Lipid and metabolic profiles in female dogs with mammary carcinoma receiving dietary fish oil supplementation.

BACKGROUND: Dyslipidemias induce angiogenesis and accelerate the development and in vitro growth of breast tumors. The aim of this study was to assess the lipid and metabolic profile of female dogs with mammary carcinomas and their correlations with body condition score and degree of tumor malignancy, as well as to study the effect of dietary fish oil supplementation on these animals. RESULTS: Overweight or obese dogs had more aggressive carcinomas and higher triglyceride (p = 0.0363), VLDL (p = 0.0181), albumin (p = 0.0188), globulin (p = 0.0145) and lactate (p = 0.0255) concentrations. There was no change in the lipid profile after supplementation with fish oil at any concentration. However, in relation to the metabolic profile, glucose (p = 0.0067), total protein (p = 0.0002) and globulin (p = 0.0002) concentrations were increased when 90% omega-3 fish oil was used as a dietary supplement. CONCLUSION: Obese dogs showed altered lipid and metabolic profiles and more aggressive tumors, suggesting an important relationship between dyslipidemia and tumor aggressiveness. Supplementation with fish oil, rich in omega-3 fatty acids, may alter metabolic parameters in cancer patients.

Hyperresistinemia in Obese Female Dogs With Mammary Carcinoma in Benign-Mixed Tumors and Its Correlation With Tumor Aggressiveness and Survival.

Resistin is associated with metabolic, inflammatory, and neoplastic disorders, and is also considered a prognostic marker in human oncology. Canine mammary tumors have epidemiological, clinical, biological, and genetic characteristics similar to those of women and are proposed as a comparative study model. Here, we evaluate the serum levels of resistin in female dogs with or without mammary carcinoma in mixed tumors (CBMT) and its correlation with the proliferative potential of the tumor, obesity, and survival. Eighty dogs grouped according to the presence (50) or absence (30) of CBMT, reproductive status and body condition were assessed for weight, fat percentage, and canine body mass index. The characteristic of the proliferative potential of the tumor (Ki-67) was evaluated. Ki-67 levels (p = 0.024), staging (p = 0.004), and grade (p = 0.016) influenced the survival of the female dogs. Through a multifactorial analysis, it could be seen that the parameters proliferation index (Ki-67) (p = 0.044) and staging (p = 0.036) influenced the survival of the animals. Neutered and overweight dogs from the control and CBMT groups showed hyperresistinemia. Ki-67 expression and resistin levels in dogs with CBMT were higher in overweight dogs than in dogs with normal weight (p = 0.0001). The survival rate of dogs with CBMT, obese and with high levels of resistin (8,400 µg L-1) was lower when compared to those with lower levels of resistin. These results showed an important relationship between hyperresistinemia, tumor proliferative potential and excessive body fat, suggesting that resistin levels may act as an interesting prognostic marker in patients with CBMT.

Desenvolvimento e análise sensorial de bebida probiótica à base de extrato de arroz / Development and sensory analysis of probiotic drink based on rice extract

Alimentos funcionais são a nova tendência da indústria de alimentos, em consequência da comprovação científica das relações existentes entre alimentos e saúde e, sobretudo, do interesse do consumidor por novas alternativas saudáveis. Diante dessa realidade, promoveu-se uma ampla divulgação no uso dos probióticos para a manutenção da saúde do intestino, levando a um considerável aumento no seu consumo. No Brasil, os produtos mais populares, carreadores dessas bactérias, são os leites fermentados. O Kefir apresenta as mesmas características funcionais dos probióticos, mas de custo reduzido. O objetivo deste trabalho foi desenvolver uma bebida à base de extrato de arroz fermentado com kefir não lácteo. A análise sensorial mostrou que a bebida obteve 93,44% de aceitação e 65,57% de intenção de compra pelos provadores. Conclui-se que é viável o desenvolvimento e a comercialização da bebida fermentada funcional a base de extrato de arroz, podendo oferecer benefícios adicionais à saúde dos consumidores.

Propriedades anticarcinogênicas do ácido linoléico conjugado / Anticarcinogenic properties of conjugated linoleic acid

A maioria das substâncias naturais que exibem atividade anticarcinogênica é originada de plantas. Uma exceção é o ácido linoléico conjugado (CLA), um ácido graxo que está presente na gordura do leite. O CLA é um termo que descreve os isômeros geométricos do ácido linoléico com propriedades anticarcinogênicas, reduzindo a incidência de tumores em animais de laboratório e inibição in vitro de células cancerígenas. Atualmente, diversas pesquisas estão relacionando o CLA com redução da glicemia, colesterol sérico, efeitos aterogênicos e gordura corpórea, além da modulação do sistema imune. O objetivo deste estudo foi revisar a literatura a respeito das propriedades anticarcinogênicas do CLA