Detalhe da pesquisa
1.
Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface.
Nucleic Acids Res
; 50(6): 3042-3055, 2022 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35234916
2.
Alteration of target cleavage patterns and off-target reduction of antisense oligonucleotides incorporating 2-N-carbamoyl- or (2-pyridyl)guanine.
Org Biomol Chem
; 21(25): 5214-5224, 2023 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37310350
3.
Oligodeoxynucleotides Modified with 2'-O-(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions.
Bioconjug Chem
; 33(2): 272-278, 2022 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35129971
4.
Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H.
Org Biomol Chem
; 20(45): 8917-8924, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36321625
5.
Synthesis of 2'-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2'-modified nucleoside for antisense oligonucleotides.
Bioorg Med Chem
; 73: 117002, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36170759
6.
Synthesis of 2'-O-alkylcarbamoylethyl-modified oligonucleotides with enhanced nuclease resistance that form isostable duplexes with complementary RNA.
Bioorg Med Chem Lett
; 35: 127779, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33434643
7.
Synthesis of Deoxypseudouridine 5'-Triphosphate Bearing the Photoremovable Protecting Group at the N1 Position Capable of Enzymatic Incorporation to DNA.
J Org Chem
; 85(4): 1861-1870, 2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31910013
8.
Synthesis of 2'-O-(N-methylcarbamoylethyl) 5-methyl-2-thiouridine and its application to splice-switching oligonucleotides.
Bioorg Med Chem Lett
; 29(2): 160-163, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30551900
9.
Tolerance of N2-heteroaryl modifications on guanine bases in a DNA G-quadruplex.
Org Biomol Chem
; 17(4): 859-866, 2019 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30627713
10.
DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine.
Org Biomol Chem
; 17(8): 2077-2080, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30681106
11.
Modification of oligonucleotides with weak basic residues via the 2'-O-carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity.
Org Biomol Chem
; 17(19): 4835-4842, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31033986
12.
Deoxynucleoside Triphosphate Containing Pyridazin-3-one Aglycon as a Thymidine Triphosphate Substitute for Primer Extension and Chain Elongation by Klenow Fragments.
J Org Chem
; 83(15): 8353-8363, 2018 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29952565
13.
Synthesis of and triplex formation in oligonucleotides containing 2'-deoxy-6-thioxanthosine.
Bioorg Med Chem
; 26(13): 3785-3790, 2018 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29914771
14.
Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation.
Org Biomol Chem
; 15(5): 1190-1197, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28084483
15.
Synthesis of oligonucleotides containing 2-N-heteroarylguanine residues and their effect on duplex/triplex stability.
Org Biomol Chem
; 15(39): 8371-8383, 2017 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28937703
16.
Synthesis of photocaged 6-O-(2-nitrobenzyl)guanosine and 4-O-(2-nitrobenzyl) uridine triphosphates for photocontrol of the RNA transcription reaction.
Bioorg Med Chem
; 25(21): 6007-6015, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28986114
17.
Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs.
Nucleic Acids Res
; 43(12): 5675-86, 2015 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26013815
18.
Synthesis of 5-[3-(2-aminopyrimidin-4-yl)aminopropyn-1-yl]uracil derivative that recognizes Ade-Thy base pairs in double-stranded DNA.
Bioorg Med Chem Lett
; 26(1): 194-6, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26602276
19.
Photo-controlled binding of MutS to photo-caged DNA duplexes incorporating 4-O-(2-nitrobenzyl) or 4-O-[2-(2-nitrophenyl)propyl]thymidine.
Bioorg Med Chem Lett
; 26(19): 4861-4863, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27567370
20.
Effective Strategy for Conformer-Selective Detection of Short-Lived Excited State Species: Application to the IR Spectroscopy of the N1H Keto Tautomer of Guanine.
J Phys Chem A
; 120(14): 2179-84, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26990184