1.
Bioorg Med Chem Lett
; 23(14): 4117-9, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23743283
RESUMO
Mitsunobu reactions were employed to link t-butyl esters of α4 integrin inhibitors at each of the termini of a three-arm, 40 kDa, branched PEG. Cleavage of the t-butyl esters using HCO2H provided easily isolated PEG derivatives, which are potent α4 integrin inhibitors, and which achieve sustained levels and bioactivity in vivo, following subcutaneous administration to rats.