1.
ACS Omega
; 7(24): 20605-20618, 2022 Jun 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35755376
RESUMO
A facile and efficient method has been developed for the synthesis of quinoline-fused fluorescent dihydro/spiro-quinazolinones. A plausible mechanism involving an acid-mediated enaminone intermediate is provided. The reaction proceeded using p-toluene sulfonic acid as a green promoter. The methodology was successful in synthesizing various quinoline-appended spiro-quinazolinones 4a-o. The synthetic utility of compounds 4a-o was demonstrated by synthesizing compounds 6a-d via Suzuki coupling as a key reaction. Significantly, the π-π* electronic transition of compounds 4c and 4k showed a blue shift. The molar extinction coefficient (ε), Stoke's shift (ΔuÌ ), and quantum yield (Φf)c were calculated for these derivatives (4c and 4k).