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Matrix metalloproteinase-2 inhibition and Zn2+-chelating activities of pyoverdine-type siderophores.
J Biosci Bioeng
; 97(4): 281-3, 2004.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16233629
RESUMO
Pyoverdine-type siderophores from fluorescent Pseudomonas species were purified by Zn2+-chelate chromatography, and their matrix metalloproteinase-2 (MMP-2) inhibition and metal-ion-chelating activities were studied. Structurally different pyoverdines showed different MMP-2 inhibition activities, and the inhibition activity was correlated with Zn2+-chelating activity. The IC50 value of a pyoverdine ((P113A1)-2, MW 1187) for MMP-2 was 0.27 microg/ml (0.23 microM).