Detalhe da pesquisa
1.
A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors.
Clin Cancer Res
; 13(9): 2692-8, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17473201
2.
A phase I trial of intermittent high-dose gefitinib and fixed-dose docetaxel in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 59(4): 467-75, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16896930
3.
Pharmacokinetic basis for differences in methotrexate sensitivity of normal proliferative tissues in the mouse.
Cancer Res
; 40(4): 1230-4, 1980 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-7357552
4.
Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.
Cancer Res
; 35(7): 1737-44, 1975 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-1169115
5.
Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.
Cancer Res
; 36(3): 1151-8, 1976 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-943237
6.
The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors.
Cancer Res
; 51(5): 1412-7, 1991 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-1997179
7.
Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors.
Cancer Res
; 53(3): 587-91, 1993 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-8425192
8.
Enhancement of folate analogue transport inward in L1210 cells during methotrexate therapy of leukemic mice: evidence of the nature of the effect, possible host mediation, and pharmacokinetic significance.
Cancer Res
; 47(20): 5334-9, 1987 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-3498533
9.
Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo.
Cancer Res
; 49(15): 4204-9, 1989 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-2743307
10.
Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.
Cancer Res
; 44(11): 5204-11, 1984 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-6488181
11.
Increased accumulation of methotrexate by murine tumor cells in vitro in the presence of probenecid which is mediated by a preferential inhibition of efflux.
Cancer Res
; 41(3): 966-70, 1981 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-7459883
12.
Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.
Cancer Res
; 41(11 Pt 1): 4441-6, 1981 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-6171339
13.
Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action.
Cancer Res
; 50(15): 4639-43, 1990 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-2369741
14.
Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models.
Cancer Res
; 38(2): 345-53, 1978 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-304375
15.
Intracavitary therapy of murine ovarian cancer with cis-diamminedichloroplatinum(II) and 10-ethyl-10-deazaaminopterin incorporating systemic leucovorin protection.
Cancer Res
; 49(11): 2890-3, 1989 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-2785847
16.
Extent of the requirement for folate transport by L1210 cells for growth and leukemogenesis in vivo.
Cancer Res
; 45(10): 4732-4, 1985 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-3875399
17.
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Cancer Res
; 45(4): 1488-95, 1985 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-3978616
18.
Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model.
Cancer Res
; 36(12): 4679-86, 1976 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-1087182
19.
Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.
Cancer Res
; 36(12): 4672-8, 1976 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-1000510
20.
Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.
Cancer Res
; 41(11 Pt 1): 4447-52, 1981 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-7306968