Detalhe da pesquisa
1.
Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function.
Nucleic Acids Res
; 2024 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38842936
2.
Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res
; 51(18): 10011-10025, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37615563
3.
Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations.
J Am Chem Soc
; 144(31): 14258-14268, 2022 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35914774
4.
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
J Biol Chem
; 295(33): 11656-11668, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32571877
5.
Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia.
BMC Biol
; 14(1): 91, 2016 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27756303
6.
Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85.
J Struct Biol
; 191(2): 214-23, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26066970
7.
The cryo-EM structure of the BoNT/Wo-NTNH complex reveals two immunoglobulin-like domains.
FEBS J
; 291(4): 676-689, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37746829
8.
X-ray structure of human aldo-keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis.
RSC Med Chem
; 14(2): 341-355, 2023 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36846371
9.
Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7.
Biomed Pharmacother
; 161: 114492, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36931035
10.
Structure and activity of botulinum neurotoxin X.
bioRxiv
; 2023 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36712025
11.
3,5,7-Substituted Pyrazolo[4,3-d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
J Med Chem
; 65(13): 8881-8896, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35749742
12.
Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion.
Nat Commun
; 12(1): 5277, 2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34489474
13.
Structural insight into DNA recognition by bacterial transcriptional regulators of the SorC/DeoR family.
Acta Crystallogr D Struct Biol
; 77(Pt 11): 1411-1424, 2021 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726169
14.
N-Glycosylation can selectively block or foster different receptor-ligand binding modes.
Sci Rep
; 11(1): 5239, 2021 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33664400
15.
Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants.
Environ Pollut
; 268(Pt B): 115960, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33162212
16.
Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure.
Eur J Med Chem
; 216: 113309, 2021 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33711765
17.
3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
J Med Chem
; 64(15): 10981-10996, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34288692
18.
Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis.
FEBS Lett
; 594(7): 1187-1195, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31845319
19.
3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
J Med Chem
; 62(9): 4606-4623, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30943029
20.
Crystal structure of native α-L-rhamnosidase from Aspergillus terreus.
Acta Crystallogr D Struct Biol
; 74(Pt 11): 1078-1084, 2018 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30387766