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Org Biomol Chem
; 22(13): 2544-2548, 2024 Mar 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38414338
RESUMO
The synthesis of D-glycero-D-manno-heptose-1ß,7-bisphosphate (HBP) from D-mannose is described. This synthetic approach is notable for the elongation of the seventh carbon, employing mannurono-2,6-lactone, the substrate-controlled establishment of the C-6 configuration, and the nucleophilic introduction of phosphate at the C-1 position through the utilization of 4,6-O-benzylidene-α-triflate.