Detalhe da pesquisa
1.
APC/PIK3CA mutations and ß-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells.
Br J Cancer
; 130(1): 151-162, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37968472
2.
An ex vivo screening using mouse brain mitochondria identified seco-cycline D as an inhibitor of mitochondrial permeability transition pore.
Biochem Biophys Res Commun
; 691: 149253, 2024 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38043196
3.
Novel tankyrase inhibitors suppress TDP-43 aggregate formation.
Biochem Biophys Res Commun
; 537: 85-92, 2021 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33387887
4.
RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Cancer Sci
; 109(12): 4003-4014, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30238564
5.
Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.
Bioorg Med Chem Lett
; 27(22): 4994-4998, 2017 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29037944
6.
Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Bioorg Med Chem
; 25(16): 4259-4264, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28662963
7.
Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.
Bioorg Med Chem
; 23(13): 3269-77, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25982074
8.
BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.
Cancer Lett
; 584: 216632, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216082
9.
Reduction of H3K9 methylation by G9a inhibitors improves the development of mouse SCNT embryos.
Stem Cell Reports
; 19(6): 906-921, 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38729154
10.
Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.
J Med Chem
; 66(6): 4059-4085, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36882960
11.
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression.
Nat Commun
; 14(1): 23, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36635268
12.
Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer.
J Med Chem
; 63(8): 4183-4204, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32202790
13.
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J Med Chem
; 62(7): 3407-3427, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30883102
14.
Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans.
Brain Res
; 1295: 186-91, 2009 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19666013