Detalhe da pesquisa
1.
ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate.
Antimicrob Agents Chemother
; 67(9): e0038123, 2023 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37493373
2.
Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses.
Antimicrob Agents Chemother
; 67(9): e0028423, 2023 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37565762
3.
Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.
Antimicrob Agents Chemother
; 67(11): e0059723, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37791784
4.
A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study.
Antimicrob Agents Chemother
; 66(3): e0221221, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35099272
5.
Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters.
Clin Microbiol Rev
; 33(3)2020 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32238365
6.
Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(9): e0097821, 2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228543
7.
Pharmacokinetics and Target Attainment of SQ109 in Plasma and Human-Like Tuberculosis Lesions in Rabbits.
Antimicrob Agents Chemother
; 65(9): e0002421, 2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228540
8.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32041718
9.
Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum.
Antimicrob Agents Chemother
; 62(2)2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29203492
10.
Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.
bioRxiv
; 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38798577
11.
Adaptation to the intracellular environment of primary human macrophages influences drug susceptibility of Mycobacterium tuberculosis.
Tuberculosis (Edinb)
; 139: 102318, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889104
12.
A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum.
mBio
; 14(2): e0059823, 2023 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017524
13.
CinA mediates multidrug tolerance in Mycobacterium tuberculosis.
Nat Commun
; 13(1): 2203, 2022 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35459278
14.
On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at Mycobacterium tuberculosis.
J Am Soc Mass Spectrom
; 32(11): 2664-2674, 2021 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34672552
15.
Structure, In Vivo Detection, and Antibacterial Activity of Metabolites of SQ109, an Anti-Infective Drug Candidate.
ACS Infect Dis
; 7(8): 2492-2507, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34279904
16.
An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions.
J Vis Exp
; (123)2017 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28518128
17.
Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis.
ACS Infect Dis
; 2(9): 616-626, 2016 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27759369
18.
Prediction of Drug Penetration in Tuberculosis Lesions.
ACS Infect Dis
; 2(8): 552-63, 2016 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27626295