1.
J Am Chem Soc
; 132(4): 1202-3, 2010 Feb 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20067245
RESUMO
A copper-promoted coupling of vinyl pinacol boronate esters and alcohols for the synthesis of enol ethers is reported. The reaction occurs in 50-99% yield and is compatible with a variety of functional groups. Cupric acetate is the copper source, and triethylamine buffer is used to prevent protodeboration; the reaction occurs at room temperature. In addition to excellent chemoselectivity, the reaction is stereospecific.