Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain.

Sullivan, Jennifer A; Stanek, Lisa M; Lukason, Michael J; Bu, Jie; Osmond, Shayla R; Barry, Elizabeth A; O'Riordan, Catherine R; Shihabuddin, Lamya S; Cheng, Seng H; Scaria, Abraham.

Gene Ther ; 25(3): 205-219, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29785047

2.

Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial.

Heier, Jeffrey S; Kherani, Saleema; Desai, Shilpa; Dugel, Pravin; Kaushal, Shalesh; Cheng, Seng H; Delacono, Cheryl; Purvis, Annie; Richards, Susan; Le-Halpere, Annaig; Connelly, John; Wadsworth, Samuel C; Varona, Rafael; Buggage, Ronald; Scaria, Abraham; Campochiaro, Peter A.

Lancet ; 390(10089): 50-61, 2017 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-28526489

3.

CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10.

Ruan, Guo-Xiang; Barry, Elizabeth; Yu, Dan; Lukason, Michael; Cheng, Seng H; Scaria, Abraham.

Mol Ther ; 25(2): 331-341, 2017 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-28109959

4.

Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity.

Zhu, Wan; Shen, Fanxia; Mao, Lei; Zhan, Lei; Kang, Shuai; Sun, Zhengda; Nelson, Jeffrey; Zhang, Rui; Zou, Dingquan; McDougall, Cameron M; Lawton, Michael T; Vu, Thiennu H; Wu, Zhijian; Scaria, Abraham; Colosi, Peter; Forsayeth, John; Su, Hua.

Stroke ; 48(5): 1420-1423, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28325846

5.

Ocular gene therapy for neovascular AMD: a new era? - Authors' reply.

Campochiaro, Peter A; Heier, Jeffrey S; Kherani, Saleema; Le-Halpere, Annaig; Scaria, Abraham.

Lancet ; 390(10108): 2140, 2017 11 11.

Artigo em Inglês | MEDLINE | ID: mdl-29143750

6.

AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model.

Grigsby, Daniel; Klingeborn, Mikael; Kelly, Una; Chew, Lindsey A; Asokan, Aravind; Devlin, Garth; Smith, Sharon; Keyes, Lisa; Timmers, Adrian; Scaria, Abraham; Bowes Rickman, Catherine.

Invest Ophthalmol Vis Sci ; 64(10): 25, 2023 07 03.

Artigo em Inglês | MEDLINE | ID: mdl-37471073

7.

Preclinical studies in support of phase I/II clinical trials to treat GUCY2D-associated Leber congenital amaurosis.

Boye, Sanford L; O'Riordan, Catherine; Morris, James; Lukason, Michael; Compton, David; Baek, Rena; Elmore, Dana M; Peterson, James J; Fajardo, Diego; McCullough, K Tyler; Scaria, Abraham; McVie-Wylie, Alison; Boye, Shannon E.

Mol Ther Methods Clin Dev ; 28: 129-145, 2023 Mar 09.

Artigo em Inglês | MEDLINE | ID: mdl-36654798

8.

Inhibition of choroidal neovascularization in a nonhuman primate model by intravitreal administration of an AAV2 vector expressing a novel anti-VEGF molecule.

Lukason, Michael; DuFresne, Elizabeth; Rubin, Hillard; Pechan, Peter; Li, Qiuhong; Kim, Ivana; Kiss, Szilard; Flaxel, Christina; Collins, Margaret; Miller, Joan; Hauswirth, William; Maclachlan, Timothy; Wadsworth, Samuel; Scaria, Abraham.

Mol Ther ; 19(2): 260-5, 2011 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-20978476

9.

Preclinical safety evaluation of AAV2-sFLT01- a gene therapy for age-related macular degeneration.

Maclachlan, Timothy K; Lukason, Michael; Collins, Margaret; Munger, Robert; Isenberger, Elisabete; Rogers, Cindy; Malatos, Shana; Dufresne, Elizabeth; Morris, James; Calcedo, Roberto; Veres, Gabor; Scaria, Abraham; Andrews, Laura; Wadsworth, Samuel.

Mol Ther ; 19(2): 326-34, 2011 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21119620

10.

Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases.

Schmidt, Moritz J; Gupta, Ashish; Bednarski, Christien; Gehrig-Giannini, Stefanie; Richter, Florian; Pitzler, Christian; Gamalinda, Michael; Galonska, Christina; Takeuchi, Ryo; Wang, Kui; Reiss, Caroline; Dehne, Kerstin; Lukason, Michael J; Noma, Akiko; Park-Windhol, Cindy; Allocca, Mariacarmela; Kantardzhieva, Albena; Sane, Shailendra; Kosakowska, Karolina; Cafferty, Brian; Tebbe, Jan; Spencer, Sarah J; Munzer, Scott; Cheng, Christopher J; Scaria, Abraham; Scharenberg, Andrew M; Cohnen, André; Coco, Wayne M.

Nat Commun ; 12(1): 4219, 2021 07 09.

Artigo em Inglês | MEDLINE | ID: mdl-34244505

11.

Probing the vibrational dynamics of high-lying electronic states using pump-degenerate four-wave mixing.

Liebers, Jörg; Scaria, Abraham; Materny, Arnulf; Kleinekathöfer, Ulrich.

Phys Chem Chem Phys ; 12(6): 1351-6, 2010 Feb 14.

Artigo em Inglês | MEDLINE | ID: mdl-20119613

12.

Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes.

Nass, Shelley A; Mattingly, Maryellen A; Woodcock, Denise A; Burnham, Brenda L; Ardinger, Jeffrey A; Osmond, Shayla E; Frederick, Amy M; Scaria, Abraham; Cheng, Seng H; O'Riordan, Catherine R.

Mol Ther Methods Clin Dev ; 9: 33-46, 2018 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-29349097

13.

Addendum to: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases.

Schmidt, Moritz J; Gupta, Ashish; Bednarski, Christien; Gehrig-Giannini, Stefanie; Richter, Florian; Pitzler, Christian; Gamalinda, Michael; Galonska, Christina; Takeuchi, Ryo; Wang, Kui; Reiss, Caroline; Dehne, Kerstin; Lukason, Michael J; Noma, Akiko; Park-Windhol, Cindy; Allocca, Mariacarmela; Kantardzhieva, Albena; Sane, Shailendra; Kosakowska, Karolina; Cafferty, Brian; Tebbe, Jan; Spencer, Sarah J; Munzer, Scott; Cheng, Christopher J; Scaria, Abraham; Scharenberg, Andrew M; Cohnen, André; Coco, Wayne M.

Nat Commun ; 14(1): 3503, 2023 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-37311765

14.

Development of a cellular model of rod opsin retinitis pigmentosa.

Adamowicz, Matthew; Song, Antonius; Wadsworth, Samuel; Scaria, Abraham; O'Riordan, Catherine.

Adv Exp Med Biol ; 723: 573-9, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22183380

15.

AAVS1-Targeted Plasmid Integration in AAV Producer Cell Lines.

Luo, Yuxia; Frederick, Amy; Martin, John M; Scaria, Abraham; Cheng, Seng H; Armentano, Donna; Wadsworth, Samuel C; Vincent, Karen A.

Hum Gene Ther Methods ; 28(3): 124-138, 2017 06.

Artigo em Inglês | MEDLINE | ID: mdl-28504553

16.

BEST Disease and Gene Therapy.

Scaria, Abraham.

Int Ophthalmol Clin ; 61(4): 167-172, 2021 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-34584054

17.

Adenovirus-mediated expression of p35 prevents hypoxia/reoxygenation injury by reducing reactive oxygen species and caspase activity.

Date, Taro; Belanger, Adam J; Mochizuki, Seibu; Sullivan, Jennifer A; Liu, Louis X; Scaria, Abraham; Cheng, Seng H; Gregory, Richard J; Jiang, Canwen.

Cardiovasc Res ; 55(2): 309-19, 2002 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-12123770

18.

Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors.

Burnham, Brenda; Nass, Shelley; Kong, Elton; Mattingly, MaryEllen; Woodcock, Denise; Song, Antonius; Wadsworth, Samuel; Cheng, Seng H; Scaria, Abraham; O'Riordan, Catherine R.

Hum Gene Ther Methods ; 26(6): 228-42, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26414997

19.

Myocardial expression of baculoviral p35 alleviates doxorubicin-induced cardiomyopathy in rats.

Date, Taro; Luo, Zhengyu; Yamakawa, Midori; Belanger, Adam J; Scaria, Abraham; Cheng, Seng H; Gregory, Richard J; Mochizuki, Seibu; Jiang, Canwen.

Hum Gene Ther ; 14(10): 947-57, 2003 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-12869213

20.

Gene Therapies for Neovascular Age-Related Macular Degeneration.

Pechan, Peter; Wadsworth, Samuel; Scaria, Abraham.

Cold Spring Harb Perspect Med ; 5(7): a017335, 2014 Dec 18.

Artigo em Inglês | MEDLINE | ID: mdl-25524721

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