RESUMO
Maternal adrenal cortical carcinoma in pregnancy is rare. We report a case of an infant born to a mother with a history of adrenal cortical carcinoma. The pregnancy was complicated by fetal exposure to mitotane and dexamethasone. Despite the potential teratogenic exposures, there was no evidence of adrenal dysfunction in the infant. Growth and development at 12 months of age are normal and prognosis appears favorable. The long-term impact of fetal exposure to mitotane and glucocorticoid requires further investigation.
Assuntos
Neoplasias do Córtex Suprarrenal/tratamento farmacológico , Glândulas Suprarrenais/efeitos dos fármacos , Carcinoma Adrenocortical/tratamento farmacológico , Antineoplásicos Hormonais/uso terapêutico , Dexametasona/uso terapêutico , Exposição Materna , Mitotano/uso terapêutico , Complicações Neoplásicas na Gravidez/tratamento farmacológico , Glândulas Suprarrenais/embriologia , Glândulas Suprarrenais/fisiologia , Feminino , Humanos , Lactente , Masculino , Gravidez , Adulto JovemRESUMO
Blastomyces dermatitidis is a dimorphic fungus that can cause granulomatous lesions. Typically, children present with respiratory symptoms. Central nervous system involvement is unusual, and almost always associated with involvement of other organs. This case report, to our knowledge, is the first published case of an adolescent male presenting with panhypopituitarism secondary to a blastomycosis infection.