Detalhe da pesquisa
1.
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.
J Med Chem
; 66(1): 641-656, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36548390
2.
A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity.
Metabolites
; 12(8)2022 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005604
3.
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease.
Sci Transl Med
; 14(630): eabm3682, 2022 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35108063
4.
Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.
Bioorg Med Chem
; 19(19): 5833-51, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903398
5.
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.
Sci Rep
; 11(1): 17977, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34504195
6.
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.
J Med Chem
; 64(16): 12003-12021, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34351166
7.
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
J Med Chem
; 63(15): 8608-8633, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32662649
8.
Experiences in implementing uHTS--cutting edge technology meets the real world.
Curr Drug Discov Technol
; 1(1): 27-35, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16472217
9.
A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development.
J Biomol Screen
; 18(8): 868-78, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23796689
10.
SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease.
ACS Med Chem Lett
; 3(12): 1024-8, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900424
11.
Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease.
ACS Med Chem Lett
; 3(9): 731-5, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900540
12.
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.
J Med Chem
; 55(3): 1021-46, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22224594
13.
A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors.
J Biomol Screen
; 15(5): 478-87, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20395409