Design and synthesis of photostable triphenylamine based neutral AIE nano luminogens: specific and long-term tracking of mitochondria in cells.

With the increasing dependence on fluorescence bioimaging, luminogens with aggregation-induced emission (AIE) properties have gained significant attention due to their excellent photostabilization, minimal photobleaching, high reliability, and superior biocompatibility. Since mitochondria are crucial subcellular organelles in eukaryotic cells with important biological functions, organelle-specific AIE emitters with distinct functions have been highly sought after, but with limited success using simple synthetic methods. Here, we describe a strategy for synthesizing two triphenylamine (TPA) based acrylonitriles, tethered to different donor groups, TPA and phenothiazine (PTZ), respectively, with superior AIE properties using Suzuki coupling. We conducted a systematic and detailed experimental analysis of the structural characteristics of both AIE luminogens, which exhibited excellent photostability, a large Stokes shift, and bright solid-state emission. A cell viability study carried out with F1 and F2 dyes revealed that both luminogens exhibited excellent biocompatibility. Based on fluorescence experiments, F2 displayed excellent AIE characteristics, permeability, biocompatibility, and photostability compared to rhodamine 123, allowing it to selectively stain and track mitochondria in cancer cells over an extended period of time. The Pearson correlation coefficient of F2 and rhodamine 123 was estimated to have an r-value of 0.99. Our findings are expected to provide insight into the synthesis of an extensive archive of AIE-based acrylonitriles with fascinating properties for mitochondrial staining.

A new-fangled horizon in leather process to sidestep toxic chrome and formaldehyde using hyperbranched polymer.

A novel chrome-free tanning and formaldehyde-free post tanning process with PEG-melamine base hyperbranched polymer by complexing aluminum (Al3+) present in aluminum sulfate for eco-friendly tanning applications. The hyperbranched polymers PEGM-400-C-Al and PEGM-600-C-Al were synthesized and characterized by FT-IR, NMR, UV, and XRD. The molecular weight of polymers was assessed by GPC and subjected to the leather process. The processed crust leathers were analyzed for physical characteristics by tensile strength, tear strength, elongation, and quality assessments by hand evaluation by experts. FE-SEM analyzed collagen fibers and fiber splitting of goat skin, and COD, BOD, and total solid in spent liquor were analyzed and compared. The highlighting feature of hyperbranched polymers is (a) Improved shrinkage temperature (Ts) (85 ± 1 °C), (b) Improved physical-mechanical properties (c) Better BOD, COD, and total solids over the aluminum sulfate tanning process. This study confirmed that hyperbranched polymer is effective for tanning and post-tanning leather, which obviates the need to use toxic chromium and formaldehyde for tanning leathers.