Detalhe da pesquisa
1.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
2.
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Bioorg Med Chem Lett
; 28(3): 541-546, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254643
3.
Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ.
J Biol Chem
; 290(13): 8439-46, 2015 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631052
4.
Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.
Biochemistry
; 54(13): 2240-8, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25774576
5.
3-heterocyclyl quinolone inhibitors of the HCV NS5B polymerase.
Bioorg Med Chem Lett
; 22(1): 300-4, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119470
6.
Quinolones as HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 21(1): 82-7, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21145235
7.
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) ß Inhibitor.
J Med Chem
; 61(15): 6858-6868, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30015489
8.
Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.
J Med Chem
; 49(3): 1066-79, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16451072
9.
The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
Structure
; 11(9): 1123-31, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12962630
10.
Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
Structure
; 12(7): 1325-34, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15242608
11.
Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.
J Med Chem
; 59(19): 9228-9242, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27660855
12.
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.
J Med Chem
; 59(7): 3532-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26980109
13.
The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.
J Mol Biol
; 322(3): 559-68, 2002 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12225749
14.
Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J Mol Biol
; 344(2): 527-47, 2004 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15522303
15.
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.
J Med Chem
; 48(24): 7520-34, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16302794
16.
Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV.
J Mol Biol
; 405(5): 1139-53, 2011 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21145896
17.
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
Proc Natl Acad Sci U S A
; 103(31): 11503-8, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16864794
18.
Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles.
Bioorg Med Chem Lett
; 16(15): 4036-40, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16714109
19.
Structure-guided design of peptide-based tryptase inhibitors.
Biochemistry
; 45(19): 5964-73, 2006 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16681368
20.
Peptide ketobenzoxazole inhibitors bound to cathepsin K.
Biochemistry
; 42(51): 15018-28, 2003 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-14690410