Detalhe da pesquisa
1.
mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.
Mol Cell
; 71(5): 675-688.e6, 2018 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30193095
2.
Polyglutamine disease proteins: Commonalities and differences in interaction profiles and pathological effects.
Proteomics
; : e2300114, 2024 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38615323
3.
The pathobiology of perturbed mutant huntingtin protein-protein interactions in Huntington's disease.
J Neurochem
; 151(4): 507-519, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31418858
4.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Mol Syst Biol
; 14(7): e8071, 2018 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29997244
5.
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Genome Res
; 25(5): 701-13, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25908449
6.
Small-molecule conversion of toxic oligomers to nontoxic ß-sheet-rich amyloid fibrils.
Nat Chem Biol
; 8(1): 93-101, 2011 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22101602
7.
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Genome Med
; 15(1): 50, 2023 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37468900
8.
UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome.
Nucleic Acids Res
; 37(Database issue): D657-60, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18984619
9.
CellFIE: CRISPR- and Cell Fusion-based Two-hybrid Interaction Mapping of Endogenous Proteins.
J Mol Biol
; 433(24): 167305, 2021 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34655654
10.
Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington's Disease Knock-in Mice.
Front Neurosci
; 15: 682172, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34239412
11.
Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content.
J Mol Biol
; 432(7): 2080-2098, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32061932
12.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Cell Rep
; 32(7): 108050, 2020 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32814053
13.
The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice.
Cell Chem Biol
; 26(1): 109-120.e7, 2019 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30472115
14.
A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples.
Methods Mol Biol
; 1780: 31-40, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856013
15.
Current Approaches Toward Quantitative Mapping of the Interactome.
Front Genet
; 7: 74, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27200083
16.
Pathogenic polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis.
PLoS One
; 5(3): e9642, 2010 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20224794