Detalhe da pesquisa
1.
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Proc Natl Acad Sci U S A
; 120(25): e2218896120, 2023 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37327313
2.
Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death.
Angew Chem Int Ed Engl
; 63(9): e202314710, 2024 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38230815
3.
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.
Cell Metab
; 36(4): 762-777.e9, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38309267
4.
Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs.
Free Radic Biol Med
; 208: 458-467, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37678654
5.
Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome.
Nat Metab
; 5(12): 2184-2205, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996701
6.
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.
J Clin Invest
; 132(1)2022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34762602
7.
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling.
Transl Res
; 240: 1-16, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34740873
8.
P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.
JCI Insight
; 7(4)2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041620
9.
Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure.
Redox Biol
; 47: 102143, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34592565
10.
Effects of quinones and nitroazoles on free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol.
Chem Phys Lipids
; 222: 8-14, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31005671