Detalhe da pesquisa
1.
Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling.
Diabetologia
; 54(5): 1057-65, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21318406
2.
Severe insulin resistance due to anti-insulin antibodies: response to plasma exchange and immunosuppressive therapy.
Diabet Med
; 26(1): 79-82, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19125765
3.
Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance.
J Clin Invest
; 101(5): 1111-20, 1998 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-9486982
4.
Elevated plasma adiponectin in humans with genetically defective insulin receptors.
J Clin Endocrinol Metab
; 91(8): 3219-23, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16705075
5.
Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling.
Circ Res
; 88(9): 895-902, 2001 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11348998
6.
Hybrid insulin receptors. Molecular mechanisms of negative-dominant mutations in receptor-mediated insulin resistance.
Diabetes Care
; 13(6): 576-81, 1990 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-2192845
7.
IRS2 variants and syndromes of severe insulin resistance.
Diabetologia
; 52(6): 1208-11, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19377890
8.
Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject.
Endocrinology
; 144(2): 631-7, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12538626
9.
Hypoglycemia and resistance to ketoacidosis in a subject without functional insulin receptors.
J Clin Endocrinol Metab
; 86(7): 3319-26, 2001 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-11443207
10.
Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities.
J Mol Endocrinol
; 17(3): 237-46, 1996 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-8981230
11.
Multiple molecular mechanisms of insulin receptor dysfunction in a patient with Donohue syndrome.
Diabetes
; 47(8): 1362-4, 1998 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-9703342
12.
Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies.
J Clin Endocrinol Metab
; 95(8): 3641-7, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20484479
13.
Immunological studies of type I IGF receptors and insulin receptors: characterisation of hybrid and atypical receptor subtypes.
Adv Exp Med Biol
; 343: 145-57, 1993.
Artigo
em Inglês
| MEDLINE | ID: mdl-7514333
14.
Functional characterization of a novel insulin receptor mutation contributing to Rabson-Mendenhall syndrome.
Clin Endocrinol (Oxf)
; 66(1): 21-6, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201797
15.
Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors.
Biochem J
; 263(2): 553-63, 1989 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-2480779
16.
Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity.
Biochem J
; 290 ( Pt 2): 419-26, 1993 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-8452530
17.
Inhibitors of phosphoinositide 3-kinase block exocytosis but not endocytosis of transferrin receptors in 3T3-L1 adipocytes.
Biochem Biophys Res Commun
; 211(2): 535-9, 1995 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-7794266
18.
Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules.
EMBO J
; 6(13): 4003-10, 1987 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-2832148
19.
Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants.
J Biol Chem
; 268(2): 1087-94, 1993 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-7678247
20.
Hybrid and atypical insulin/insulin-like growth factor I receptors.
Horm Res
; 41 Suppl 2: 56-64; discussion 65, 1994.
Artigo
em Inglês
| MEDLINE | ID: mdl-8088705