Detalhe da pesquisa
1.
A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors.
Proc Natl Acad Sci U S A
; 120(44): e2307793120, 2023 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37878724
2.
Integrated Network Analysis to Determine CNN1, MYL9, TAGLN, and SORBS1 as Potential Key Genes Associated with Prostate Cancer.
Clin Lab
; 69(7)2023 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37436378
3.
A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction.
Proc Natl Acad Sci U S A
; 117(49): 31353-31364, 2020 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33229578
4.
Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.
J Am Chem Soc
; 141(17): 6832-6836, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31017399
5.
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Blood
; 128(7): 971-81, 2016 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27335278
6.
GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex.
Proc Natl Acad Sci U S A
; 111(51): 18261-6, 2014 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25489091
7.
Structural basis of substrate specificity and protease inhibition in Norwalk virus.
J Virol
; 87(8): 4281-92, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365454
8.
Regioselective radical aminofluorination of styrenes.
Angew Chem Int Ed Engl
; 53(41): 11079-83, 2014 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25160663
9.
Targeting SARS-CoV-2 nonstructural protein 3: Function, structure, inhibition, and perspective in drug discovery.
Drug Discov Today
; 29(1): 103832, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37977285
10.
Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease.
ACS Infect Dis
; 10(2): 715-731, 2024 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38192109
11.
Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Bioorg Med Chem Lett
; 23(7): 2158-61, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23428849
12.
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.
Eur J Med Chem
; 260: 115772, 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37659195
13.
Quinazolinone Compounds Have Potent Antiviral Activity against Zika and Dengue Virus.
J Med Chem
; 66(15): 10746-10760, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506506
14.
Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L.
Cancers (Basel)
; 15(21)2023 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37958457
15.
2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-ß-lactamases.
Bioorg Med Chem Lett
; 22(19): 6229-32, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22921080
16.
A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth.
J Hematol Oncol
; 15(1): 41, 2022 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35395864
17.
Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP.
Eur J Med Chem
; 237: 114407, 2022 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35512565
18.
In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus.
Acta Pharm Sin B
; 12(4): 1662-1670, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35847519
19.
Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma.
Transl Oncol
; 18: 101368, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35182954
20.
Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies.
J Am Chem Soc
; 133(42): 16746-9, 2011 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21936531