to robust had probabilities of 0.38, 0.37, and 0.35, for the younger age group, and 0.09, 0.18, and 0.10, for the older age group. The probabilities of transitioning to frail and to death were lower for the younger age group and for the robust at baseline; but higher for the older age group and for the frail at baseline. We identified age, disability, and diabetes as the most significant predictors of frailty transitions. CONCLUSIONS: These findings show that frailty has a dynamic nature and that a significant proportion of prefrail and frail individuals can recover to a robust or prefrail state. They also emphasize that prefrailty should be the focus of interventions.

Telomere Length is Associated with the Prevalence, Persistence, and Incidence of Sarcopenia.

BACKGROUND: Telomere length (TL) shortening has been identified as a marker of aging and associated with adverse health outcomes, but evidence of its association with sarcopenia is inconclusive. AIMS: Estimate the cross-sectional and prospective associations between TL and sarcopenia. METHODS: We used data from Waves 3 and 4 (2017, 2021) of the Study on Global Aging and Adult Health in Mexico (SAGE-Mexico). The cross-sectional sample consisted of 1,738 adults aged 50 and older, and the longitudinal sample consisted of 1,437. Relative TL was determined by real-time quantitative polymerase chain reaction (qPCR) on DNA extracted from saliva samples and quantified as the telomere/single-copy gene (T/S) ratio. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People (EWGSOP2). RESULTS: The mean salivary TL was 1.50 T/S units (95% CI: 1.49-1.52). The baseline prevalence of sarcopenia was 13.3% (95% CI: 9.8-16.8%). The incidence and persistence of sarcopenia were 6.8% (95% CI: 5.0-9.5%) and 7.0% (95% CI: 5.1-9.6%), respectively. The results showed that a one standard deviation decrease in TL was cross-sectionally associated with higher odds of sarcopenia (OR = 1.31; 95% CI: 1.03-1.67) and prospectively with a higher incidence (RRR = 1.55; 95% CI: 1.06-2.25) and persistence (RRR = 1.50; 95% CI: 1.01-2.24) of sarcopenia. CONCLUSIONS: Older adults with shorter TL had higher rates of incident and persistent sarcopenia. Implementation of interventions to delay the decline of TL in older adults is warranted. Further translational studies are needed to elucidate the effects of exercise or diet on DNA repair in the telomeric region and their associations with sarcopenia.

Frailty Was Associated With Atmospheric NO2 Levels: A Geospatial Approach.

BACKGROUND: Recent evidence has linked air pollution with frailty, yet little is known about the role of NO2 in this association. Our aim was to assess the association between frailty and NO2 air concentrations in Mexican older adults. METHODS: We used georeferenced data from the population-based Nutrition and Health Survey in Mexico (NHNS) 2021, representative of national and subnational regions, to measure a frailty index based on 31 health deficits in adults aged 50 and older. Air pollution due to NO2 concentrations was estimated from satellite images validated with data from surface-level stations. Maps were produced using Jensen's Natural break method. The association of frailty and NO2 concentrations was measured using the frailty index (multivariate fractional response logit regression) and a frailty binary variable (frailty index [FI] ≥0.36, multivariate logit regression). RESULTS: There was a positive and significant association of the frailty index with the NO2 concentrations, adjusting for age, sex, urban and rural area, years of education, socioeconomic status, living arrangement, particulate matter smaller than 2.5 microns, and indoor pollution. For each standard deviation increase in NO2 concentrations measured 10 years before the survey, the odds of being frail were 15% higher, and the frailty index was 14.5% higher. The fraction of frailty attributable to NO2 exposure ranged from 1.8% to 23.5% according to different scenarios. CONCLUSIONS: Frailty was positively associated with exposure to NO2 concentrations. Mapping frailty and its associated factors like NO2 air concentrations can contribute to the design of targeted pro-healthy aging policies.

Long-term inequalities in health among older Mexican adults: An outcome-wide analysis.

The relationship between socioeconomic level and health outcomes in older people has been widely studied, but less information about health inequalities associated with gender and place of residence exists. Also, there is scarce evidence of longitudinal inequalities, particularly in countries from the global south. This study aimed to describe the longitudinal patterns of health inequalities associated with wealth, gender, and residence area among older Mexican adults. We used data from two longitudinal studies in Mexico: The Study on Global AGEing and Adult Health (SAGE) and the Mexican Health and Aging Study (MHAS). Three domains to characterize health inequities were used: wealth, gender, and rurality. We conducted an outcome-wide analysis with nine health indicators assessing older adults' physical and cognitive function. The Slope Index of Inequality and the Relative Index of Inequality were used as inequality measurements. Our results indicate that the greatest inequalities are observed in relation to wealth and gender. Older adults with lower socioeconomic status demonstrated higher rates of depression, sarcopenia, falls, and limitations in both basic and instrumental activities of daily living compared to their wealthier counterparts, with increasing trends in physical functionality over time. Furthermore, women experienced higher rates of depression, sarcopenia, frailty, and physical limitations compared to men. The only significant difference related to rurality was a lower rate of frailty among rural older adults. Longitudinal trajectories revealed an increase in the gap of inequality for various health indicators, especially in terms of wealth and gender. Health inequalities in old age are one of the greatest challenges facing health systems globally. Actions like universal coverage of health services for older people and the empowerment of individuals and their communities to have control over their lives and circumstances must be guaranteed.

Dietary Patterns and Geriatric Syndromes in older Mexican adults: Analysis of the 2018-19 National Health and Nutrition Survey.

BACKGROUND: The study of dietary patterns in older adults (OA) and their association with geriatric syndromes (GS) is scarce in Latin America. OBJECTIVE: To describe the association of dietary patterns with GS in the Mexican older adult population, using data from the 2018-19 National Health and Nutrition Survey. METHODS: Dietary data were collected from 3,511 adults (≥60 years of age, both sexes) using a semi-quantitative food frequency questionnaire. Dietary patterns were derived by principal component analysis based on the consumption of 162 foods from 24 food groups. The GS studied were: frailty, depressive symptoms (DS), low appendicular skeletal muscle mass (ASMM); additionally, we studied inflammation (serum CRP>5 mg/L). Logistic regression models were used. RESULTS: Four major dietary patterns were identified: a) "Western", b) "Prudent", c) "Soups", and d) "Traditional". The middle and higher tertiles of the "Prudent" pattern were associated with lower odds of DS (OR 0.71, p = 0.04; and OR 0.61, p = 0.008), respectively. The second tertile of the "Soups" pattern was associated with lower odds of low ASMM (OR 0.68, p = 0031) and inflammation (OR 0.58, p = 0.022). The highest tertile of the "Traditional" pattern was associated with low ASMM (OR 1.55, p = 0.008) and lower odds of inflammation (OR 0.69, p = 0.044). No association was found between the "Western" dietary pattern and GS. CONCLUSIONS: Three of four major dietary patterns were associated with GS in older Mexican adults. Further studies are needed to address strategies to improve diet quality in this age group and its association with health and functional outcomes.

Depression, Anxiety, and Stress Scale: Factor validation during the first COVID-19 lockdown in Mexico

Introduction: Globally, mental health problems have affected nearly 1 billion people and approximately 1 in 10 Mexicans. The detection and surveillance of depression, anxiety, and stress in Mexico requires more reliable and valid instruments. Objective: To determine the factor validity and internal consistency of the Depression, Anxiety, and Stress Scale-21 items (DASS-21) in a non-probabilistic national sample of Mexican adults. Method: Cross-sectional study by means of an online survey of 1 613 Mexican adults aged 18 years and older. The Spanish version of the DASS-21 was used, which evaluates the presence of depressive symptoms, anxiety, and stress. Factor validity was determined by comparing different confirmatory factor analysis models: one-dimensional, three factors (correlated and non-correlated), second order, and bifactor. Results: The application of the bifactor model to the DASS 21, supports its validity for identifying the presence of symptoms of depression, anxiety, and stress, as well as an altered general emotional state in a sample of Mexican adults. Conclusions: The DASS-21 is a theoretically robust instrument useful for research and clinical practice.

Introducción: A nivel global los problemas de salud mental han alcanzado a cerca de 1 billón de personas y aproximadamente a uno de cada diez mexicanos. La detección y vigilancia de depresión, ansiedad y estrés en México demandan instrumentos más confiables y válidos. Objetivo: Determinar la validez factorial y consistencia interna de la Escala de Depresión, Ansiedad y Estrés (DASS-21) en una muestra nacional no probabilística de adultos mexicanos. Método: Estudio transversal por medio de una encuesta en línea entre 1 613 adultos me-xicanos de 18 años o más. Se utilizó la versión en español del DASS-21 que evalúa la presencia de síntomas depresivos, ansiedad y estrés. La validez factorial se determinó mediante la comparación de distintos modelos del análisis factorial confirmatorio: unidimensional; tres factores (correlacionados y no), de segundo orden, y bifactor. Resultados: La aplicación del modelo bifactor al DASS-21 sustenta su validez para identificar la presencia de síntomas de depresión, ansiedad y estrés, así como de un estado general emocional alterado en una muestra de adultos mexicanos. Conclusiones: El DASS-21 es un instrumento teóricamente robusto útil para la investigación y la práctica clínica.

Condiciones de salud, síndromes geriátricos y estado nutricional de los adultos mayores en México / Health conditions, geriatric syndromes and nutritional status of older adults in Mexico

Resumen: Objetivo: Generar un diagnóstico actualizado de las condiciones de salud, síndromes geriátricos y estado nutricional de los adultos mayores mexicanos. Material y métodos: Estudio descriptivo con una muestra de 9 047 adultos mayores de 60 años o más con representatividad nacional. Se analizaron indicadores relacionados con las condiciones de salud, síndromes geriátricos y el estado nutricional. Se reportan las principales prevalencias así como pruebas de diferencias de proporciones y medias. Resultados: Los adultos mayores con mayor edad, mujeres y residentes de áreas rurales mostraron las mayores prevalencias de padecimientos crónicos, síndromes geriátricos y mala nutrición. Conclusiones: Los resultados de este estudio ofrecen un panorama actualizado de las condiciones de salud, síndromes geriátricos y estado nutricional de los adultos mayores mexicanos, y muestran las principales necesidades de salud que este grupo etario enfrenta, las cuales a su vez representan un reto para el sistema de salud en México.

Abstract: Objective: To generate an updated diagnosis of the health conditions, geriatric syndromes, and nutritional status of older Mexican adults. Materials and methods: Descriptive study with a sample of 9 047 older adults aged 60 years and over with national representativeness. We analyzed indicators related to health conditions, geriatric syndromes, and nutritional status, obtaining prevalence as well as tests of differences in proportions and means. Results: Oldest older adults, women, and residents of rural areas showed the highest prevalence of chronic conditions, geriatric syndromes, and poor nutrition. Conclusions: The results of this study offer an updated insight of the health conditions, geriatric syndromes, and nutritional status of older Mexican adults, and show the main health needs that this age group faces, which in turn represent a challenge for the health system in Mexico.

Polypharmacy is associated with multiple health-related outcomes in Mexican community-dwelling older adults / La polifarmacia se asocia con múltiples resultados en salud

Abstract: Objective: To determine the association between polypharmacy and multiple health-related outcomes in older adults. Materials and methods: We carried out a cross-sectional analysis with 274 community-dwelling older adults aged ≥60 years in Mexico City. We used the following health-related outcomes: frailty, dementia, functional capacity, falls, disability, and quality of life. The main exposure was polypharmacy (chronic use of six or more drugs). Ordinal logistic regression, binary logistic regression, Poisson regression, and linear regression models were used to estimate the association between polypharmacy and the outcomes analyzed. Results: Polypharmacy was present in 45% of the sample. Polypharmacy was significantly associated with frailty status, and marginally, with dementia. We also observed significant associations for instrumental activities of daily living, falls, disability, and quality of life. Conclusions: Given that polypharmacy has reached levels of a global epidemic, it is necessary to take radical actions to reduce the concomitant problems of the use of multiple drugs.

Resumen: Objetivo: Determinar la asociación entre la polifarmacia y múltiples resultados relacionados con la salud de los adultos mayores. Material y métodos: Se llevó a cabo un análisis transversal con 274 adultos mayores que residen en comunidad, edad ≥60 años, en la Ciudad de México. Se utilizaron los siguientes resultados relacionados con la salud: fragilidad, demencia, capacidad funcional, caídas, discapacidad y calidad de vida. La exposición principal fue la polifarmacia (uso crónico de seis o más fármacos). Se utilizaron modelos de regresión logística ordinal, regresión logística binaria, regresión de Poisson y regresión lineal para estimar la asociación entre la polifarmacia y los resultados analizados. Resultados: La polifarmacia estuvo presente en 45% de la muestra. La polifarmacia se asoció significativamente con el estado de fragilidad y marginalmente con la demencia. También se observaron asociaciones significativas para actividades instrumentales de la vida diaria, caídas, discapacidad y calidad de vida. Conclusiones: Dado que la polifarmacia ha alcanzado niveles de epidemia global, es necesario tomar medidas radicales para reducir los problemas concomitantes del uso de múltiples medicamentos.

Socioeconomic inequalities in health and nutrition among older adults in Mexico / Desigualdades socioeconómicas en salud y nutrición entre adultos mayores en México

Abstract: Objective: To analyze the socioeconomic inequalities in health among the population of older adults in Mexico. Materials and methods: Analysis of two national health surveys in Mexico (Ensanut 2012 and Ensanut 100k) in which inequality gradients are estimated for various health and nutrition outcomes of older adults over 60 years, using the Relative Index of Inequality (RII) and the Slope Index of Inequality (SII). Results: Older adults with lower socioeconomic status had worse levels of cognition, instrumental activities of daily living, depressive symptoms, muscle mass, low weight, and anemia. Conclusions: Substantial socioeconomic inequalities in health were observed in this study. Given the rapid growth of the population of older adults in Mexico, our results indicate that urgent actions are necessary to achieve health equity in this population group, particularly universal access to health, as well as universal coverage of health services.

Resumen: Objetivo: Analizar las desigualdades socioeconómicas en salud entre la población de adultos mayores en México. Material y métodos: Análisis de dos encuestas nacionales de salud en México (Ensanut 2012 y Ensanut 100k) en las que se estiman los gradientes de desigualdad para diversos desenlaces en salud y nutrición de los adultos mayores de 60 años en adelante, usando el Índice Relativo de Desigualdad (RII) y el Índice de la Pendiente de Desigualdad (SII). Resultados: Los adultos mayores con menor nivel socioeconómico tuvieron peores niveles de cognición, actividades instrumentales de la vida diaria, síntomas depresivos, masa muscular y anemia. Conclusiones: Se observaron desigualdades socioeconómicas en salud sustanciales. Dado el rápido crecimiento de la población de adultos mayores en México, nuestros resultados indican que son necesarias acciones urgentes para lograr la equidad en salud en este grupo poblacional, particularmente lograr el acceso universal a la salud, así como la cobertura universal de los servicios de salud.

Social determinants of health and frailty are associated with all-cause mortality in older adults / Los determinantes de la salud y la fragilidad están asociados con la mortalidad por todas las causas en adultos mayores

Abstract: Objective: To examine the longitudinal association between the social determinants of health (SDH) and frailty status with all-cause mortality in older Mexican adults. Materials and methods: Longitudinal study with a sample of adults aged 60 and over of Study on Global AGEing and Adult Health (SAGE) in Mexico. A Cox proportional hazard model was used to estimate the SDH and frailty-related hazard ratios (HR) for mortality over the study period. Results: Overall mortality rate was 16.9%. Higher education, having a higher frequency of inter-personal contacts (HR=0.96;p<0.01) reduced the risk of dying, after adjusting for potential confounders. While, not counting on someone to trust (HR= 1.59;p<0.03) and having a sense a lack of control over important decisions in life increased the mortality risk. Conclusions: Given that frailty and the SDH affect health using independent pathways, public health systems in Mexico could benefit from increasing the capacity of identifying frail and isolated older adults and providing a risk-stratified health care accordingly.

Resumen: Objetivo: Examinar la asociación longitudinal entre los determinantes sociales en salud (DSS) y la fragilidad con la mortalidad por todas las causas en adultos mayores mexicanos. Material y métodos: Estudio longitudinal con una muestra de adultos mayores de 60 años o más del estudio Envejecimiento Global y Salud de los Adultos (SAGE, por sus siglas en inglés) en México. Se utilizó el modelo riesgos proporcionales de Cox para estimar la asociación entre DSS y la fragilidad en la mortalidad. Resultados: La tasa de mortalidad general fue 16.9%. Tener mayor educación y una mayor frecuencia de contactos interpersonales (HR= 0.96,p<0.01) reducen el riesgo de morir, después de ajustar por covariables. Mientras tanto, no contar con alguien en quien confiar (HR= 1.59;p<0.03) y tener una sensación de falta de control sobre las decisiones importantes en la vida aumentan el riesgo de mortalidad. Conclusiones: Dado que la fragilidad y los DSS inciden sobre la salud usando vías independientes, el sistema de salud de México se beneficiaría al incrementar su capacidad para detectar a los adultos mayores frágiles y con aislamiento social, para proveer cuidados a la salud.

Advances in Mexico in the middle of the decade of action for road safety 2011-2020 / Avances en México a la mitad del decenio de acción para la seguridad vial 2011-2020

ABSTRACT OBJECTIVE To analyze the progress towards the accomplishment of the expected goal in the middle of the Decade of Action for Road Safety 2011-2020 in Mexico and its states. METHODS This is a secondary analysis of road traffic deaths in Mexico between 1999 and 2015. We projected the trend for the period 2011-2020 using a time series analysis (autoregressive integrated moving average models). We used the value of the Aikaike Information Criterion to determine the best model for the national level and its 32 states. RESULTS Mexico is progressing, approaching the proposed goal, which translates into 10,856 potentially prevented deaths in the five-year period from 2011 to 2015. This was due to a decrease in the number of deaths of motor vehicle occupants, as the deaths of pedestrians and motorcyclists were higher than expected. At least one third of the states had values below their goal; although the mortality rate remains unacceptably high in five of them. We identified four states with more deaths than those originally projected and other states with an increasing trend; thus, both cases need to strengthen their prevention actions. CONCLUSIONS The analysis can allow us to see the progress of the country in the middle of the Decade of Action, as well as identify the challenges in the prevention of traffic injuries in vulnerable users. It contributes with elements that provide a basis for a need to rethink both the national goal and the goal of the different states.

RESUMEN OBJETIVO Analizar el avance de la meta esperada a mitad del Decenio de Acción para la Seguridad Vial 2011-2020 en México y sus entidades federativas. MÉTODOS Análisis secundario de las muertes por accidentes de tránsito en México para el 1999-2015. Se proyectó la tendencia para el periodo 2011-2020 utilizando análisis de series de tiempo (modelos autorregresivos integrados de medias móviles). Se utilizó el valor del Criterio de Información de Aikaike para determinar el mejor modelo para el nivel nacional y sus 32 entidades federativas. RESULTADOS México va avanzando cercano a la meta propuesta, lo que se ha traducido en 10,856 defunciones potencialmente prevenidas en el quinquenio 2011 a 2015. Esto ha sido a expensas de una disminución en el número de muertes de ocupantes de vehículos de motor; ya que las muertes en peatones y motociclistas han ido por arriba de lo que se esperaba. Al menos una tercera parte de las entidades federativas tuvo el número de defunciones por debajo de su meta; aunque en cinco de ellas la tasa de mortalidad continúa inaceptablemente alta. Se identificaron cuatro entidades con más muertes que las proyectadas originalmente y otras con tendencia al incremento donde se requiere, para ambos casos, fortalecer las acciones de prevención. CONCLUSIONES El análisis realizado permite observar los avances del país a mitad del Decenio de Acción, así como identificar los retos en materia de prevención de lesiones causadas por el tránsito en usuarios vulnerables. Aporta elementos para soportar la necesidad de replantear tanto la meta nacional como la de las distintas entidades federativas.

Biodiversidad y síntomas depresivos en adultos mexicanos: exploración de los efectos benéficos del ambiente / Biodiversity and depressive symptoms in Mexican adults: Exploration of beneficial environmental effects

Introducción. La depresión es una enfermedad muy prevalente entre adultos, y es el segundo trastorno mental más frecuente en los centros urbanos de México. Es posible que la exposición a los ambientes naturales y a sus componentes mejore la salud mental de la población. Objetivo. Evaluar la asociación entre indicadores de biodiversidad y la prevalencia de síntomas depresivos en la población adulta (20 a 65 años de edad) de México. Materiales y métodos. Se analizó la información de la Encuesta Nacional de Salud y Nutrición 2006 (ENSANUT 2006), así como el Compendio de Estadísticas Ambientales del 2008. Además, se elaboró un índice de biodiversidad, teniendo en cuenta la abundancia de especies y las ecorregiones en cada entidad federativa, y un modelo de regresión logística multinivel con interceptos aleatorios, y otro de regresión logística múltiple con agrupación por estados. Resultados. Los factores asociados con los síntomas depresivos fueron: ser mujer, considerarse indígena, tener menor escolaridad, vivir sin pareja, carecer de trabajo remunerado de forma regular, padecer una enfermedad crónica y beber alcohol. Se encontró una asociación inversa entre el índice de biodiversidad y la prevalencia de los síntomas depresivos cuando se definió de manera continua y los resultados de la regresión se agruparon por estados (OR=0,71; IC 95% 0,59-0,87). Conclusión. A pesar de su diseño transversal, el estudio contribuye a aumentar la ´evidencia´ científica en torno a los beneficios potenciales que el contacto con la naturaleza y sus componentes tiene para la salud mental.

Introduction: Depression is a highly prevalent illness among adults, and it is the second most frequently reported mental disorder in urban settings in México. Exposure to natural environments and its components may improve the mental health of the population. Objective: To evaluate the association between biodiversity indicators and the prevalence of depressive symptoms among the adult population (20 to 65 years of age) in México. Materials and methods: Information from the Encuesta Nacional de Salud y Nutrición 2006 (ENSANUT 2006) and the Compendio de Estadísticas Ambientales 2008 was analyzed. A biodiversity index was constructed based on the species richness and ecoregions in each state. A multilevel logistic regression model was built with random intercepts and a multiple logistic regression was generated with clustering by state. Results: The factors associated with depressive symptoms were being female, self-perceived as indigenous, lower education level, not living with a partner, lack of steady paid work, having a chronic illness and drinking alcohol. The biodiversity index was found to be inversely associated with the prevalence of depressive symptoms when defined as a continuous variable, and the results from the regression were grouped by state (OR=0.71; 95% CI = 0.59-0.87). Conclusions: Although the design was cross-sectional, this study adds to the evidence of the potential benefits to mental health from contact with nature and its components.

Short-term effect of physical activity and obesity on disability in a sample of rural elderly in Mexico / Efecto a corto plazo de la actividad física y la obesidad sobre la discapacidad en una muestra de ancianos rurales en México

Objective. To estimate the effects of physical activity (PA) and obesity on the cumulative incidence of disability on the basic activities of daily living in the elderly. Materials and methods. Longitudinal study. We selected 2477 participants aged 65-74 years from the impact evaluation study of a non-contributory pension program in Mexico. Participants were without disability at baseline. Katz index was used to assess disability both at baseline and follow-up. PA, body mass index, and covariates were measured at baseline. Results. After 14-months of follow-up, the cumulative incidence of disability reached 10.1%. High PA was found to reduce disability risk (OR=0.64; 95%CI [0.43-0.95]), and the association between obesity and disability was marginally significant (OR=1.36; 95%CI [0.96-1.95]). Conclusions. There is a need to perform a functional assessment of older adults in primary care to identify patients with functional dependence , and to promote physical activity to maintain muscle mass and thus reduce the incidence of disability.

Objetivo. Estimar el efecto de la actividad física (AF) y la obesidad sobre la incidencia acumulada de discapacidad en actividades básicas de la vida diaria en adultos mayores (AM). Material y métodos. Estudio longitudinal. La muestra procede del estudio de evaluación de impacto del Programa 70 y más; seleccionamos 2477 AM de 65-74 años sin discapacidad en la medición basal. La AF, el índice de masa corporal y otras covariables se midieron en el estudio basal. Resultados. La incidencia acumulada de discapacidad, a 14 meses de seguimiento, fue de 10.1%. Después de ajustar por covariables, la AF alta disminuyó el riesgo de discapacidad (RM=0.64; IC95% 0.43-0.95). La obesidad se asoció marginalmente con el riesgo de discapacidad (RM=1.36; IC95% 0.96-1.95). Conclusión. Se requiere incorporar la valoración funcional de los adultos mayores en los niveles primarios de atención para identificar sujetos con dependencia funcional y fomentar la actividad física para mantener la masa muscular y así disminuir la incidencia de la discapacidad.

Validación de un punto de corte para la versión breve de la Escala de Depresión del Centro de Estudios Epidemiológicos en adultos mayores mexicanos / Validation of a cutoff point for the short version of the Depression Scale of the Center for Epidemiologic Studies in older Mexican adults

Objetivo. Identificar un punto de corte válido para la Escala de Depresión del Centro de Estudios Epidemiológicos (CES-D) de siete reactivos, que permita clasificar a los adultos mayores según presencia/ausencia de síntomas depresivos clínicamente significativos. Material y métodos. Estudio de tamizaje con 229 adultos mayores residentes de los estados de Morelos y Tlaxcala en México, que fueron parte de la muestra de la Encuesta Nacional de Salud y Nutrición, 2012. Se estimó la sensibilidad y especificidad asociada con el punto de corte seleccionado usando los criterios diagnósticos del ICD-10 (International Classification of Diseases, 10th revision) y del DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, fourth edition). Resultados. El punto de corte estimado fue CES-D=5. De acuerdo con el ICD-10, los valores obtenidos de sensibilidad y especificidad fueron de 83.3 y 90.2%, y un valor ROC de 87% y, según el DSM-IV, los valores fueron 85, 83.2, y 84%, respectivamente. Conclusiones. La versión abreviada del CES-D puede ser utilizada como una prueba de tamizaje para identificar casos probables de adultos mayores con síntomas depresivos clínicamente significativos.

Objective. To identify a valid cutoff point associated with Center for Epidemiologic Studies, Depression Scale (CES-D) of seven items, which allows the classification of older adults according to presence/absence of clinically significant depressive symptoms. Materials and methods. Screening study with 229 older adults residing in two states of Mexico (Morelos and Tlaxcala), which were part of the sample from the National Survey of Health and Nutrition, 2012. We estimated the sensitivity and specificity associated with the selected cutoff points using the diagnostic criteria of ICD-10 (International Classification of Diseases, 10th revision) and DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, fourth edition). Results. The cutoff point estimated was CES-D=5. According to the ICD-10 sensitivity and specificity were 83.3 and 90.2%, and ROC was 87%. Using DSM-IV, the values were 85, 83.2, and 84%, respectively. Conclusions. The short version of the CES-D can be used as a screening test to identify probable cases of older adults with clinically significant depressive symptoms.

Efectos del Seguro Popular sobre el gasto en salud en hogares mexicanos a diez años de su implementación / Effect of Seguro Popular on health expenditure in Mexican households ten years after its implementation

Objetivo. Estimar el efecto del Seguro Popular (SP) sobre la probabilidad de los hogares de incurrir en gasto en salud (GS), de presentar gastos excesivos en salud (GES) y sobre el monto gastado. Material y métodos. Análisis transversal utilizando datos de la ENSANUT 2012. El efecto del SP se estimó con métodos de pareamiento por puntaje de propensión (n=12 250). Se estimaron el efecto promedio en los hogares con SP (tratados) y diferencias en la mediana de gasto. Resultados. El SP reduce 3.6% la probabilidad del GS y en 7.1% en hogares con enfermos diabéticos o hipertensos. Para el GES la reducción fue de 36% en el ámbito nacional, y para hogares con enfermos y hospitalizados, de 46.5 y 41.7%, respectivamente. Conclusiones. El SP tiene un efecto positivo, al proteger a los hogares del GS y GES, principalmente en hogares con necesidades de salud. Sin embargo, aún existen retos para el SP que incluyen la mejora del acceso de la población de menores recursos a los servicios.

Objective. To estimate the effect of Seguro Popular Program (SP) on the probability of health spending (HE), the excessive expenditure on health (EEH) and the amount of health spending. Materials and methods. Cross-sectional analysis was carried out using data from the ENSANUT 2012. Propensity score matching was used to estimate the effect of SP (n=12.250). We estimated the average effect on SP homes (treated) and differences in median spending. Results. SP reduces the likelihood of HE in 3.6 and 7.1% in households with patients diagnosed with DM and/or hypertension, respectively. The reduction in EEH was 36% at national level. This reduction was 46.5 and 41.7% among households with hospitalized patients and those reporting a sick member. Conclusions. SP has a positive effect, protecting households from having either HE or EEH among those with greater health needs. However, there are still some challenges for the SP, which include improving access to services for low-income population.

Identificação dos usuários segundo nível de satisfação nos módulos gerontológicos empregando a análise de conglomerados / Identification of users using cluster analysis according to degree of satisfaction with geriatric care services / Identificación de los pacientes según nivel de satisfacción en módulos gerontológicos empleando el análisis de conglomerados

Esta pesquisa teve como objetivos identificar os grupos de usuários segundo o grau de satisfação com a atenção recebida nos Módulos Gerontológicos e determinar os principais fatores associados. Trata-se de estudo transversal realizado com 181 usuários nos 36 módulos do Seguro Social dos Trabalhadores Públicos, no México. O nível de satisfação foi avaliado segundo três aspectos: características gerais da atenção recebida, amabilidade no trato e infraestrutura. Foi realizada uma análise de conglomerados para identificar grupos de usuários segundo o grau de satisfação e um modelo de regressão logística ordinal para identificar os fatores associados. Estiveram satisfeitos com o serviço 53% dos usuários; medianamente satisfeitos, 34,3%; e insatisfeitos, 12,7%. Os principais fatores associados com maior grau de satisfação foram: ser mulher, maior idade e ser chefe/a de família. O sistema de saúde deve dirigir sua atenção para esse grupo populacional que é crescente e incentivar o desenvolvimento de uma atenção de qualidade que contemple as suas necessidades.

The aim of this study was to identify groups of users according to their degree of satisfaction with geriatric care services and determine the primary factors associated with satisfaction. This was a cross-sectional study of 181 people enrolled in 36 modules pertaining to the State Workers Social Security Institute (ISSSTE) in Mexico. Degree of satisfaction was measured according to the following three areas: general characteristics of services offered, friendliness of staff and infrastructure. A cluster analysis was performed to identify groups of users according to their level of satisfaction, and an ordinal logistic regression model was used to determine the associated factors. Fifty-three percent were satisfied with the services, 34.3% were fairly satisfied and 12.7% were dissatisfied. The main characteristics associated with a greater degree of satisfaction were being female, older and the head of household. The health system must address this growing population and ensure the development of quality care to meet their needs.

Se objetivó identificar grupos de usuarios según grado de satisfacción con la atención recibida en Módulos Gerontológicos, y determinar los principales factores asociados. Estudio transversal, muestra de 181 pacientes de los 36 módulos del Seguro Social de Trabajadores Estatales, en México. El nivel de satisfacción fue evaluado bajo tres aspectos: características generales de la atención recibida; amabilidad en el trato e infraestructura. Se realizó análisis de conglomerados para identificar grupos de pacientes según grado de satisfacción y un modelo de regresión logística ordinal para identificar factores asociados. Resultaron satisfechos con el servicio 53% de los pacientes; medianamente satisfechos 34,3% e insatisfechos 12,7%. Los principales factores asociados a mayor grado de satisfacción fueron: ser mujer, mayor edad, ser jefe/a de familia. El sistema de salud debe dirigir su atención a este grupo poblacional creciente, e incentivar el desarrollo de una atención calificada que contemple sus necesidades.

Validación de un punto de corte para la Escala de Depresión del Centro de Estudios Epidemiológicos, versión abreviada (CESD-7) / Validation of a cutoff for the Depression Scale of the Center for Epidemiologic Studies, Brief Version (CESD-7)

OBJETIVO: Evaluar las propiedades psicométricas de la Escala de Depresión del Centro de Estudios Epidemiológicos, versión abreviada (CESD-7) en población adulta mexicana y validar un punto de corte que permita clasificar a los sujetos según la presencia/ausencia de síntomas depresivos clínicamente significativos (SDCS). MATERIAL Y MÉTODOS: Estudio transversal de tamizaje en una submuestra de 301 adultos residentes del estado de Morelos en México, que fueron entrevistados originalmente para la Encuesta Nacional de Salud y Nutrición 2012. La sensibilidad y especificidad del punto de corte seleccionado se estimaron utilizando como referencia los criterios diagnósticos del ICD-10 y del DSM-IV. RESULTADOS: El punto de corte estimado fue CESD-7=9. Utilizando el ICD-10, los valores obtenidos de sensibilidad y especificidad fueron de 90.2 y 86%, y un valor receptor-operador (ROC) de 88%, y para el DSM-IV los valores encontrados fueron de 80.4, 89.6, y 85%, respectivamente. CONCLUSIONES: La versión abreviada del CESD-7 tiene buenas propiedades psicométricas y puede ser utilizada como una prueba de tamizaje para identificar casos probables de sujetos con síntomas depresivos clínicamente significativos.

OBJECTIVE: To evaluate the Depression Scale of the Center for Epidemiologic Studies, Brief Version (CESD-7) psychometric properties in Mexican adult population, and validate a cutoff for classifying subjects according to the presence / absence of clinically significant depressive symptoms (CSDS). MATERIALS AND METHODS: Screening cross-sectional study with a subsample of 301 adult residents of the Morelos state in Mexico, originally interviewed for the National Survey of Health and Nutrition 2012. Sensitivity and specificity of the selected cutoff were estimated using as reference the diagnostic criteria of ICD-10 and DSM-IV. RESULTS: The cutoff point estimated was CESD-7=9. Using the ICD-10 the sensitivity and specificity were 90.2 and 86%, and ROC was 88%. Using DSM-IV, the values were 80.4, 89.6, and 85%, respectively. CONCLUSIONS: The short version of the CESD-7 has good psychometric properties and can be used as a screening test to identify probable cases of subjects with clinically significant depressive symptoms.