1.
J Org Chem
; 78(12): 5955-63, 2013 Jun 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23718859
RESUMO
An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.