[Association study between a polymorphism of aldosterone synthetase gene and the pathogenesis of polycystic ovary syndrome].

OBJECTIVE: To investigate the relationship between -344T polymorphism in aldosterone synthetase (CYP11B2) gene promoter region and the pathogenesis of polycystic ovary syndrome (PCOS). METHODS: Ninety two patients with PCOS and controls were genotyped according to the fragment length (273 bp and or 202 bp) of CYP11B2 gene promoter by the technique of polymerase chain reaction-restriction fragment length polymorphism. The levels of luteinizing hormone, follicular stimulating hormone, estrodiol, progesterone, prolactin, testosterone, plasma renin activity (PRA), plasma angiotensin II (PANG II) and aldosterone in the basal state were also determined. Different genotypes between PCOS were compared about their levels of PRA, PANG II, aldosterone and testosterone. RESULTS: (1) The C allele frequencies of CYP11B2 gene in control and PCOS was 22% and 36%, respectively. (2) The frequency of variants (TC, CC) of CYP11B2 gene -344T polymorphism site in PCOS (57%) was significantly higher than that of control subjects (37%). (3) The level of PRA, PANG II, aldosterone, testosterone were all significantly higher in the genotype of -344CC than in that of -344TT in PCOS and normal women (P < 0.01). CONCLUSIONS: (1) The variants (T-->C) of -344T polymorphism site of CYP11B2 gene predisposes increased risk of PCOS. (2) The genotype of -344CC, -344TC may be susceptible genotype of PCOS and has related to the enhanced functional activity of ovarian renin angiotensin system in PCOS.

[Remote fetal monitoring for gestational diabetes mellitus].

OBJECTIVE: To investigate the clinical value of remote fetal monitoring network in the antepartum management of gestational diabetes mellitus (GDM). METHODS: Non-stress test (NST) was preformed in 50 GDM cases by remote electronic fetal monitoring network (test group), and another 50 monitored by daily fetal movement counting and regular NST check-up in hospital served as the control group. Abnormal NST and perinatal outcome were compared between the two groups. RESULTS: The incidence of abnormal NST was significantly higher in the test group than in the control group (34.6% and 25.5%, P<0.05), as with Apgar scores of the neonates between the two groups (9.58+/-0.77 vs 8.70+/-1.23, P<0.01). The incidences of neonatal asphyxia (12.0%) and preterm birth (8.0%) in the test group were lower than those in the control group (24.0% and 22.0%, respectively, P<0.05). There was no significant difference in the rate of cesarean section between the two groups (P>0.05). CONCLUSION: Remote fetal monitoring network can be used to improve perinatal outcome of GDM, and offers a new option of self-monitoring means for pregnant women with GDM.