Detalhe da pesquisa
1.
Development of a generalized pharmacokinetic model to characterize clinical pharmacokinetics of monomethyl auristatin E-based antibody-drug conjugates.
Br J Clin Pharmacol
; 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38566392
2.
Translational two-pore PBPK model to characterize whole-body disposition of different-size endogenous and exogenous proteins.
J Pharmacokinet Pharmacodyn
; 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38691205
3.
Assessment of AAV9 distribution and transduction in rats after administration through Intrastriatal, Intracisterna magna and Lumbar Intrathecal routes.
Gene Ther
; 30(1-2): 132-141, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35637286
4.
Translational physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies.
J Pharmacokinet Pharmacodyn
; 2023 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558929
5.
Clinical validation of translational antibody PBPK model using tissue distribution data generated with 89Zr-immuno-PET imaging.
J Pharmacokinet Pharmacodyn
; 50(5): 377-394, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37382712
6.
Expansion of platform physiologically-based pharmacokinetic model for monoclonal antibodies towards different preclinical species: cats, sheep, and dogs.
J Pharmacokinet Pharmacodyn
; 2023 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37947924
7.
International society of Pharmacometrics Mentorship Program (IMP): feedback survey from the first cohort of mentor-mentee pairs.
J Pharmacokinet Pharmacodyn
; 50(4): 243-250, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37480411
8.
Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics.
Drug Metab Dispos
; 50(6): 867-878, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35197311
9.
A population physiologically-based pharmacokinetic model to characterize antibody disposition in pediatrics and evaluation of the model using infliximab.
Br J Clin Pharmacol
; 88(1): 290-302, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34189743
10.
Development of a Physiologically-Based Pharmacokinetic Model for Whole-Body Disposition of MMAE Containing Antibody-Drug Conjugate in Mice.
Pharm Res
; 39(1): 1-24, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-35044590
11.
Physiologically-based pharmacokinetic model for pulmonary disposition of protein therapeutics in humans.
J Pharmacokinet Pharmacodyn
; 49(6): 607-624, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36266517
12.
Towards a translational physiologically-based pharmacokinetic (PBPK) model for receptor-mediated transcytosis of anti-transferrin receptor monoclonal antibodies in the central nervous system.
J Pharmacokinet Pharmacodyn
; 49(3): 337-362, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35092540
13.
Physiologically-based pharmacokinetic model for 2,4-dinitrophenol.
J Pharmacokinet Pharmacodyn
; 49(3): 325-336, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35089483
14.
PBPK model for antibody disposition in mouse brain: validation using large-pore microdialysis data.
J Pharmacokinet Pharmacodyn
; 49(6): 579-592, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36088452
15.
Two-pore physiologically based pharmacokinetic model validation using whole-body biodistribution of trastuzumab and different-size fragments in mice.
J Pharmacokinet Pharmacodyn
; 48(5): 743-762, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34146191
16.
Evolution of the Systems Pharmacokinetics-Pharmacodynamics Model for Antibody-Drug Conjugates to Characterize Tumor Heterogeneity and In Vivo Bystander Effect.
J Pharmacol Exp Ther
; 374(1): 184-199, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32273304
17.
Evaluation of Quantitative Relationship Between Target Expression and Antibody-Drug Conjugate Exposure Inside Cancer Cells.
Drug Metab Dispos
; 48(5): 368-377, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32086295
18.
Measurement and Quantitative Characterization of Whole-Body Pharmacokinetics of Exogenously Administered T Cells in Mice.
J Pharmacol Exp Ther
; 368(3): 503-513, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622170
19.
Effect of Size on Solid Tumor Disposition of Protein Therapeutics.
Drug Metab Dispos
; 47(10): 1136-1145, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31387870
20.
Two-pore physiologically based pharmacokinetic model with de novo derived parameters for predicting plasma PK of different size protein therapeutics.
J Pharmacokinet Pharmacodyn
; 46(3): 305-318, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31028591