Detalhe da pesquisa
1.
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation.
Nat Immunol
; 23(9): 1365-1378, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35999394
2.
Dimers Aren't Forever: CD80 Breaks up with PD-L1.
Immunity
; 51(6): 972-974, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31951541
3.
The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80.
EMBO J
; 42(5): e111556, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36727298
4.
Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
Nature
; 583(7814): 90-95, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32499645
5.
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
Nature
; 584(7819): E2, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32678341
6.
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Proc Natl Acad Sci U S A
; 120(31): e2300895120, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37487077
7.
Regulation of CTLA-4 recycling by LRBA and Rab11.
Immunology
; 164(1): 106-119, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33960403
8.
Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation.
Genes Immun
; 21(6-8): 390-408, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33223527
9.
CTLA-4: a moving target in immunotherapy.
Blood
; 131(1): 58-67, 2018 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29118008
10.
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Blood
; 129(11): 1458-1468, 2017 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28159733
11.
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
J Immunol
; 198(1): 528-537, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27881707
12.
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
J Allergy Clin Immunol
; 142(6): 1932-1946, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29729943
13.
Characterization of CTLA4 Trafficking and Implications for Its Function.
Biophys J
; 115(7): 1330-1343, 2018 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30219287
14.
Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity.
Clin Immunol
; 188: 94-102, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29305966
15.
Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint.
J Autoimmun
; 88: 50-60, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29066221
16.
Confusing signals: recent progress in CTLA-4 biology.
Trends Immunol
; 36(2): 63-70, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25582039
17.
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.
Proc Natl Acad Sci U S A
; 112(2): 524-9, 2015 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25548162
18.
Thymus transplantation for complete DiGeorge syndrome: European experience.
J Allergy Clin Immunol
; 140(6): 1660-1670.e16, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28400115
19.
1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept.
J Immunol
; 195(6): 2657-65, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26276872
20.
A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.
J Immunol
; 194(5): 2148-59, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25632005