Detalhe da pesquisa
1.
Predicting crystal form stability under real-world conditions.
Nature
; 623(7986): 324-328, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37938708
2.
A data-driven and topological mapping approach for the a priori prediction of stable molecular crystalline hydrates.
Proc Natl Acad Sci U S A
; 119(43): e2204414119, 2022 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36252020
3.
Influence of Solvent Selection on the Crystallizability and Polymorphic Selectivity Associated with the Formation of the "Disappeared" Form I Polymorph of Ritonavir.
Mol Pharm
; 2024 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38900600
4.
Pharmaceutical Development Challenges in a Beyond Rule of Five Prodrug: Case Study of ABBV-167, Phosphate Prodrug of Venetoclax.
Mol Pharm
; 20(11): 5811-5826, 2023 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37750872
5.
Overcoming Bioavailability Challenges of Dasabuvir and Enabling a Triple-Combination Direct-Acting Antiviral HCV Regimen through a Salt of Very Weak Acid for Oral Delivery.
Mol Pharm
; 19(7): 2367-2379, 2022 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35481355
6.
Implications of the Conformationally Flexible, Macrocyclic Structure of the First-Generation, Direct-Acting Anti-Viral Paritaprevir on Its Solid Form Complexity and Chameleonic Behavior.
J Am Chem Soc
; 143(42): 17479-17491, 2021 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34637297
7.
Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties.
Pharm Res
; 38(6): 971-990, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34009625
8.
Novel Physics-Based Ensemble Modeling Approach That Utilizes 3D Molecular Conformation and Packing to Access Aqueous Thermodynamic Solubility: A Case Study of Orally Available Bromodomain and Extraterminal Domain Inhibitor Lead Optimization Series.
J Chem Inf Model
; 61(3): 1412-1426, 2021 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33661005
9.
Elevated pretransplant pulmonary vascular resistance index does not predict mortality after isolated orthotopic heart transplantation in children: A retrospective analysis of the UNOS database.
Pediatr Transplant
; 19(6): 623-33, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26179628
10.
Pulmonary vascular resistance index and mortality after paediatric heart transplant.
Cardiol Young
; 25(6): 1141-7, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25245660
11.
Open aortic valve replacement in a patient with Glanzmann's thrombasthenia: a multidisciplinary strategy to minimize perioperative bleeding.
Transfusion
; 54(2): 300-5, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23710629
12.
Immediate postoperative percutaneous stenting of superior vena cava obstruction following heart transplantation in adult patients with pacemaker leads.
J Card Surg
; 29(5): 733-6, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25039539
13.
In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium.
Arterioscler Thromb Vasc Biol
; 32(1): 92-102, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22034515
14.
Free Energy Perturbation Approach for Accurate Crystalline Aqueous Solubility Predictions.
J Med Chem
; 66(23): 15883-15893, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38016916
15.
Efficient Crystal Structure Prediction for Structurally Related Molecules with Accurate and Transferable Tailor-Made Force Fields.
J Chem Theory Comput
; 18(9): 5725-5738, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35930763
16.
Association of Thoracic Aortic Aneurysm Size With Long-term Patient Outcomes: The KP-TAA Study.
JAMA Cardiol
; 7(11): 1160-1169, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36197675
17.
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.
J Clin Invest
; 118(10): 3343-54, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18769630
18.
Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.
Proc Natl Acad Sci U S A
; 105(35): 12991-6, 2008 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18728188
19.
Understanding stress-induced disorder and breakage in organic crystals: beyond crystal structure anisotropy.
Chem Sci
; 12(42): 14270-14280, 2021 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34760213
20.
Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Mol Cancer Ther
; 20(6): 999-1008, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33785651