Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation.

Bork, Francesca; Greve, Carsten L; Youn, Christine; Chen, Sirui; N C Leal, Vinicius; Wang, Yu; Fischer, Berenice; Nasri, Masoud; Focken, Jule; Scheurer, Jasmin; Engels, Pujan; Dubbelaar, Marissa; Hipp, Katharina; Zalat, Baher; Szolek, Andras; Wu, Meng-Jen; Schittek, Birgit; Bugl, Stefanie; Kufer, Thomas A; Löffler, Markus W; Chamaillard, Mathias; Skokowa, Julia; Kramer, Daniela; Archer, Nathan K; Weber, Alexander N R.

EMBO Rep ; 2024 May 23.

Artigo em Inglês | MEDLINE | ID: mdl-38783164

2.

CRISPR-Cas9n-mediated ELANE promoter editing for gene therapy of severe congenital neutropenia.

Nasri, Masoud; Ritter, Malte U; Mir, Perihan; Dannenmann, Benjamin; Kaufmann, Masako M; Arreba-Tutusaus, Patricia; Xu, Yun; Borbaran-Bravo, Natalia; Klimiankou, Maksim; Lengerke, Claudia; Zeidler, Cornelia; Cathomen, Toni; Welte, Karl; Skokowa, Julia.

Mol Ther ; 32(6): 1628-1642, 2024 Jun 05.

Artigo em Inglês | MEDLINE | ID: mdl-38556793

3.

HAX1-related congenital neutropenia: Long-term observation in paediatric and adult patients enrolled in the European branch of the Severe Chronic Neutropenia International Registry (SCNIR).

Pogozhykh, Denys; Yilmaz Karapinar, Deniz; Klimiankou, Maksim; Gerschmann, Natali; Ebetsberger-Dachs, Georg; Palmblad, Jan; Carlsson, Göran; Masmas, Tania; Kinsey, Sally; Bartels, Marije; Mellor-Heineke, Sabine; Welte, Karl; Skokowa, Julia; Zeidler, Cornelia.

Br J Haematol ; 202(2): 393-411, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37193639

4.

SRP54 mutations induce congenital neutropenia via dominant-negative effects on XBP1 splicing.

Schürch, Christoph; Schaefer, Thorsten; Müller, Joëlle S; Hanns, Pauline; Arnone, Marlon; Dumlin, Alain; Schärer, Jonas; Sinning, Irmgard; Wild, Klemens; Skokowa, Julia; Welte, Karl; Carapito, Raphael; Bahram, Seiamak; Konantz, Martina; Lengerke, Claudia.

Blood ; 137(10): 1340-1352, 2021 03 11.

Artigo em Inglês | MEDLINE | ID: mdl-33227812

5.

Differential transcriptional control of hematopoiesis in congenital and cyclic neutropenia patients harboring ELANE mutations.

Zeidler, Alexander; Borbaran-Bravo, Natalia; Dannenmann, Benjamin; Ritter, Malte; Nasri, Masoud; Klimiankou, Maksim; Kandabarau, Sergey; Zahabi, Azadeh; König, Josef; Zeidler, Cornelia; Skokowa, Julia; Welte, Karl.

Haematologica ; 2023 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-37855057

6.

Design of novel granulopoietic proteins by topological rescaffolding.

Hernandez Alvarez, Birte; Skokowa, Julia; Coles, Murray; Mir, Perihan; Nasri, Masoud; Maksymenko, Kateryna; Weidmann, Laura; Rogers, Katherine W; Welte, Karl; Lupas, Andrei N; Müller, Patrick; ElGamacy, Mohammad.

PLoS Biol ; 18(12): e3000919, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33351791

7.

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.

Morishima, Tatsuya; Krahl, Ann-Christin; Nasri, Masoud; Xu, Yun; Aghaallaei, Narges; Findik, Betül; Klimiankou, Maksim; Ritter, Malte; Hartmann, Marcus D; Gloeckner, Christian Johannes; Stefanczyk, Sylwia; Lindner, Christian; Oswald, Benedikt; Bernhard, Regine; Hähnel, Karin; Hermanutz-Klein, Ursula; Ebinger, Martin; Handgretinger, Rupert; Casadei, Nicolas; Welte, Karl; Andre, Maya; Müller, Patrick; Bajoghli, Baubak; Skokowa, Julia.

Blood ; 134(14): 1159-1175, 2019 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-31366618

8.

A zebrafish model for HAX1-associated congenital neutropenia.

Doll, Larissa; Aghaallaei, Narges; Dick, Advaita M; Welte, Karl; Skokowa, Julia; Bajoghli, Baubak.

Haematologica ; 106(5): 1311-1320, 2021 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-32327498

9.

Lentiviral gene therapy and vitamin B3 treatment enable granulocytic differentiation of G6PC3-deficient induced pluripotent stem cells.

Hoffmann, Dirk; Kuehle, Johannes; Lenz, Daniela; Philipp, Friederike; Zychlinski, Daniela; Lachmann, Nico; Moritz, Thomas; Steinemann, Doris; Morgan, Michael; Skokowa, Julia; Klein, Christoph; Schambach, Axel.

Gene Ther ; 27(6): 297-306, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32051561

10.

CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.

Nasri, Masoud; Ritter, Malte; Mir, Perihan; Dannenmann, Benjamin; Aghaallaei, Narges; Amend, Diana; Makaryan, Vahagn; Xu, Yun; Fletcher, Breanna; Bernhard, Regine; Steiert, Ingeborg; Hahnel, Karin; Berger, Jürgen; Koch, Iris; Sailer, Brigitte; Hipp, Katharina; Zeidler, Cornelia; Klimiankou, Maksim; Bajoghli, Baubak; Dale, David C; Welte, Karl; Skokowa, Julia.

Haematologica ; 105(3): 598-609, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-31248972

11.

Cooperating, congenital neutropenia-associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs.

Ritter, Malte; Klimiankou, Maksim; Klimenkova, Olga; Schambach, Axel; Hoffmann, Dirk; Schmidt, Amy; Kanz, Lothar; Link, Daniel C; Welte, Karl; Skokowa, Julia.

Ann Hematol ; 99(10): 2329-2338, 2020 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-32821971

12.

NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils.

Pylaeva, Ekaterina; Harati, Mozhgan Dehghan; Spyra, Ilona; Bordbari, Sharareh; Strachan, Sarah; Thakur, Basant Kumar; Höing, Benedikt; Franklin, Cindy; Skokowa, Julia; Welte, Karl; Schadendorf, Dirk; Bankfalvi, Agnes; Brandau, Sven; Lang, Stephan; Jablonska, Jadwiga.

Int J Cancer ; 144(1): 136-149, 2019 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-30121947

13.

Circumventing Mutation to Nix Neutropenia.

Skokowa, Julia.

N Engl J Med ; 384(20): 1956-1958, 2021 May 20.

Artigo em Inglês | MEDLINE | ID: mdl-34010536

14.

CLPB in neutropenia: 1 gene with many faces.

Lengerke, Claudia; Skokowa, Julia.

Blood ; 139(5): 649-650, 2022 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-35113147

15.

Old drug revisited: disulfiram, NETs, and sepsis.

Klimiankou, Maksim; Skokowa, Julia.

Blood ; 138(25): 2604-2605, 2021 12 23.

Artigo em Inglês | MEDLINE | ID: mdl-34940816

16.

Neutrophils: Between host defence, immune modulation, and tissue injury.

Kruger, Philipp; Saffarzadeh, Mona; Weber, Alexander N R; Rieber, Nikolaus; Radsak, Markus; von Bernuth, Horst; Benarafa, Charaf; Roos, Dirk; Skokowa, Julia; Hartl, Dominik.

PLoS Pathog ; 11(3): e1004651, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25764063

17.

Identification of GFI1 mutations in adult patients with congenital neutropenia.

Boutakoglou, Erasmia; Klimiankou, Maksim; Tsaknakis, Grigorios; Drakos, Elias; Skokowa, Julia; Papadaki, Helen A.

Ann Hematol ; 101(12): 2771-2773, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36112213

18.

GM-CSF treatment is not effective in congenital neutropenia patients due to its inability to activate NAMPT signaling.

Koch, Corinna; Samareh, Bardia; Morishima, Tatsuya; Mir, Perihan; Kanz, Lothar; Zeidler, Cornelia; Skokowa, Julia; Welte, Karl.

Ann Hematol ; 96(3): 345-353, 2017 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-27966038

19.

Chronic neutropenic colitis with complete colonic obstruction in a patient with severe congenital neutropenia associated with G6PC3 mutations.

Nikolouzakis, Taxiarchis Konstantinos; Spyridakis, Konstantinos; Tzardi, Maria; Tsaknakis, Grigorios; Ximeri, Maria; Klimiankou, Maksim; Chrysos, Emmanuel; Skokowa, Julia; Papadaki, Helen A.

Ann Hematol ; 101(7): 1583-1585, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35084551

20.

ELANE mutant-specific activation of different UPR pathways in congenital neutropenia.

Nustede, Rainer; Klimiankou, Maksim; Klimenkova, Olga; Kuznetsova, Inna; Zeidler, Cornelia; Welte, Karl; Skokowa, Julia.

Br J Haematol ; 172(2): 219-27, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26567890

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