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Synergy engineering is an important way to enhance the kinetic activity of oxygen-evolution-reaction (OER) electrocatalysts. Here, we fabricated NiFe amorphous nanoreactor (NiFe-ANR) oxide as OER electrocatalysts via a mild self-catalytic reaction. Firstly, the amorphousness helps transform NiFe-ANR into highly active hydroxyhydroxides, and its many fine-grain boundaries increase active sites. More importantly, as proved by experiments and finite element analysis, the nanoreactor structure alters the spatial curvature and the mass transfer over the catalyst, thereby enriching OH- in the catalyst surface and inner part. Thus, the catalyst with the structure of amorphous nanoreactors gained excellent activity, far superior to the NiFe catalyst with the structure of crystalline nanoreactor or amorphous non-nanoreactor. This work provides new insights into the applications and mechanisms of amorphousness and nanoreactors, embodying the "1+1>2" synergy of crystalline state and morphology.
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Heteroatom doping has emerged as a highly effective strategy to enhance the activity of metal-based electrocatalysts toward the oxygen evolution reaction (OER). It is widely accepted that the doping does not switch the OER mechanism from the adsorbate evolution mechanism (AEM) to the lattice-oxygen-mediated mechanism (LOM), and the enhanced activity is attributed to the optimized binding energies toward oxygen intermediates. However, this seems inconsistent with the fact that the overpotential of doped OER electrocatalysts (<300â mV) is considerably smaller than the limit of AEM (>370â mV). To determine the origin of this inconsistency, we select phosphorus (P)-doped nickel-iron mixed oxides as the model electrocatalysts and observe that the doping enhances the covalency of the metal-oxygen bonds to drive the OER pathway transition from the AEM to the LOM, thereby breaking the adsorption linear relation between *OH and *OOH in the AEM. Consequently, the obtained P-doped oxides display a small overpotential of 237â mV at 10â mA cm-2 . Beyond P, the similar pathway transition is also observed on the sulfur doping. These findings offer new insights into the substantially enhanced OER activity originating from heteroatom doping.
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Myocardial T1 reactivity, defined as the relative change in T1 between rest and vasodilator-induced stress, has been proposed as a magnetic resonance imaging (MRI) biomarker of tissue perfusion. We hypothesize that the superparamagnetic iron-oxide nanoparticle, ferumoxytol, sensitizes T1 to changes in the intramyocardial vascular compartment and improves the sensitivity and specificity of T1 reactivity as an imaging biomarker of tissue perfusion. We aim to assess the diagnostic performance of ferumoxytol-enhanced (FE) myocardial T1 reactivity in swine models of myocardial hypoperfusion. We induced acute myocardial hypoperfusion in 13 swine via percutaneous, transcatheter deployment of a 3D printed intracoronary stenosis implant into the left anterior descending coronary artery. We performed native and FE adenosine stress testing using 5(3)3(3)3 MOLLI and SASHA T1 mapping sequences with bSSFP readout on a clinical 3.0 T magnet. MOLLI T1 maps were fitted using both the conventional MOLLI and the Instantaneous Signal Loss (InSiL) T1-fitting algorithms. Regardless of the MOLLI or SASHA pulse sequence or T1-fitting algorithm, ferumoxytol contrast increased the dynamic range of T1 reactivity in both the remote and ischemic myocardial regions. Relative to remote myocardium, native and FE T1 reactivity were blunted in ischemic myocardium (p < 0.05) with InSiL-MOLLI, MOLLI and SASHA. An InSiL-MOLLI-derived FE T1 reactivity threshold of -4.65% had 73.3% sensitivity and 96.2% specificity for prediction of regional wall motion abnormalities (AUC 0.915, 95% CI 0.786-0.979), whereas a SASHA-derived FE T1 reactivity threshold of -5.25% had 75.0% sensitivity and 95.2% specificity (AUC 0.905, 95% CI 0.751-0.979). Ferumoxytol significantly increased the dynamic range of T1 reactivity as a measure of myocardial hypoperfusion in vasodilator stress T1 mapping studies. FE T1 reactivity maps can be used to quantitatively distinguish ischemic and remote myocardium with high specificity in swine models of acute myocardial hypoperfusion.
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Óxido Ferroso-Férrico/química , Imageamento por Ressonância Magnética , Miocárdio/patologia , Animais , Humanos , Masculino , Curva ROC , SuínosRESUMO
PURPOSE: To propose and evaluate a deep learning model for rapid and accurate calculation of myocardial T1 /T2 values based on a previously proposed Bloch equation simulation with slice profile correction (BLESSPC) method. METHODS: Deep learning Bloch equation simulations (DeepBLESS) models are proposed for rapid and accurate T1 estimation for the MOLLI T1 mapping sequence with balanced SSFP readouts and T1 /T2 estimation for a radial simultaneous T1 and T2 mapping (radial T1 -T2 ) sequence. The DeepBLESS models were trained separately based on simulated radial T1 -T2 and MOLLI data, respectively. The DeepBLESS T1 -T2 estimation accuracy was evaluated based on simulated data with different noise levels. The DeepBLESS model was compared with BLESSPC in simulation, phantom, and in vivo studies for the MOLLI sequence at 1.5 T and radial T1 -T2 sequence at 3 T. RESULTS: After DeepBLESS was trained, in phantom studies, DeepBLESS and BLESSPC achieved similar accuracy and precision in T1 -T2 estimations for both MOLLI and radial T1 -T2 (P > .05). For in vivo, DeepBLESS and BLESSPC generated similar myocardial T1 /T2 values for radial T1 -T2 at 3 T (T1 : 1366 ± 31 ms for both methods, P > .05; T2 : 37.4 ms ± 0.9 ms for both methods, P > .05), and similar myocardial T1 values for the MOLLI sequence at 1.5 T (1044 ± 20 ms for both methods, P > .05). DeepBLESS generated a T1 /T2 map in less than 1 second. CONCLUSION: The DeepBLESS model offers an almost instantaneous approach for estimating accurate T1 /T2 values, replacing BLESSPC for both MOLLI and radial T1 -T2 sequences, and is promising for multiparametric mapping in cardiac MRI.
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Aprendizado Profundo , Coração , Coração/diagnóstico por imagem , Imageamento por Ressonância Magnética , Miocárdio , Imagens de Fantasmas , Reprodutibilidade dos TestesRESUMO
BACKGROUND: Cardiovascular disease is the leading cause of death in patients with Duchenne muscular dystrophy (DMD)-a fatal X-linked genetic disorder. Late gadolinium enhancement (LGE) imaging is the current gold standard for detecting myocardial tissue remodeling, but it is often a late finding. Current research aims to investigate cardiovascular magnetic resonance (CMR) biomarkers, including native (pre-contrast) T1 and extracellular volume (ECV) to evaluate the early on-set of microstructural remodeling and to grade disease severity. To date, native T1 measurements in DMD have been reported predominantly at 1.5T. This study uses 3T CMR: (1) to characterize global and regional myocardial pre-contrast T1 differences between healthy controls and LGE + and LGE- boys with DMD; and (2) to report global and regional myocardial post-contrast T1 values and myocardial ECV estimates in boys with DMD, and (3) to identify left ventricular (LV) T1-mapping biomarkers capable of distinguishing between healthy controls and boys with DMD and detecting LGE status in DMD. METHODS: Boys with DMD (N = 28, 13.2 ± 3.1 years) and healthy age-matched boys (N = 20, 13.4 ± 3.1 years) were prospectively enrolled and underwent a 3T CMR exam including standard functional imaging and T1 mapping using a modified Look-Locker inversion recovery (MOLLI) sequence. Pre-contrast T1 mapping was performed on all boys, but contrast was administered only to boys with DMD for post-contrast T1 and ECV mapping. Global and segmental myocardial regions of interest were contoured on mid LV T1 and ECV maps. ROI measurements were compared for pre-contrast myocardial T1 between boys with DMD and healthy controls, and for post-contrast myocardial T1 and ECV between LGE + and LGE- boys with DMD using a Wilcoxon rank-sum test. Results are reported as median and interquartile range (IQR). p-Values < 0.05 were considered significant. Receiver Operating Characteristic analysis was used to evaluate a binomial logistic classifier incorporating T1 mapping and LV function parameters in the tasks of distinguishing between healthy controls and boys with DMD, and detecting LGE status in DMD. The area under the curve is reported. RESULTS: Boys with DMD had significantly increased global native T1 [1332 (60) ms vs. 1289 (56) ms; p = 0.004] and increased within-slice standard deviation (SD) [100 (57) ms vs. 74 (27) ms; p = 0.001] compared to healthy controls. LGE- boys with DMD also demonstrated significantly increased lateral wall native T1 [1322 (68) ms vs. 1277 (58) ms; p = 0.001] compared to healthy controls. LGE + boys with DMD had decreased global myocardial post-contrast T1 [565 (113) ms vs 635 (126) ms; p = 0.04] and increased global myocardial ECV [32 (8) % vs. 28 (4) %; p = 0.02] compared to LGE- boys. In all classification tasks, T1-mapping biomarkers outperformed a conventional biomarker, LV ejection fraction. ECV was the best performing biomarker in the task of predicting LGE status (AUC = 0.95). CONCLUSIONS: Boys with DMD exhibit elevated native T1 compared to healthy, sex- and age-matched controls, even in the absence of LGE. Post-contrast T1 and ECV estimates from 3T CMR are also reported here for pediatric patients with DMD for the first time and can distinguish between LGE + from LGE- boys. In all classification tasks, T1-mapping biomarkers outperform a conventional biomarker, LVEF.
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Cardiomiopatias/diagnóstico por imagem , Imagem Cinética por Ressonância Magnética , Distrofia Muscular de Duchenne/complicações , Miocárdio/patologia , Função Ventricular Esquerda , Remodelação Ventricular , Adolescente , Fatores Etários , California , Cardiomiopatias/etiologia , Cardiomiopatias/patologia , Cardiomiopatias/fisiopatologia , Estudos de Casos e Controles , Criança , Meios de Contraste/administração & dosagem , Humanos , Masculino , Meglumina/administração & dosagem , Meglumina/análogos & derivados , Distrofia Muscular de Duchenne/diagnóstico , Compostos Organometálicos/administração & dosagem , Valor Preditivo dos Testes , Estudos Prospectivos , Índice de Gravidade de Doença , Adulto JovemRESUMO
We propose a simultaneous myocardial T1 and T2 mapping technique using a radial sequence with inversion recovery and T2 preparation, which achieves high accuracy and precision, with T1 and T2 reproducibility similar to the Modified Look-Locker Inversion recovery (MOLLI) sequence and the conventional bright blood T2 mapping technique, respectively. The sequence was developed by incorporating gold angle radial fast low angle shot (FLASH) readout combined with an inversion pulse and T2prep pulses. The extended Bloch equation simulation with slice profile correction (BLESSPC) algorithm was proposed to reconstruct T1 and T2 maps at the same time in a few seconds, while maintaining good T1 and T2 estimation accuracy. Accuracy and precision were compared among the proposed technique, MOLLI and conventional T2 mapping techniques using phantom studies, 10 healthy volunteers and three patients. In phantom studies, the proposed technique was more accurate than MOLLI (P < 0.05) while achieving similar precision (P = 0.3) in T1 estimation, and was more accurate (P < 0.05) and precise (P < 0.001) than conventional T2 mapping (two-parameter fitting) in T2 estimation. In vivo, the proposed technique achieved significantly higher T1 values (P < 0.001) and similar reproducibility (P = 0.3) compared with MOLLI, with significantly lower T2 values (P < 0.001) and similar reproducibility (P = 0.6) compared with the conventional T2 mapping technique. Thus, the proposed radial T1-T2 mapping technique allows for accurate, precise, simultaneous myocardial T1 and T2 mapping in an 11-heartbeat single breath-hold acquisition.
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Coração/diagnóstico por imagem , Imageamento por Ressonância Magnética , Adulto , Idoso , Algoritmos , Simulação por Computador , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Imagens de Fantasmas , Adulto JovemRESUMO
The aim of this work was to develop and evaluate a fast phase contrast magnetic resonance imaging (PC-MRI) technique with hybrid one- and two-sided flow encodings only (HOTFEO) for accurate blood flow and velocity measurements of three-directional velocity encoding PC-MRI. Four-dimensional (4D) PC-MRI acquires flow-compensated (FC) and three-directional flow-encoded (FE) echoes in an interleaved fashion. We hypothesize that the blood flow velocity direction (not magnitude) has minimal change between two consecutive cardiac phases. This assumption provides a velocity direction constraint that can achieve 4/3-fold acceleration using three-directional FE data to calculate FC data instead of acquiring them. The HOTFEO acquisition pattern can address the ill-conditioned constraint and improve the calculation accuracy. HOTFEO was evaluated in healthy volunteers and compared with conventional two-dimensional (2D) and 4D flow imaging techniques with FC and three-directional FE acquisitions (FC/3FE). Compared with FC/3FE, Bland-Altman tests showed that the 4/3-fold accelerated HOTFEO technique resulted in relatively small bias error for total volumetric flow (0.89% for prospective 2D data, -1.19% for retrospective 4D data and -3.40% for prospective 4D data) and maximum peak velocity (0.50% for prospective 2D data, -0.17% for retrospective 4D data and -2.00% for prospective 4D data) measurements in common carotid arteries. HOTFEO can accelerate three-directional velocity encoding PC-MRI whilst maintaining the measurement accuracy of the total volumetric flow and maximum peak velocity.
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Algoritmos , Imageamento por Ressonância Magnética , Reologia , Aceleração , Simulação por Computador , Humanos , Análise Numérica Assistida por Computador , Razão Sinal-RuídoRESUMO
PURPOSE: To develop and evaluate a phase-contrast MRI (PC-MRI) technique with hybrid one and two-sided flow-encoding and velocity spectrum separation (HOTSPA) for accelerated blood flow and velocity measurement. METHODS: In the HOTSPA technique, the two-sided flow encoding (FE) is used for two FE directions and one-sided is used for the remaining FE direction. Such a temporal modulation of the FE strategy allows for separations of the Fourier velocity spectrum into components for the flow-compensated and the three-directional velocity waveforms, accelerating PC-MRI by encoding three-directional velocities using only two repetition times (TRs) instead of four TRs as in standard PC-MRI. The HOTSPA was evaluated and compared with standard PC-MRI in the common carotid arteries of six healthy volunteers. RESULTS: Total volumetric flow and peak velocity measurements based on HOTSPA and the conventional PC-MRI were in good agreement with a bias of -0.005 mL (-0.1% relative bias error) for total volumetric flow and 1.21 cm/s (1.1% relative bias error) for peak velocity, although the total acquisition time was 50% of the conventional PC-MRI. CONCLUSION: The proposed HOTSPA technique achieved nearly two-fold acceleration of PC-MRI while maintaining accuracy for total volumetric flow and peak velocity quantification by separating the paired acquisitions in the Fourier velocity spectrum domain. Magn Reson Med 78:182-192, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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Algoritmos , Velocidade do Fluxo Sanguíneo/fisiologia , Artérias Carótidas/fisiologia , Interpretação de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Angiografia por Ressonância Magnética/métodos , Processamento de Sinais Assistido por Computador , Adulto , Artérias Carótidas/diagnóstico por imagem , Feminino , Humanos , Aumento da Imagem/métodos , Masculino , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
PURPOSE: To develop and validate a technique for myocardial T1 mapping in patients with implantable cardioverter defibrillators (ICDs). METHODS: A MOLLI-based pulse sequence, named Wideband-FLASH-MOLLI, was developed by incorporating a fast low angle shot (FLASH) readout and a wideband inversion pulse. The performance of Wideband-FLASH-MOLLI was evaluated using phantom studies and validated in eight healthy volunteers and ten patients with ICDs at 1.5 Tesla. Comparisons were made between Wideband-FLASH-MOLLI, FLASH-MOLLI, and bSSFP-MOLLI sequences. RESULTS: In phantom studies, the maximum T1 estimation errors using Wideband-FLASH-MOLLI with and without an ICD were less than 3% for T1 range from 212 to 1673 ms. In all healthy volunteers, there was no significant native myocardial T1 estimation difference using Wideband-FLASH-MOLLI before and after the external attachment of an ICD to the body coil (1178 ± 27 ms versus 1174 ± 33 ms; P = 0.41). Due to the presence of an ICD, the magnitude images acquired using bSSFP-MOLLI and FLASH-MOLLI showed severe artifacts within the myocardium. In contrast, no or negligible device-induced artifacts were noted within the myocardial regions of the healthy volunteers or the patients with ICDs when using Wideband-FLASH-MOLLI. CONCLUSION: This study demonstrates the feasibility of using Wideband-FLASH-MOLLI to mitigate image artifacts and to produce accurate myocardial T1 maps in patients with ICDs. Magn Reson Med 77:1495-1504, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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Artefatos , Técnicas de Imagem Cardíaca/métodos , Desfibriladores Implantáveis , Coração/anatomia & histologia , Aumento da Imagem/métodos , Imageamento por Ressonância Magnética/métodos , Processamento de Sinais Assistido por Computador , Adulto , Algoritmos , Feminino , Humanos , Interpretação de Imagem Assistida por Computador/instrumentação , Interpretação de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/instrumentação , Masculino , Pessoa de Meia-Idade , Imagens de Fantasmas , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
PURPOSE: To compare the accuracy and precision of four different T1 estimation algorithms for modified Look-Locker inversion recovery (MOLLI). METHODS: Four T1 estimation algorithms, including the original fit, inversion group (IG) fit, instantaneous signal loss simulation (InSiL), and Bloch equation simulation with slice profile correction (BLESSPC) were studied. T1 estimation accuracy, precision, reproducibility, and sensitivity to heart rate (HR), flip angle (FA), and acquisition scheme (AcS) variations were compared in simulation, phantom, and volunteer studies. RESULTS: T1 estimation accuracy of IG (-2.4% ± 3.9%) and original fit (-3.2% ± 1.4%) were worse than BLESSPC (0.2% ± 1.5%) and InSiL (-0.7% ± 2.1%). The original fit had the best precision for T1 from 409-1884 ms for the same FA (0.67% ± 0.16% versus 0.90% ± 0.23% using IG, 0.78% ± 0.11% using InSiL, 0.77% ± 0.12% using BLESSPC). BLESSPC generated the most consistent in vivo T1 values over different FAs and AcS, and the T1 estimation reproducibility was similar (P > 0.3) among the four methods when FA = 35°. When using FA = 50°, the reproducibility was significantly improved only when using BLESSPC (1.6% ± 0.9 versus 2.6% ± 1.9%, P < 0.05). CONCLUSION: BLESSPC has superior accuracy and is the least sensitive to FA, HR, and AcS variations. T1 estimation using BLESSPC and FA = 50° is superior to conventional MOLLI with FA = 35° in accuracy and precision. Further clinical studies in varying pathological conditions are warranted to confirm our findings. Magn Reson Med 78:1746-1756, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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Algoritmos , Coração/diagnóstico por imagem , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Adulto , Simulação por Computador , Feminino , Humanos , Masculino , Imagens de Fantasmas , Reprodutibilidade dos Testes , Adulto JovemRESUMO
BACKGROUND: To develop an accurate and precise myocardial T1 mapping technique using an inversion recovery spoiled gradient echo readout at 3.0 Tesla (T). THEORY AND METHODS: The modified Look-Locker inversion-recovery (MOLLI) sequence was modified to use fast low angle shot (FLASH) readout, incorporating a BLESSPC (Bloch Equation Simulation with Slice Profile Correction) T1 estimation algorithm, for accurate myocardial T1 mapping. The FLASH-MOLLI with BLESSPC fitting was compared with different approaches and sequences with regards to T1 estimation accuracy, precision and image artifact based on simulation, phantom studies, and in vivo studies of 10 healthy volunteers and three patients at 3.0 Tesla. RESULTS: The FLASH-MOLLI with BLESSPC fitting yields accurate T1 estimation (average error = -5.4 ± 15.1 ms, percentage error = -0.5% ± 1.2%) for T1 from 236-1852 ms and heart rate from 40-100 bpm in phantom studies. The FLASH-MOLLI sequence prevented off-resonance artifacts in all 10 healthy volunteers at 3.0T. In vivo, there was no significant difference between FLASH-MOLLI-derived myocardial T1 values and "ShMOLLI+IE" derived values (1458.9 ± 20.9 ms versus 1464.1 ± 6.8 ms, P = 0.50); However, the average precision by FLASH-MOLLI was significantly better than that generated by "ShMOLLI+IE" (1.84 ± 0.36% variance versus 3.57 ± 0.94%, P < 0.001). CONCLUSION: The FLASH-MOLLI with BLESSPC fitting yields accurate and precise T1 estimation, and eliminates banding artifacts associated with bSSFP at 3.0T.
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Coração/anatomia & histologia , Interpretação de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Adulto , Artefatos , Feminino , Humanos , Masculino , Imagens de Fantasmas , Valores de Referência , Reprodutibilidade dos TestesRESUMO
Cardiovascular side effects of cancer therapeutics are the leading causes of morbidity and mortality in cancer survivors. Anthracyclines (AC) serve as the backbone of many anti-cancer treatment strategies, but dose-dependent myocardial injury limits their use. Cumulative AC exposure can disrupt the dynamic equilibrium of the myocardial microarchitecture while repeated injury and repair leads to myocyte loss, interstitial myocardial fibrosis, and impaired contractility. Although children are assumed to have greater myocardial plasticity, AC exposure at a younger age portends worse prognosis. In older patients, there is lower overall survival once they develop cardiovascular disease. Because aberrations in the myocardial architecture predispose the heart to a decline in function, early detection with sensitive imaging tools is crucial and the implications for resource utilization are substantial. As a comprehensive imaging modality, cardiac magnetic resonance (CMR) imaging is able to go beyond quantification of ejection fraction and myocardial deformation to characterize adaptive microstructural and microvascular changes that are important to myocardial tissue health. Herein, we describe CMR as an established translational imaging tool that can be used clinically to characterize AC-associated myocardial remodeling.
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Antraciclinas/efeitos adversos , Imageamento por Ressonância Magnética/métodos , Infarto do Miocárdio/diagnóstico por imagem , Neoplasias/tratamento farmacológico , Remodelação Ventricular , Adulto , Criança , Humanos , Pessoa de Meia-Idade , Modelos Cardiovasculares , Infarto do Miocárdio/induzido quimicamente , Infarto do Miocárdio/fisiopatologiaRESUMO
PURPOSE: To develop and evaluate a technique for accelerating phase contrast MRI (PC-MRI) acquisitions without significant compromise in flow quantification accuracy. METHODS: PC-MRI is commonly acquired using interleaved flow-compensated (FC) and flow-encoded (FE) echoes. We hypothesized that FC data, which represent background phase, do not change significantly over time. Therefore, we proposed to undersample the FC data and use an FC view sharing (FCVS) approach to synthesize a composite FC frame for each corresponding FE frame. FCVS was evaluated in a flow phantom and healthy volunteers and compared with a standard FC/FE PC-MRI. RESULTS: The FCVS sequence resulted in an error of 0.0% for forward flow and 2.0% for reverse flow volume when compared with FC/FE PC-MRI in a flow phantom. Measurements in the common carotid arteries showed that the FCVS method had -1.16 cm/s bias for maximum peak velocity and -0.019 mL bias in total flow, when compared with FC/FE with the same temporal resolution, but double the total acquisition time. These results represent ≤1.3% bias error in velocity and volumetric flow quantification. CONCLUSION: FCVS can accelerate PC-MRI acquisitions while maintaining flow and velocity measurement accuracy when there is limited temporal variation in the FC data.
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Artefatos , Velocidade do Fluxo Sanguíneo/fisiologia , Artéria Carótida Primitiva/fisiologia , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Angiografia por Ressonância Magnética/métodos , Algoritmos , Artéria Carótida Primitiva/anatomia & histologia , Humanos , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
PURPOSE: To propose a T1 mapping algorithm for the modified Look-Locker inversion-recovery (MOLLI) sequence that can improve T1 estimation accuracy. MATERIALS AND METHODS: The modified T1 mapping algorithm (InSiL) is based on the simulation of MOLLI signal evolution and simulates the longitudinal magnetization signal perturbation by each single-shot image acquisition in MOLLI as an instantaneous signal loss. InSiL was evaluated against original MOLLI using Bloch simulations, phantom studies, and in 15 healthy volunteers at 1.5T. RESULTS: In phantom studies, the maximum absolute error by InSiL is less than 2%, while that by MOLLI is more than 20% for T1 values from 221 msec to 1539 msec. The benefit of InSiL is greatest at heart rate (HR) >80 bpm and T1 >1000 msec, and InSiL reduced MOLLI T1 error from 14.9 ± 4.5% to 0.4 ± 0.3%. Average InSiL-derived native myocardial T1 values at 1.5T in healthy volunteers were significantly higher than MOLLI-derived values by 236.9 ± 11.7 msec (1160.3 ± 25.1 msec vs. 923.4 ± 22.3 msec, P < 0.001) at an average HR of 65.1 ± 14.7 bpm. CONCLUSION: The proposed InSiL approach yields better T1 mapping accuracy than MOLLI, and is less sensitive to HR variation in tissues with longer T1 values.
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Algoritmos , Coração/anatomia & histologia , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Adulto , Feminino , Humanos , Masculino , Imagens de Fantasmas , Reprodutibilidade dos TestesRESUMO
BACKGROUND: To estimate glucose disposal rate (eGDR) as a newly validated surrogate marker of insulin resistance. Few studies have explored the association between changes in eGDR levels and stroke incidence. This study aims to explore the effect of the level of eGDR control on stroke and events. METHODS: Data were obtained from the China Longitudinal Study on Health and Retirement (CHARLS). The eGDR control level was classified using K-means cluster analysis. Logistic regression analysis was used to explore the association between different eGDR control levels and incident stroke. Restrictive cubic spline regression was used to test the potential nonlinear association between cumulative eGDR and stroke incidence. RESULTS: Of the 4790 participants, 304 (6.3%) had a stroke within 3 years. The odds ratio (OR) was 2.34 (95% confidence interval [CI], 1.42-3.86) for the poorly controlled class 4 and 2.56 (95% CI, 1.53-4.30) for the worst controlled class 5 compared with class 1 with the best controlled eGDR. The OR for well-controlled class 2 was 1.28 (95% CI, 0.79-2.05), and the OR for moderately controlled class 3 was 1.95 (95% CI, 1.14-3.32). In restrictive cubic spline regression analysis, eGDR changes are linearly correlated with stroke occurrence. Weighted quartile and regression analysis identified waist circumference and hypertension as key variables of eGDR for predicting incident stroke. CONCLUSIONS: Poorly controlled eGDR level is associated with an increased risk of stroke in middle-aged and elderly people. Monitoring changes in eGDR may help identify individuals at high risk of stroke early.
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Glicemia , Resistência à Insulina , Acidente Vascular Cerebral , Humanos , Masculino , Pessoa de Meia-Idade , Acidente Vascular Cerebral/epidemiologia , Feminino , Incidência , Idoso , China/epidemiologia , Glicemia/metabolismo , Glicemia/análise , Estudos Longitudinais , Fatores de Risco , Biomarcadores/sangueRESUMO
The high-intactness and ultraclean fabrication of suspended 2D materials has always been a challenge due to their atomically thin nature. Here, we present a universal polymer-free transfer approach for fabricating suspended 2D materials by using volatile micro-molecule cyclododecane as the transfer medium, thus ensuring the ultraclean and intact surface of suspended 2D materials. For the fabricated monolayer suspended graphene, the intactness reaches 99% for size below 10 µm and suspended size reaches 36 µm. Owing to the advantages of ultra-cleanness and large size, the thermal conductivity reaches 4914 W m - 1 K - 1 at 338 K. Moreover, this strategy can also realize efficient batch transfer of suspended graphene and is applicable for fabricating other 2D suspended materials such as MoS2. Our research not only establishes foundation for potential applications and investigations of intrinsic properties of large-area suspended 2D materials, but also accelerates the wide applications of suspended graphene grid in ultrahigh-resolution TEM characterization.
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Hydrazine-assisted water electrolysis provides new opportunities to enable energy-saving hydrogen production while solving the issue of hydrazine pollution. Here, the synthesis of compressively strained Ni2 P as a bifunctional electrocatalyst for boosting both the anodic hydrazine oxidation reaction (HzOR) and cathodic hydrogen evolution reaction (HER) is reported. Different from a multistep synthetic method that induces lattice strain by creating core-shell structures, a facile strategy is developed to tune the strain of Ni2 P via dual-cation co-doping. The obtained Ni2 P with a compressive strain of -3.62% exhibits significantly enhanced activity for both the HzOR and HER than counterparts with tensile strain and without strain. Consequently, the optimized Ni2 P delivers current densities of 10 and 100 mA cm-2 at small cell voltages of 0.16 and 0.39 V for hydrazine-assisted water electrolysis, respectively. Density functional theory (DFT) calculations reveal that the compressive strain promotes water dissociation and concurrently tunes the adsorption strength of hydrogen intermediates, thereby facilitating the HER process on Ni2 P. As for the HzOR, the compressive strain reduces the energy barrier of the potential-determining step for the dehydrogenation of *N2 H4 to *N2 H3 . Clearly, this work paves a facile pathway to the synthesis of lattice-strained electrocatalysts via the dual-cation co-doping.
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Single-crystal graphene (SCG) wafers are needed to enable mass-electronics and optoelectronics owing to their excellent properties and compatibility with silicon-based technology. Controlled synthesis of high-quality SCG wafers can be done exploiting single-crystal Cu(111) substrates as epitaxial growth substrates recently. However, current Cu(111) films prepared by magnetron sputtering on single-crystal sapphire wafers still suffer from in-plane twin boundaries, which degrade the SCG chemical vapor deposition. Here, it is shown how to eliminate twin boundaries on Cu and achieve 4 in. Cu(111) wafers with ≈95% crystallinity. The introduction of a temperature gradient on Cu films with designed texture during annealing drives abnormal grain growth across the whole Cu wafer. In-plane twin boundaries are eliminated via migration of out-of-plane grain boundaries. SCG wafers grown on the resulting single-crystal Cu(111) substrates exhibit improved crystallinity with >97% aligned graphene domains. As-synthesized SCG wafers exhibit an average carrier mobility up to 7284 cm2 V-1 s-1 at room temperature from 103 devices and a uniform sheet resistance with only 5% deviation in 4 in. region.
RESUMO
Bilayer graphene (BLG) is intriguing for its unique properties and potential applications in electronics, photonics, and mechanics. However, the chemical vapor deposition synthesis of large-area high-quality bilayer graphene on Cu is suffering from a low growth rate and limited bilayer coverage. Herein, we demonstrate the fast synthesis of meter-sized bilayer graphene film on commercial polycrystalline Cu foils by introducing trace CO2 during high-temperature growth. Continuous bilayer graphene with a high ratio of AB-stacking structure can be obtained within 20 min, which exhibits enhanced mechanical strength, uniform transmittance, and low sheet resistance in large area. Moreover, 96 and 100% AB-stacking structures were achieved in bilayer graphene grown on single-crystal Cu(111) foil and ultraflat single-crystal Cu(111)/sapphire substrates, respectively. The AB-stacking bilayer graphene exhibits tunable bandgap and performs well in photodetection. This work provides important insights into the growth mechanism and the mass production of large-area high-quality BLG on Cu.
RESUMO
Extremely fast-charging lithium-ion batteries are highly desirable to shorten the recharging time for electric vehicles, but it is hampered by the poor rate capability of graphite anodes. Here, we present a previously unreported particle size and electrode porosity dual-gradient structure design in the graphite anode for achieving extremely fast-charging lithium ion battery under strict electrode conditions. We develop a polymer binder-free slurry route to construct this previously unreported type particle size-porosity dual-gradient structure in the practical graphite anode showing the extremely fast-charging capability with 60% of recharge in 10 min. On the basis of dual-gradient graphite anode, we demonstrate extremely fast-charging lithium ion battery realizing 60% recharge in 6 min and high volumetric energy density of 701 Wh liter-1 at the high charging rate of 6 C.