1.
Chembiochem
; 16(7): 1115-9, 2015 May 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25826784
RESUMO
Exchange of the native promoter to the arabinose-inducible promoter PBAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the "on-demand" production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel "mevalagmapeptides" and the highly toxic xenorhabdins were identified by this approach.