Detalhe da pesquisa
1.
Investigating the Cytotoxicity of Ru(II) Polypyridyl Complexes by Changing the Electronic Structure of Salicylaldehyde Ligands.
Inorg Chem
; 63(2): 1083-1101, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38156413
2.
Chemical biology and medicinal chemistry of RNA methyltransferases.
Nucleic Acids Res
; 50(8): 4216-4245, 2022 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35412633
3.
Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres.
Int J Mol Sci
; 25(3)2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38338655
4.
Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria.
Int J Mol Sci
; 25(8)2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38673995
5.
Next Generation of Fluorometric Protease Assays: 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-amides (NBD-Amides) as Class-Spanning Protease Substrates.
Chemistry
; 29(50): e202301855, 2023 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37313627
6.
Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.
Mol Psychiatry
; 27(12): 5070-5085, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36224261
7.
Synthesis of SARS-CoV-2 Mpro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses.
Org Biomol Chem
; 21(18): 3811-3824, 2023 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37078164
8.
Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis.
Bioorg Chem
; 137: 106587, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37163812
9.
A structure-based virtual high-throughput screening, molecular docking, molecular dynamics and MM/PBSA study identified novel putative drug-like dual inhibitors of trypanosomal cruzain and rhodesain cysteine proteases.
Mol Divers
; 2023 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36617352
10.
Selective noncovalent proteasome inhibiting activity of trifluoromethyl-containing gem-quaternary aziridines.
Arch Pharm (Weinheim)
; 356(7): e2300174, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37119396
11.
Inhibitory effects of 190 compounds against SARS-CoV-2 Mpr o protein: Molecular docking interactions.
Arch Pharm (Weinheim)
; 356(8): e2300207, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37255416
12.
Chemical Space Virtual Screening against Hard-to-Drug RNA Methyltransferases DNMT2 and NSUN6.
Int J Mol Sci
; 24(7)2023 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37047081
13.
Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense.
Int J Mol Sci
; 24(10)2023 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37239824
14.
Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors-A Comprehensive Reactivity and Selectivity Study.
Int J Mol Sci
; 24(8)2023 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37108388
15.
Computational Design, Synthesis, and Biophysical Evaluation of ß-Amido Boronic Acids as SARS-CoV-2 Mpro Inhibitors.
Molecules
; 28(5)2023 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36903597
16.
Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 Mpro.
Molecules
; 28(2)2023 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36677572
17.
Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes.
J Biol Chem
; 296: 100565, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33745969
18.
Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain.
Chemistry
; 28(62): e202201636, 2022 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35852812
19.
Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF-CEM and Multidrug-Resistant CEM/ADR5000 Leukemia Cells.
Chem Biodivers
; 19(2): e202100451, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-34871465
20.
Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense.
Int J Mol Sci
; 23(22)2022 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430948